studies

HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 633A
854
Outcomes of Patients Undergoing Liver Transplantation
using Donors with Confirmed Positive Blood Cultures: A
review of the UNOS dataset
Moises Huaman 2 , Valery Vilchez 1 , Xiaonan Mei 1 , Malay B.
Shah 1 , Michael F. Daily 1 , Roberto Gedaly 1 ; 1 Surgery, Univ of Kentucky,
Lexington, KY; 2 Division of Infectious Diseases, Department
of Medicin, University of Kentucky, Lexington, KY
Background: The potential effect of blood culture positive donor
(BCPD) on liver transplant outcomes has not been well established.
We aimed to evaluate the impact of BCPD in patient
and graft survival after liver transplantation. Methods: We
retrieved data from the United Network for Organ Sharing
(UNOS) registry on all adults who underwent primary, single
organ deceased-donor liver transplantation in the US between
2008 and 2013. Patients were classified in two cohorts: the
BCPD cohort and the non-BCPD cohort. Graft and patient survival
at 30 days and 1 year were compared between cohorts.
Multivariable analysis using Cox Proportional Hazard models
for graft survival was performed. Results: A total of 28,961
patients were included in the analysis. There were 2,316
(8.0%) recipients of BCPD. BCPD were more likely to received
organs from female diabetic donors with higher body mass
index compared to non-BCPD. Although patient survival was
similar at 7 days, 1-, 6- and 12 months we found a significant
difference in graft survival at this time lines (p=0.009). On multivariable
analysis, BCPD was independently associated with
decreased graft survival (adjusted OR; 1.10, 95% CI 1.005
– 1.203; P