studies

394A AASLD ABSTRACTS HEPATOLOGY, October, 2015
363
Prediction of Recurrence after Radiofrequency Ablation
of Hepatocellular Carcinoma using Liver Stiffness Measurement
(FibroScan)
Yu Rim Lee 1 , Soo Young Park 1 , Se Young Jang 1 , Su Hyun Lee 1 ,
Sun Kyung Jang 1 , Won Young Tak 1 , Young Oh Kweon 1 , Jung Gil
Park 2 , Seung Up Kim 3 ; 1 Kyunopook National University Hospital,
Daegu, Korea (the Republic of); 2 Internal Medicine, Gastroenterology
and Hepatology, Gumi, Korea (the Republic of); 3 Internal
Medicine, Gastroenterology, Seoul, Korea (the Republic of)
Background. Hepatocellular carcinoma(HCC) is a third leading
cause of cancer related death and incidence is increasing
every year. As active surveillance programs develop, detection
of early stage HCC are increasing. RFA as well as hepatic
resection and liver transplantation have been considered
standard treatments of HCC. However, long-term prognosis
is unsatisfactory due to HCC recurrence associated with liver
fibrosis. The purpose of this study is to predict recurrence after
radiofrequency ablation of hepatocellular carcinoma using
liver stiffness measurement(LSM), which is known related to be
effective in evaluating the liver fibrosis noninvasively. Methods.
A total of 131 patients who performed LSM before RFA
between November, 2008 and December, 2014(training set)
and 55 between November, 2006 and December, 2012(validation
set) was enrolled. Multiple clinical variables including
LSM were analysed for association with recurrence. The result
was applied to validation set. Results. Baseline characteristics
including alfa-fetoprotein, INR, Child-Pugh Class(A/B), underlying
liver disease(B/C/nonB,nonC/Alcohol) and recurrence
rate of training set and validation set were different(p 12.3 kPa had shorter disease free survival
in training set. In validation set, using a cutoff value of LSM
12.3 kPa, recurrence rate were also significantly greater at
LSM values > 12.3 kPa patients(p