studies

1108A AASLD ABSTRACTS HEPATOLOGY, October, 2015
1844
Male gender, genotype 3, previous alcohol use,
increased BMI, and diabetes are factors independently
correlated to advanced HCV chronic liver disease in
Italy: data from PITER (Piattaforma Italiana per lo studio
della Terapia delle Epatiti viRali) cohort study
Loreta A. Kondili 1 , Stefano Rosato 2 , Liliana E. Weimer 1 , Maria
Giovanna Quaranta 1 , Loredana Falzano 1 , Alessandra Mallano
1 , Maria Elena Tosti 2 , Maurizio Massella 1 , Maurizia R. Brunetto
31 , Anna Linda Zignego 4 , Mario Rizzetto 29 , Alfredo Di Leo 24 ,
Giovanni Raimondo 3 , Carlo Ferrari 25 , Antonio Craxi 30 , Gloria
Taliani 5 , Pierluigi Blanc 6 , Antonio Gasbarrini 7 , Luchino Chessa 8 ,
Elke M. Erne 9 , Giovanna Fattovich 10 , Pietro Andreone 11 , Maria
Vinci 12 , Francesco P. Russo 14 , Erica Villa 13 , Giovanni B. Gaeta 15 ,
Teresa A. Santantonio 19 , Guglielmo Borgia 20 , Gabriella Verucchi
21 , Carmine Coppola 22 , Marcello Persico 17 , Liliana Chemello 28 ,
Alfredo Alberti 14 , Vincenzo De Maria 26 , Massimo Puoti 27 , Raffaele
Bruno 18 , Paolo Caraceni 11 , Massimo Andreoni 16 , Marco Marzioni
23 , Stefano Vella 1 ; 1 Therapeutic Research and Medicines Evaluation,
Istituto Superiore di Sanità, Rome, Italy; 2 Istituto Superiore
di Sanità, Rome, Italy; 3 University of Messina, Messina, Italy; 4 University
of Florence, Florence, Italy; 5 Sapienza University of Rome,
Rome, Italy; 6 Santa Maria Annunziata Hospital, Florence, Italy;
7 Policlinico Universitario Agostino Gemelli, Rome, Italy; 8 Azienda
Ospedaliero-Univesitaria di Cagliari, Cagliari, Italy; 9 Azienda
Ospedaliera di Padova, Padova, Italy; 10 Azienda Ospedaliero
Universitaria Integrata di Verona, Verona, Italy; 11 Azienda
Ospedaliero Universitaria di Bologna, Bologna, Italy; 12 Niguarda
Hospital, Milano, Italy; 13 University of Modena, Modena, Italy;
14 Azienda Ospedaliero Universitaria di Padova, Padova, Italy;
15 Second University of Napoli, Napoli, Italy; 16 University Tor Vergata,
Rome, Italy; 17 University of Salerno, Salerno, Italy; 18 University
of Pavia, Pavia, Italy; 19 University of Foggia, Foggia, Italy;
20 Federico II University of Naples, Naples, Italy; 21 Sant’Orsola
Malpighi Hospital, Bologna, Italy; 22 Gragnano Hospital, Napoli,
Italy; 23 Università Politecnica delle Marche, Ancona, Italy; 24 University
of Bari, Bari, Italy; 25 Azienda Ospedaliero-Universitaria di
Parma, Parma, Italy; 26 Azienda Ospedaliero-Universitaria Mater
Domini, Catanzaro, Italy; 27 Azienda Ospedaliera Niguarda-Cà
Granda, Milano, Italy; 28 University of Padua, Padova, Italy; 29 University
of Torino, Torino, Italy; 30 University of Palermo, Palermo,
Italy; 31 Azienda Ospedalero-Universitaria Pisana, Pisa, Italy
Aim: Italy has the highest prevalence rates of HCV infection
in Europe. In order to evaluate factors associated with severe
liver disease in Italian patients in care, data derived from the
PITER cohort study were analysed. Methods: The relationship
between severe fibrosis stage/cirrhosis and sociodemographic
characteristics, HCV RNA genotype, alcohol, body mass index
(BMI), ALT, AST, GGT, platelets, diabetes, cardiovascular,
neurological/psychiatric, autoimmune/reumatological and
neoplastic diseases were evaluated by univariate and logistic
regression statistical models. The regression model’s goodness
of fit (calibration and sensitivity) was also estimated. Results: To
date the cohort consists of 6831 consecutive HCV chronic liver
disease patients (mean age 59±19 years; 3797 males) on clinical
care. HCV genotype 1b (58%) and genotype 2 (15%) are
significantly prevalent in older ages (older than 59 years) compared
to genotypes 3 (10%) and 4 (7%), which are prevalent in
younger ages. F4/cirrhosis stage was present in 2579 (38%)
patients. It increased by age as expected, although 32% of
patients younger than 60 years (3371 patients) had F4/cirrhosis.
Of the enrolled patients, 48% were treatment-experienced.
The independent role of each factor related with F4/cirrhosis,
as defined by the logistic regression analysis, is as follows:
male vs female (3797/3034) OR:1.42 (95% CI:1.25-01.66);
BMI≥25 vs BMI