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How one's lifestyle can affect epigenetic programming Today's science knows that almost every form of lifestyle takes a certain toll on epigenetic programming in the cells. Lifestyle choices include regular exercise, diet, the ambient temperature we are regularly exposed to and even one's mental state, which also influences the epigenetics. In most cases, thousands of genes are activated more heavily or impeded to an extent by such environmental influences, and in most cases, we do not yet know what exactly that means for the cells. Calorie restriction is probably the best understood effect of epigenetic programming. This effect was first observed in 1949 in particularly long-lived and healthy Japanese people (Okinawa). The Okinawa diet is not significantly different from the diet of the rest of the Japanese. The only exception is the number of calories. People from Okinawa ate between 10% and 20% less calories than the rest of the Japanese people. Since then, the lifeprolonging and health-promoting effect of a calorie-reduced diet has been proven in worms, monkeys, rats and humans by means of controlled scientific experiments. Substances that can improve epigenetic programming Today we know that long-term calorie reduction to around 10% below one's basal metabolic rate (but with sufficient micronutrient supply) activates certain genes (DNMT1 and DNMT3b) and implements sanitary epigenetic programming. Thus, bad genes are deactivated while good genes are reactivated. Nowadays, certain food ingredients and drugs that are known to trigger a very similar process in the body have been discovered: Resveratrol from grapes/red wine and the drug metformin. Other foods can enhance epigenetic programming in the cells, thereby restoring the state of younger cells. These include genistein (soy), sulphoraphane (broccoli) and allyl mercaptan (garlic). Resveratrol, genistein, sulphonaphane, allyl mercaptan DEMO_ML Page 116 of 295
EPIGENETICS Your recommendation Based on state of the art science and from an epigenetic point of view, it is recommended that everyone increase their resveratrol intake through increased consumption of grapes, raspberries, mulberries and plums or the moderate consumption of red wine. This will result in a younger epigenetic profile, which can have a positive effect on your health. Furthermore, an increased intake of soy, broccoli, green tea and garlic can help regulate certain positive epigenetic genes. Resverat Genistein Sulforaph. A. Mercapt. Legend: GREEN ARROWS > this nutrient or substance is classed as being healthy for your genetic profile. Try to increase the intake of this substance. RED ARROWS > this substance is classed as being unhealthy for your genetic profile. Try to reduce your intake of the substance. NO ARROWS > The genetics of this section has no effect of the nutrient. PLEASE NOTE! This interpretation only considers your genetic profile of this section. DEMO_ML Page 117 of 295
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Lifestyle genetic analysis Maria Mu
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Lifestyle genetic analysis Personal
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BODY WEIGHT GENES An analysis and l
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physical activity / calorie reducti
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BODY WEIGHT GENES YOUR NUTRITION TY
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ANALYSIS OF TYPE Carbohydrate or fa
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Diet: Balanced diet: carbohydrates
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Your Type: MODERATE CALORY INTAKE T
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ANALYSIS OF STRATEGY Muscles, calor
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SETTING GOALS Your genetic weight l
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NUTRITION Dieting rules Can I cheat
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- - NutriMe Weight Management Your
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WEIGHT ICONS Losing weight with the
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- - Cookbook Menu plans and recipes
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- - The Menu Portal What it contain
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LOSING WEIGHT WITH THE HELP OF THE
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Step 3) How do you follow these gui
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Step 6) How does the food item syst
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LOSING WEIGHT WITH THE HELP OF THE
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Menu plan: Traditional Meal Item We
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Menu plan: Italian Meal Item Weight
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Menu plan: Oriental Meal Item Weigh
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Snacks, that can be eaten any time
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EXERCISE Exercise The goal of aerob
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Example of a training plan with 3 s
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Leisure activities and housework Tr
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EXERCISE Adjustment phase and stabi
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Leisure activities and housework Tr
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Determining your optimal heart rate
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NUTRITION GENES How your genes infl
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Your Result RESULT You have chosen
Page 75 and 76: Nutritional Genes - Milk SYMBOL rs
Page 77 and 78: FOOD INGREDIENTS The effects of ind
Page 79 and 80: NUTRIGENETICS Nutritional Genes - H
Page 81 and 82: NUTRIGENETICS Nutritional Genes - V
Page 83 and 84: Nutritional Genes - Oxidative Stres
Page 85 and 86: NUTRIGENETICS Nutritional Genes - B
Page 87 and 88: NUTRIGENETICS Nutritional Genes - B
Page 89 and 90: NUTRIGENETICS Nutritional Genes - C
Page 91 and 92: NUTRIGENETICS Nutritional Genes - E
Page 93: Summary ß-carotene ß-Carotene ß-
Page 97: Summary Magnesium Magnesium Magnesi
Page 101: Summary Oxalic acid Oxalic a. Oxali
Page 105: Summary Lactose Lactose Lactose Lac
Page 109 and 110: Alcohol Alcohol is a substance that
Page 111 and 112: Sucrose This sugar contains calorie
Page 113 and 114: TABLE How food types are evaluated
Page 115 and 116: and accurate list of ingredients. A
Page 117 and 118: DIETARY SUPPLEMENT This chapter des
Page 119 and 120: This chart shows the shortage of im
Page 122 and 123: BODY WEIGHT GENES YOUR NUTRITION TY
Page 124 and 125: EPIGENETICS Epigenetics - Regulatio
Page 130 and 131: METABOLISM Phase 1 Detoxification f
Page 132 and 133: METABOLISM Oxidative stress and fre
Page 134 and 135: METABOLISM Substances and risks Eve
Page 136 and 137: Nutritional Genes - Oxidative Stres
Page 138 and 139: METABOLISM Prevention PHASE 2 DETOX
Page 142 and 143: Telomeres and biological age BIOLOG
Page 144 and 145: adapted diet as best as possible. Y
Page 146 and 147: BIOLOGICAL AGE Prevention What can
Page 150 and 151: STRESS AND BURNOUT SYNDROME Stress
Page 152 and 153: STRESS Genes relevant to stress Sev
Page 154 and 155: Lack of close, supportive relations
Page 156 and 157: How you should exercise Exercise re
Page 160 and 161: Athletics gene 1 (ACTN3 SNP rs18157
Page 162 and 163: Summary of the genetic predispositi
Page 164 and 165: VO2max Maximal oxygen uptake Cells
Page 166: VO2max Result OXYGEN UPTAKE (VO2max
Page 169 and 170: OXIDATIVE STRESS Athletes produce c
Page 171 and 172: Summary of effects ➤ You have a s
Page 173 and 174: INFLAMMATORY RESPONSE AND INJURY Ce
Page 175 and 176: Summary of effects ➤ The aggressi
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RECOVERY PHASE This chapter gives y
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CALORIES Ideal calorie distribution
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CALORIC DISTRIBUTION Your optimal c
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the order form and no genes are tes
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SCHEDULE The schedule of the perfor
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COMPETITIONS Competition diet The d
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Strategic plan for your athletic ca
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FOOD LIST This individual food list
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Green apple icons Green apple icons
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g per item F Recommendations to los
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SCIENCE The science of genes and ex
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Statement 4 Genes influence how our
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Weight loss program FABP2 - Fatty a
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ADRB2 adrenoceptor beta 2, surface
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APOA5 - Apolipoprotein A-V (rs66279
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Shiwaku K, Nogi A, Anuurad E, Kitaj
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➤ GFHEV-Leitlinien. ➤ Gidh-Jain
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SCIENCE Epigenetics ➤ AAPS J. 201
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Detoxification SCIENCE CYP1A1 - Cyt
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GSTT1 - glutathione S-transferase t
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COMT - Catechol-O-methyltransferase
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PPARG (rs1801282) RES Genotype POP
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Athletic performance Angiotensin co
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Maximal oxygen uptake (VO2max) Nucl
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CRP - C-Reactive Protein (rs3093066
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GSTT1 - glutathione S-transferase t
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SCIENCE Inflammation and risk of in
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IL6R - interleukin 6 receptor (rs22
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- - NutriMe Complete How it works E
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- - Optimized absorption into the b
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- - NutriMe Complete - Proper care
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- - NutriMe Complete - The highest
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- - Effect of your individual micro
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- - Your daily requirement of micro
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- - Follow us on facebook! Follow u
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VERSION HISTORY Science continues t
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➤ V455 - Layout improvements, Des
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CUSTOMER SERVICE Customer Service Q
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NOTES:
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0000000000000 Lifestyle genetic ana
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