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ProVitalDNA - Package - DEMO EN

non-medical analysis - ProVitalDNA

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Athletics gene 1 (ACTN3 SNP rs181573)<br />

COMPETITIVE SPORT<br />

Human muscle fibers can be classified into two categories. Firstly, there are the so-called "slowtwitch"<br />

(red) muscle fibers, which are well supplied with blood, and therefore are optimally<br />

supplied with oxygen. As such, they fatigue slower, which has a positive effect on persistent<br />

activity. These muscle fibers are, however, slow, and do not generate high forces, presenting a<br />

disadvantage for fast and powerful movements. The second type are the "fast-twitch" (white)<br />

muscle fibers, which are less supplied with blood, and therefore get tired more quickly, but<br />

they also react faster and generate higher forces. This property makes these fibers powerful<br />

with fast powerful movements.<br />

The ACTN3 gene is active only in fast-twitch (white) muscle fibers, and plays an important role<br />

in their function. However, this gene is frequently inactive due to a gene mutation, which<br />

reduces the function of white muscle fibers, and thus the power with fast movements.<br />

However, the red muscle fibers increase the stamina of the muscles. Because each individual<br />

has two genes of this type, the following gene combinations are possible:<br />

➤ <strong>EN</strong>DURANCE - Both genes are INACTIVE and produce no ACTN3 protein (24% of population)<br />

➤ POWER - One of the genes is ACTIVE and produces ACTN3 protein (44% of population)<br />

➤ POWER - Both genes are ACTIVE and produce ACTN3 protein (31% of population)<br />

Genetic traits<br />

SYMBOL rs NCBI POLYMORPH G<strong>EN</strong>OTYPE<br />

ACTN3 rs1815739 C>T C/T<br />

Legend: rsNCBI = database number of genetic variation, Polymorphism = type of genetic change, Genotype =<br />

the genetic laboratory result<br />

Your result<br />

The genetic programming of your muscle fibers<br />

<strong>EN</strong>DURANCE<br />

(24% of the population)<br />

POWER<br />

(44% of the population)<br />

POWER<br />

(31% of the population)<br />

▲<br />

One of your two genes is active and hence creates large and strong muscle fibers that are able<br />

to produce strong forces and react quickly. On the downside, they tend to tire more quickly.<br />

The muscle protein Alpha Actinin is being produced, but in somewhat lower amounts.<br />

<strong>DEMO</strong>_ML Page 150 of 295

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