ProVitalDNA - Package - DEMO EN

ADRB2 adrenoceptor beta 2, surface (rs1042714)
The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a beta-adrenergic receptor within a cell membrane
which reacts with adrenaline (epinephrine) as a hormone or neurotransmitter affecting muscles or organs. The ADRB2 gene is
intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal
asthma, excessive weight and type 2 diabetes. This receptor is directly associated with one of its ultimate effectors, the class C L-
type calcium channel CaV1.2. This receptor-channel complex is coupled to the Gs G protein, which activates adenylyl cyclase,
catalysing the formation of cyclic adenosine monophosphate (cAMP) which then activates protein kinase A, and the
counterbalancing phosphatase PP2A.
RES Genotype POP Possible results
C/C 42% Increased maximal oxygen uptake (VO2max)
X C/G 51% Increased maximal oxygen uptake (VO2max)
References
G/G 7% No increased maximal oxygen uptake (VO2max)
Garatachea N et al. Genes, physical fitness and ageing. Ageing Res Rev. 2013 Jan,12(1):90-102.
McCole SD et al. Beta2- and beta3-adrenergic receptor polymorphisms and exercise hemodynamics in postmenopausal women. J Appl Physiol (1985).
2004 Feb,96(2):526-30.
Moore GE et al. Obesity gene variant and elite endurance performance. Metabolism. 2001 Dec,50(12):1391-2.
ADRB2 adrenoceptor beta 2, surface (rs1042713)
The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a beta-adrenergic receptor within a cell membrane
which reacts with adrenaline (epinephrine) as a hormone or neurotransmitter affecting muscles or organs. The ADRB2 gene is
intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal
asthma, excessive weight and type 2 diabetes. This receptor is directly associated with one of its ultimate effectors, the class C L-
type calcium channel CaV1.2. This receptor-channel complex is coupled to the Gs G protein, which activates adenylyl cyclase,
catalysing the formation of cyclic adenosine monophosphate (cAMP) which then activates protein kinase A, and the
counterbalancing phosphatase PP2A.
RES Genotype POP Possible results
A/A 22% Increased maximal oxygen uptake (VO2max)
X A/G 51% Increased maximal oxygen uptake (VO2max)
References
G/G 27% No increased maximal oxygen uptake (VO2max)
Wagoner LE et al. Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure. Circ Res. 2000 Apr
28,86(8):834-40.
Wolfarth B et al. Association between a beta2-adrenergic receptor polymorphism and elite endurance performance. Metabolism. 2007
Dec,56(12):1649-51.
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