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Col1A1 - Collagen, type I, alpha 1 (rs1800012) The protein encoded by the COL1A1 gene (collagen, type I, alpha 1) is a fibrillary collagen and constitutes the major protein component of many connective tissues like ligaments and tendons, for example. Type 1 collagen is important for the structure and strength, as well as for the interaction with other parts of the extracellular matrix. Defects in the COL1A1 gene’s structure can lead to a modification of this connective tissue. RES Genotype POP Possible results G/G 81% No increased protection against injuries G/T 17% No increased protection against injuries X T/T 2% Increased protection against injuries References Collins M et al. Genetic risk factors for musculoskeletal soft tissue injuries. Med Sport Sci. 2009,54:136-49. Collins M et al. The COL1A1 gene and acute soft tissue ruptures. Br J Sports Med. 2010 Nov,44(14):1063-4. Maffulli N et al. The genetics of sports injuries and athletic performance. Muscles Ligaments Tendons J. 2013 Aug 11,3(3):173-89. Khoschnau S et al. Type I collagen alpha1 Sp1 poly-morphism and the risk of cruciate ligament ruptures or shoulder dislocations. Am J Sports Med 2008, 36:2432–2436. Posthumus M et al. Genetic risk factors for anterior cru-ciate ligament ruptures: COL1A1 gene variant. Br J Sports Med 2009,43:352–356. Col5A1 - Collagen, type V, alpha 1 (rs12722) The protein encoded by the COL5A1 gene (collagen, type V, alpha 1) is a fibrillary collagen and is found especially in connective tissue like ligaments and tendons that are composed of up to 10% of the collagen. Defects in this gene are associated with tendon and ligament damage. RES Genotype POP Possible results T/T 25% No increased protection against injuries T/C 64% No increased protection against injuries X C/C 11% Increased protection against injuries References Collins M et al. Genetic risk factors for musculoskeletal soft tissue injuries. Med Sport Sci. 2009,54:136-49. September AV et al. Variants within the COL5A1 gene are associated with Achilles tendinopathy in two populations. Br J Sports Med. 2009 May,43(5):357-65. Collins M et al. The COL5A1 genotype is associated with range of motion measurements. Scand J Med Sci Sports. 2009 Dec,19(6):803-10. Maffulli N et al. The genetics of sports injuries and athletic performance. Muscles Ligaments Tendons J. 2013 Aug 11,3(3):173-89. Mokone GG et al. The COL5A1 gene and Achilles tendon pathology. Scand J Med Sci Sports. 2006 Feb,16(1):19-26. DEMO_ML Page 273 of 295
BODY WEIGHT GENES YOUR NUTRITION TYPE TO LOSE WEIGHT YOUR SPORTS TYPE FOR LOSING WEIGHT YOUR WEIGHT LOSS PROGRAM YOUR SPORTS PROGRAM TO LOSE WEIGHT NUTRITION GENES FOOD INGREDIENTS DIETARY SUPPLEMENT EPIGENETICS DETOXIFICATION BIOLOGICAL AGE BURNOUT MUSCLE FIBRE TYPE OXIDATIVE STRESS AND RISK OF INJURY OPTIMAL PERFORMANCE NUTRITION FOOD LIST SCIENCE ADDITIONAL INFORMATION
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Lifestyle genetic analysis Maria Mu
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Lifestyle genetic analysis Personal
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BODY WEIGHT GENES An analysis and l
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physical activity / calorie reducti
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BODY WEIGHT GENES YOUR NUTRITION TY
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ANALYSIS OF TYPE Carbohydrate or fa
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Diet: Balanced diet: carbohydrates
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Your Type: MODERATE CALORY INTAKE T
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ANALYSIS OF STRATEGY Muscles, calor
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SETTING GOALS Your genetic weight l
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NUTRITION Dieting rules Can I cheat
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- - NutriMe Weight Management Your
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WEIGHT ICONS Losing weight with the
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- - Cookbook Menu plans and recipes
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- - The Menu Portal What it contain
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LOSING WEIGHT WITH THE HELP OF THE
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Step 3) How do you follow these gui
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Step 6) How does the food item syst
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LOSING WEIGHT WITH THE HELP OF THE
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Menu plan: Traditional Meal Item We
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Menu plan: Italian Meal Item Weight
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Menu plan: Oriental Meal Item Weigh
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Snacks, that can be eaten any time
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EXERCISE Exercise The goal of aerob
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Example of a training plan with 3 s
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Leisure activities and housework Tr
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EXERCISE Adjustment phase and stabi
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Leisure activities and housework Tr
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Determining your optimal heart rate
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NUTRITION GENES How your genes infl
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Your Result RESULT You have chosen
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Nutritional Genes - Milk SYMBOL rs
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FOOD INGREDIENTS The effects of ind
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NUTRIGENETICS Nutritional Genes - H
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NUTRIGENETICS Nutritional Genes - V
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Nutritional Genes - Oxidative Stres
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NUTRIGENETICS Nutritional Genes - B
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NUTRIGENETICS Nutritional Genes - B
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NUTRIGENETICS Nutritional Genes - C
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NUTRIGENETICS Nutritional Genes - E
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Summary ß-carotene ß-Carotene ß-
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Summary Magnesium Magnesium Magnesi
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Summary Oxalic acid Oxalic a. Oxali
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Summary Lactose Lactose Lactose Lac
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Alcohol Alcohol is a substance that
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Sucrose This sugar contains calorie
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TABLE How food types are evaluated
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and accurate list of ingredients. A
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DIETARY SUPPLEMENT This chapter des
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This chart shows the shortage of im
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EPIGENETICS Epigenetics - Regulatio
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How one's lifestyle can affect epig
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METABOLISM Phase 1 Detoxification f
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METABOLISM Oxidative stress and fre
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METABOLISM Substances and risks Eve
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Nutritional Genes - Oxidative Stres
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METABOLISM Prevention PHASE 2 DETOX
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Telomeres and biological age BIOLOG
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adapted diet as best as possible. Y
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BIOLOGICAL AGE Prevention What can
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STRESS AND BURNOUT SYNDROME Stress
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STRESS Genes relevant to stress Sev
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Lack of close, supportive relations
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How you should exercise Exercise re
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Athletics gene 1 (ACTN3 SNP rs18157
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Summary of the genetic predispositi
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VO2max Maximal oxygen uptake Cells
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VO2max Result OXYGEN UPTAKE (VO2max
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OXIDATIVE STRESS Athletes produce c
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Summary of effects ➤ You have a s
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INFLAMMATORY RESPONSE AND INJURY Ce
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Summary of effects ➤ The aggressi
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RECOVERY PHASE This chapter gives y
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CALORIES Ideal calorie distribution
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CALORIC DISTRIBUTION Your optimal c
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the order form and no genes are tes
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SCHEDULE The schedule of the perfor
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COMPETITIONS Competition diet The d
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Strategic plan for your athletic ca
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FOOD LIST This individual food list
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Green apple icons Green apple icons
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g per item F Recommendations to los
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Page 280: g per item F Recommendations to los
Page 293 and 294: BODY WEIGHT GENES YOUR NUTRITION TY
Page 295 and 296: SCIENCE The science of genes and ex
Page 297 and 298: Statement 4 Genes influence how our
Page 299 and 300: Weight loss program FABP2 - Fatty a
Page 301 and 302: ADRB2 adrenoceptor beta 2, surface
Page 303 and 304: APOA5 - Apolipoprotein A-V (rs66279
Page 305 and 306: Shiwaku K, Nogi A, Anuurad E, Kitaj
Page 307 and 308: ➤ GFHEV-Leitlinien. ➤ Gidh-Jain
Page 309 and 310: SCIENCE Epigenetics ➤ AAPS J. 201
Page 311 and 312: Detoxification SCIENCE CYP1A1 - Cyt
Page 313 and 314: GSTT1 - glutathione S-transferase t
Page 315 and 316: COMT - Catechol-O-methyltransferase
Page 317 and 318: PPARG (rs1801282) RES Genotype POP
Page 319 and 320: Athletic performance Angiotensin co
Page 321 and 322: Maximal oxygen uptake (VO2max) Nucl
Page 323 and 324: CRP - C-Reactive Protein (rs3093066
Page 325 and 326: GSTT1 - glutathione S-transferase t
Page 327 and 328: SCIENCE Inflammation and risk of in
Page 329: IL6R - interleukin 6 receptor (rs22
Page 333 and 334: - - NutriMe Complete How it works E
Page 335 and 336: - - Optimized absorption into the b
Page 337 and 338: - - NutriMe Complete - Proper care
Page 339 and 340: - - NutriMe Complete - The highest
Page 341 and 342: - - Effect of your individual micro
Page 343 and 344: - - Your daily requirement of micro
Page 345 and 346: - - Follow us on facebook! Follow u
Page 347 and 348: VERSION HISTORY Science continues t
Page 349 and 350: ➤ V455 - Layout improvements, Des
Page 351 and 352: CUSTOMER SERVICE Customer Service Q
Page 353 and 354: NOTES:
Page 355: 0000000000000 Lifestyle genetic ana
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