ProVitalDNA - Package - DEMO EN

SCIENCE
The science of genes and excessive weight
So far, several genes have been identified that affect body weight and determine which
diet will be most effective for an individual.
We have examined each of those genes in your analysis. Our method examines specific regions
of genes, called SNPs, for traits that determine your predisposition to becoming overweight
and the best weight loss strategy.
Summary of the science
This genetic analysis is supported by unusually strong scientific evidence. The genes have already been examined in
numerous scientific studies such as more than 7500 studies on the PPARG gene, 167 studies on the FABP2 gene, 6897
studies on the ADRB2 gene and 493 studies on FTO. This genetic weight loss program is based on the 53 most important
studies examining the effect of genes on weight loss and nutrition. This genetic test analysed 8 genetic variations that
have different effects on the body and is one of the most comprehensive genetic tests of this kind worldwide.
As there are 53 different scientific studies involved in this program, this short review focuses on the most important
claims only:
➤ Genetic polymorphisms cause people to react in different ways to the fat and the carbohydrates they eat. It is
helpful to only eat amounts of fat and carbohydrates that work best with your genetic profile.
➤ People following a weight loss program adapted to their genetic profile tend to show a 2.5 times greater
weight loss success than people following a standard dieting program.
➤ Genetic polymorphisms influence how the body responds to exercise for weight loss.
➤ Genetic differences influence how the body reacts to calorie reduction for losing weight.
The program detects the genetic programming, adjusts the calorie distribution accordingly and sets the focus on the
strategy that yields the best results. More exercise or fewer calories? The aim of this section is to provide evidence for
each of these statements, and to set the scientific basis of this program.
Statement 1
People react differently to the fat content of their diet. The adjustment of the fat content in the diet
may have a positive impact.
One very interesting study with 720 subjects (Robitaille et al., Clin Genet 63: 109-116, 2003) showed that only people with
an unfavorable variant of the PPARG gene (Pro12Ala) gained weight on a high-fat diet. This genetic impact has been
confirmed in an independent study by another research group (Memisoglu et al., Human Molecular Genetics 12:
2923-2929, 2001). Thus, a genetic analysis can predict the body's response to a high-fat or low-fat diet.
16 Publications
➤ http://www.jbc.org/content/276/43/39679.long J Biol Chem. 2001 Oct 26;276(43):39679-84. Epub 2001 Aug 3. The polymorphism at codon 54 of the
FABP2 gene increases fat absorption in human intestinal explants. Levy E, Ménard D, Delvin E, Stan S, Mitchell G, Lambert M, Ziv E, Feoli-Fonseca
JC, Seidman E.
➤ http://ajcn.nutrition.org/content/90/6/1483.long Am J Clin Nutr. 2009 Dec;90(6):1483-8. Epub 2009 Oct 14. The FTO gene rs9939609 obesity-risk
allele and loss of control over eating. Tanofsky-Kraff M, Han JC, Anandalingam K, Shomaker LB, Columbo KM, Wolkoff LE, Kozlosky M, Elliott C,
Ranzenhofer LM, Roza CA, Yanovski SZ, Yanovski JA.
➤ http://ajcn.nutrition.org/content/90/5/1418.long Am J Clin Nutr. 2009 Nov;90(5):1418-25. Epub 2009 Sep 2. Fat and carbohydrate intake modify
the association between genetic variation in the FTO genotype and obesity. Sonestedt E, Roos C, Gullberg B, Ericson U, Wirfält E, Orho-Melander
M.
➤ http://www.ncbi.nlm.nih.gov/pubmed/?term=19901143 Arch Intern Med. 2009 Nov 9;169(20):1897-906. APOA2, dietary fat, and body mass index:
replication of a gene-diet interaction in 3 independent populations. Corella D, Peloso G, Arnett DK, Demissie S, Cupples LA, Tucker K, Lai CQ,
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