ProVitalDNA - Package - DEMO EN

Col1A1 - Collagen, type I, alpha 1 (rs1800012)
The protein encoded by the COL1A1 gene (collagen, type I, alpha 1) is a fibrillary collagen and constitutes the major protein
component of many connective tissues like ligaments and tendons, for example. Type 1 collagen is important for the structure
and strength, as well as for the interaction with other parts of the extracellular matrix. Defects in the COL1A1 gene’s structure can
lead to a modification of this connective tissue.
RES Genotype POP Possible results
G/G 81% No increased protection against injuries
G/T 17% No increased protection against injuries
X T/T 2% Increased protection against injuries
References
Collins M et al. Genetic risk factors for musculoskeletal soft tissue injuries. Med Sport Sci. 2009,54:136-49.
Collins M et al. The COL1A1 gene and acute soft tissue ruptures. Br J Sports Med. 2010 Nov,44(14):1063-4.
Maffulli N et al. The genetics of sports injuries and athletic performance. Muscles Ligaments Tendons J. 2013 Aug 11,3(3):173-89.
Khoschnau S et al. Type I collagen alpha1 Sp1 poly-morphism and the risk of cruciate ligament ruptures or shoulder dislocations. Am J Sports Med
2008, 36:2432–2436.
Posthumus M et al. Genetic risk factors for anterior cru-ciate ligament ruptures: COL1A1 gene variant. Br J Sports Med 2009,43:352–356.
Col5A1 - Collagen, type V, alpha 1 (rs12722)
The protein encoded by the COL5A1 gene (collagen, type V, alpha 1) is a fibrillary collagen and is found especially in connective
tissue like ligaments and tendons that are composed of up to 10% of the collagen. Defects in this gene are associated with tendon
and ligament damage.
RES Genotype POP Possible results
T/T 25% No increased protection against injuries
T/C 64% No increased protection against injuries
X C/C 11% Increased protection against injuries
References
Collins M et al. Genetic risk factors for musculoskeletal soft tissue injuries. Med Sport Sci. 2009,54:136-49.
September AV et al. Variants within the COL5A1 gene are associated with Achilles tendinopathy in two populations. Br J Sports Med. 2009
May,43(5):357-65.
Collins M et al. The COL5A1 genotype is associated with range of motion measurements. Scand J Med Sci Sports. 2009 Dec,19(6):803-10.
Maffulli N et al. The genetics of sports injuries and athletic performance. Muscles Ligaments Tendons J. 2013 Aug 11,3(3):173-89.
Mokone GG et al. The COL5A1 gene and Achilles tendon pathology. Scand J Med Sci Sports. 2006 Feb,16(1):19-26.
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