공개특허 10-2011-01<strong>12</strong>308 백혈병, 식도 암, 감각신경모세포종, 유잉 계통 종양, 유잉 계통 육종, 유잉 육종, 두개외 생식세포 종양, 생식 샘외 생식세포 종양, 간외 담도 암, 유방외성 파제트병, 난관 암, 태아속 태아, 섬유종, 섬유육종, 소포성 림프 종, 소포성 갑상선 암, 담낭 암, 담낭 암, 신경절교종, 신경절신경종, 위 암, 위 림프종, 위장 암, 위장 유암종, 위장 기질 종양, 위장 기질 종양, 생식세포 종양, 배세포종, 임신성 융모막암종, 임신성 융모성 종양, 뼈의 거대 세포 종양, 다형성교모세포종, 신경교종, 대뇌신경교종증, 사구 종양, 글루카곤종, 생식아세포종, 과 립층 세포 종양, 모상 세포 백혈병, 모상 세포 백혈병, 두경부 암, 두경부 암, 심장 암, 혈관모세포종, 혈관주 위세포종, 혈관육종, 혈액학적 악성, 간세포 암종, 간비 T-세포 림프종, 유전성 유방-난소암 증후군, 호지킨 림 프종, 호지킨 림프종, 하인두 암, 시상하부 신경교종, 염증 유방암, 안구내 흑색종, 섬 세포 암종, 섬 세포 종 양, 연소형 골수단구성 백혈병, 카포시 육종, 카포시 육종, 신장 암, 클라츠킨씨 종양, 크루켄버그 종양, 후두 암, 후두 암, 악성 흑자 흑색종, 백혈병, 백혈병, 입술과 구강 암, 지방육종, 폐암, 황체종, 림프관종, 림프관 육종, 림프상피종, 림프성 백혈병, 림프종, 마크로글로불린혈증, 악성 섬유성 조직구종, 악성 섬유성 조직구종, 뼈의 악성 섬유성 조직구종, 악성 신경교종, 악성 중피종, 악성 말초신경초 종양, 악성 횡문근양 종양, 악성 트 리톤 종양, MALT 림프종, 덮개 세포 림프종, 비만 세포 백혈병, 종격동 생식세포 종양, 종격동 종양, 갑상선 수 질암, 속질모세포종, 속질모세포종, 속질상피종, 흑색종, 흑색종, 수막종, 메르켈 세포 암종, 중피종, 중피종, 잠복원발성 전이성 편평 목 암, 전이성 요로상피 암종, 혼합 뮬러 종양, 단구성 백혈병, 구강 암, 점액 종양, 다발성 캐슬만씨 병, 다발성 내분비 종양 증후군, 다발성 골수종, 다발성 골수종, 균상식육종, 균상식육종, 골 수형성이상 질환, 골수형성이상 증후군, 골수성 백혈병, 골수성 육종, 골수증식 질환, 점액종, 비강 암, 코인두 암, 코인두 암종, 신생물, 신경집종, 신경모세포종, 신경모세포종, 신경섬유종, 신경종, 결절성 흑색종, 비-호 지킨 림프종, 비-호지킨 림프종, 비-흑색종 피부 암, 비-소세포 폐암, 안종양, 희소별아교세포종, 핍지교종, 호 산성세포종, 시신경초 수막종, 구강 암, 구강 암, 입인두 암, 골육종, 골육종, 난소암, 난소암, 난소 상피 암, 난소 생식세포 종양, 난소 저급성 악성 종양, 유방의 파제트병, 판코스트 종양, 췌장암, 췌장암, 갑상샘 유두 암, 유두종증, 곁신경절종, 부비동 암, 부갑상선 암, 음경 암, 혈관주위 상피모양 세포 종양, 인두 암, 갈색세 포종, 중간 분화의 송과체 실질 종양, 송과체모세포종, 하수체세포종, 뇌하수체 선종, 뇌하수체 종양, 플라스마 세포 신생물, 흉막폐아세포종, 다배아종, 전구 T-림프모구성 림프종, 원발성 중추신경계 림프종, 원발성 삼출성 림프종, 원발성 간세포 암, 원발성 간 암, 원발성 복막 암, 원시 신경외배엽 종양, 전립선암, 복막가성점액종, 직장 암, 신장 세포 암종, 염색체 15에서 NUT 유전자가 관련된 호흡기 암종, 망막모세포종, 횡문근종, 횡문근육 종, 리히터 변형, 천미골 기형종, 타액선 암, 육종, 다발성신경초종, 피지선 암종, 속발성 신생물, 정상피종, 장액 종양, 세르톨리 라이디히 세포 종양, 성삭-기질 종양, 세자리 증후군, 인환 세포 암종, 피부 암, 청색 소 원형세포 종양, 소세포 암종, 소세포 폐암, 소세포 림프종, 소장 암, 연부 조직 육종, 소마토스타틴종, 매연 사 마귀, 척추 종양, 척추 종양, 비장 번연 림프종, 편평 세포 암종, 위 암, 표재 확장성 흑색종, 천막위 원시 신 경외배엽 종양, 표면 상피-기질 종양, 활액 육종, T-세포 급성 림프모구성 백혈병, T-세포 큰 과립성 림프구 백 혈병, T-세포 백혈병, T-세포 림프종, T-세포 전림프성 백혈병, 기형종, 말기 림프성 암, 고환 암, 난포막종, 인후 암, 흉선 암종, 가슴샘종, 갑상선 암, 신우 요관의 이행 세포 암, 이행 세포 암종, 요막관 암, 요도 암, 비뇨생식기 신생물, 자궁 육종, 포도막 흑색종, 질 암, 버너-모리슨 증후군, 사마귀모양 암종, 시각경로 신경교 종, 외음부 암, 왈덴스트룀 마크로글로불린혈증, 바르틴 종양, 윌름 종양, 또는 이들의 임의의 조합, 그리고 암 화학요법에서 약물 내성 및 암 화학요법 독성이 포함되지만 이들에 국한되지 않는다(참조: Hirata T, et al, Humanized anti-interleukin-6 receptor monoclonal antibody induced apoptosis of fresh and cloned human myeloma cells in vitro, Leuk Res., 2003 Apr;27(4):343-9, Bataille R, et al, Biologic effects of anti- interleukin-6 murine monoclonal antibody in advanced multiple myeloma, Blood, <strong>19</strong>95 Jul 15;86 (2):685- 91; Goto H, et al, Mouse anti-human interleukin-6 receptor monoclonal antibody inhibits proliferation of fresh human myeloma cells in vitro, Jpn J Cancer Res., <strong>19</strong>94 Sep;85(9):958-65; Klein B, et al, Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia, Blood, <strong>19</strong>91 Sep 1;78(5):1<strong>19</strong>8-204; Mauray S, et al, Epstein-Barr virus-dependent lymphoproliferative disease: critical role of IL-6, Eur J Immunol., 2000 Jul;30(7):2065-73; Tsunenari T, et al, New xenograft model of multiple myeloma and efficacy of a humanized antibody against human interleukin-6 receptor, Blood, <strong>19</strong>97 Sep 15;90(6):2437-44; Emilie D, et al, Interleukin-6 production in high-grade B lymphomas: correlation with the presence of malignant immunoblasts in acquired immunodeficiency syndrome and in human immunodeficiency virus-seronegative patients, Blood, <strong>19</strong>92 Jul 15;80(2):498-504; Emilie D, et al, Administration of an anti-interleukin-6 monoclonal antibody to patients with acquired immunodeficiency syndrome and lymphoma: effect on lymphoma growth and on B clinical Symptoms, Blood, <strong>19</strong>94 Oct 15; 84(8):2472-9; Smith PC, et al, Anti-interleukin-6 monoclonal antibody induces regression of human - 104 -
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특허청구의 범위 청구항 1
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- Page 133 and 134: [0944] [0945] [0946] [0947] [0948]
- Page 135 and 136: [0976] [0977] [0978] [0979] [0980]
- Page 137 and 138: [1033] [1034] [1035] [1036] [1037]
- Page 139 and 140: [1091] [1092] [1093] [1094] [1095]
- Page 141 and 142: [1152] [1153] [1154] [1155] [1156]
- Page 143 and 144: [1210] [1211] [1212] [1213] [1214]
- Page 145 and 146: [1271] [1272] [1273] [1274] [1275]
- Page 147 and 148: [1331] [1332] [1333] [1334] [1335]
- Page 149 and 150: [1391] [1392] [1393] [1394] [1395]
- Page 151 and 152: [1452] [1453] [1454] [1455] [1456]
- Page 153 and 154: [1514] [1515] [1516] [1517] [1518]
- Page 155 and 156:
[1575] [1576] [1577] [1578] [1579]
- Page 157 and 158:
[1635] [1636] [1637] [1638] [1639]
- Page 159 and 160:
[1695] [1696] [1697] [1698] [1699]
- Page 161 and 162:
[1756] [1757] [1758] [1759] [1760]
- Page 163 and 164:
[1817] [1818] [1819] [1820] [1821]
- Page 165 and 166:
[1877] [1878] [1879] [1880] [1881]
- Page 167 and 168:
[1937] [1938] [1939] [1940] [1941]
- Page 169 and 170:
[1997] [1998] [1999] [2000] [2001]
- Page 171 and 172:
[2059] [2060] [2061] [2062] [2063]
- Page 173 and 174:
[2121] [2122] [2123] [2124] [2125]
- Page 175 and 176:
[2177] [2178] [2179] [2180] [2181]
- Page 177 and 178:
[2249] [2250] [2251] [2252] [2253]
- Page 179 and 180:
[2302] [2303] [2304] [2305] [2306]
- Page 181 and 182:
[2344] [2345] [2346] [2347] [2348]
- Page 183 and 184:
[2378] [2379] [2380] [2381] [2382]
- Page 185 and 186:
[2418] [2419] [2420] [2421] 서열
- Page 187 and 188:
도면2 - 187 - 공개특허 10-201
- Page 189 and 190:
도면4 - 189 - 공개특허 10-201
- Page 191 and 192:
도면6 - 191 - 공개특허 10-201
- Page 193 and 194:
도면8 - 193 - 공개특허 10-201
- Page 195 and 196:
도면10a - 195 - 공개특허 10-2
- Page 197 and 198:
도면10c - 197 - 공개특허 10-2
- Page 199 and 200:
도면10e - 199 - 공개특허 10-2
- Page 201 and 202:
도면12 - 201 - 공개특허 10-20
- Page 203 and 204:
도면14 - 203 - 공개특허 10-20
- Page 205 and 206:
도면16 - 205 - 공개특허 10-20
- Page 207 and 208:
도면18 - 207 - 공개특허 10-20
- Page 209 and 210:
도면20 - 209 - 공개특허 10-20
- Page 211 and 212:
도면22 - 211 - 공개특허 10-20
- Page 213 and 214:
도면24 - 213 - 공개특허 10-20
- Page 215 and 216:
도면26a 도면26b - 215 - 공개
- Page 217 and 218:
도면28 - 217 - 공개특허 10-20
- Page 219 and 220:
도면30 도면31 - 219 - 공개특
- Page 221 and 222:
도면33 - 221 - 공개특허 10-20
- Page 223 and 224:
도면35 - 223 - 공개특허 10-20
- Page 225 and 226:
도면36b - 225 - 공개특허 10-2
- Page 227 and 228:
도면37b - 227 - 공개특허 10-2
- Page 229 and 230:
도면39 - 229 - 공개특허 10-20
- Page 231 and 232:
도면41 - 231 - 공개특허 10-20
- Page 233 and 234:
도면43 - 233 - 공개특허 10-20
- Page 235 and 236:
도면45 - 235 - 공개특허 10-20
- Page 237 and 238:
도면47 - 237 - 공개특허 10-20
- Page 239 and 240:
도면49 - 239 - 공개특허 10-20
- Page 241 and 242:
도면51 - 241 - 공개특허 10-20
- Page 243 and 244:
도면53 - 243 - 공개특허 10-20
- Page 245 and 246:
도면56 도면57 - 245 - 공개특
- Page 247 and 248:
도면60 도면61 - 247 - 공개특
- Page 249 and 250:
Smith, Jeffrey T.L. Schatzman, Rand
- Page 251 and 252:
Leu Pro Gly Ala Arg Cys Ala Tyr Asp
- Page 253 and 254:
PRT Oryctolagus cuniculus 6 Gln G
- Page 255 and 256:
agggcatcca ctctggcatc t 21 14 36
- Page 257 and 258:
99 PRT Oryctolagus cuniculus 20
- Page 259 and 260:
100 105 110 Val Arg Gly Gly Ala Val
- Page 261 and 262:
501 DNA Oryctolagus cuniculus 30
- Page 263 and 264:
85 90 95 Leu Thr Ile Thr Asp Val Gl
- Page 265 and 266:
1 5 43 16 PRT Oryctolagus cunic
- Page 267 and 268:
gtctactaca tgaac 15 51 48 DNA O
- Page 269 and 270:
145 150 155 160 Ala Leu Gly Cys Leu
- Page 271 and 272:
gagcagctga aggagtccgg aggaggcctg gt
- Page 273 and 274:
Val Val Val Lys Arg Thr Val Ala Ala
- Page 275 and 276:
75 Ile Ile Gly Gly Phe Gly Thr Thr
- Page 277 and 278:
Oryctolagus cuniculus 83 atcattggt
- Page 279 and 280:
12 PRT Oryctolagus cuniculus 87
- Page 281 and 282:
tgggcgaaag gccgattcac catctccaaa ac
- Page 283 and 284:
145 150 155 160 Leu Asn Asn Phe 10
- Page 285 and 286:
108 12 PRT Oryctolagus cuniculus
- Page 287 and 288:
36 DNA Oryctolagus cuniculus 116
- Page 289 and 290:
PRT Oryctolagus cuniculus 120 Ile
- Page 291 and 292:
125 Glu Ile Ser Lys Leu Glu Ser 1 5
- Page 293 and 294:
133 gaaatatcca aactggaatc t 21 134
- Page 295 and 296:
100 105 110 Val Arg Ser Leu Lys Tyr
- Page 297 and 298:
gcgaaaggcc gattcaccat ctccaagacc tc
- Page 299 and 300:
1 5 10 15 Val Gln Cys Gln Ser Val G
- Page 301 and 302:
gtcaccatca gttgccagtc cagtcagagt gt
- Page 303 and 304:
50 55 60 Gly Gln Arg Pro Lys Leu Le
- Page 305 and 306:
177 8 PRT Oryctolagus cuniculus
- Page 307 and 308:
aattatggtg gtgatgaaag tttg 24 186
- Page 309 and 310:
6 PRT Oryctolagus cuniculus 191
- Page 311 and 312:
Oryctolagus cuniculus 199 agcggcta
- Page 313 and 314:
205 7 PRT Oryctolagus cuniculus
- Page 315 and 316:
213 21 DNA Oryctolagus cuniculus
- Page 317 and 318:
65 70 75 80 Ala Lys Gly Arg Phe Thr
- Page 319 and 320:
399 DNA Oryctolagus cuniculus 22
- Page 321 and 322:
100 105 110 Leu Gly Ser Tyr Asp Cys
- Page 323 and 324:
Ala Tyr Asp Leu 1 242 375 DNA O
- Page 325 and 326:
Met Asp Thr Arg Ala Pro Thr Gln Leu
- Page 327 and 328:
1 5 256 16 PRT Oryctolagus cuni
- Page 329 and 330:
DNA Oryctolagus cuniculus 264 ttc
- Page 331 and 332:
Trp Ala Ser Thr Leu Ala Ser 1 5 27
- Page 333 and 334:
278 33 DNA Oryctolagus cuniculus
- Page 335 and 336:
284 11 PRT 115 120 125 Oryctolag
- Page 337 and 338:
tacgcgagtt gggcgaaagg ccgattcacc at
- Page 339 and 340:
1 5 10 15 Val Gln Cys Gln Ser Val G
- Page 341 and 342:
aaaccagggc agcctcccaa gctcctgatc ta
- Page 343 and 344:
65 70 75 80 Gly Val Pro Ser Arg Phe
- Page 345 and 346:
321 16 PRT Oryctolagus cuniculus
- Page 347 and 348:
gtcattggcg atactgctgg ttatgcttat tt
- Page 349 and 350:
1 5 10 < 210> 335 5 PRT Oryctola
- Page 351 and 352:
343 15 DNA Oryctolagus cuniculus
- Page 353 and 354:
Oryctolagus cuniculus 348 Gln Ala
- Page 355 and 356:
Oryctolagus cuniculus 356 caggccag
- Page 357 and 358:
Ser Thr Tyr Tyr Ile Tyr Trp Val Arg
- Page 359 and 360:
gacctggagt gtgacgatgc tgccacttac ta
- Page 361 and 362:
Pro Ser Arg Phe Lys Gly Ser Gly Ser
- Page 363 and 364:
10 PRT Oryctolagus cuniculus 385
- Page 365 and 366:
124 PRT Oryctolagus cuniculus 39
- Page 367 and 368:
6 PRT Oryctolagus cuniculus 399
- Page 369 and 370:
DNA Oryctolagus cuniculus 407 agc
- Page 371 and 372:
1 5 10 413 7 PRT Oryctolagus cu
- Page 373 and 374:
421 21 DNA Oryctolagus cuniculus
- Page 375 and 376:
65 70 75 80 Ala Lys Gly Arg Phe Thr
- Page 377 and 378:
atggagactg ggctgcgctg gcttctcctg gt
- Page 379 and 380:
127 PRT Oryctolagus cuniculus 44
- Page 381 and 382:
450 atggacacga gggcccccac tcagctgct
- Page 383 and 384:
Val Ser Ala Ala Val Gly Gly Thr Val
- Page 385 and 386:
Ile Ile Ala Asn Ser Gly Thr Thr Phe
- Page 387 and 388:
DNA Oryctolagus cuniculus 473 gag
- Page 389 and 390:
478 Gln Gln Gly Ala Thr Val Tyr Asp
- Page 391 and 392:
487 15 DNA Oryctolagus cuniculus
- Page 393 and 394:
492 Gln Ala Ser Glu Asn Ile Tyr Ser
- Page 395 and 396:
500 caggccagtg agaacattta tagcttttt
- Page 397 and 398:
50 55 60 Trp Ile Gly Ile Ile Thr Gl
- Page 399 and 400:
Oryctolagus cuniculus 515 atggagac
- Page 401 and 402:
523 122 PRT 115 120 Oryctolagus
- Page 403 and 404:
DNA Oryctolagus cuniculus 530 atg
- Page 405 and 406:
20 25 30 Val Ser Val Pro Val Gly As
- Page 407 and 408:
Oryctolagus cuniculus 544 Phe Ile
- Page 409 and 410:
553 33 DNA Oryctolagus cuniculus
- Page 411 and 412:
Oryctolagus cuniculus 558 Gln Gln
- Page 413 and 414:
Oryctolagus cuniculus 566 caacaggg
- Page 415 and 416:
PRT Oryctolagus cuniculus 572 Gln
- Page 417 and 418:
DNA Oryctolagus cuniculus 580 cag
- Page 419 and 420:
aacaggggag agtgt 315 588 330 PRT
- Page 421 and 422:
tacgtggacg gcgtggaggt gcataatgcc aa
- Page 423 and 424:
15 PRT Homo sapiens 598 Asp Lys
- Page 425 and 426:
Ser Lys Glu Ala Leu Ala Glu Asn Asn
- Page 427 and 428:
15 PRT Homo sapiens 617 Cys Leu
- Page 429 and 430:
626 Glu Gln Ala Arg Ala Val Gln Met
- Page 431 and 432:
15 PRT Homo sapiens 636 Asp Pro
- Page 433 and 434:
645 Leu Arg Ser Phe Lys Glu Phe Leu
- Page 435 and 436:
PRT Homo sapiens 650 Asp Ile Gln
- Page 437 and 438:
20 25 30 Tyr Met Ser Trp Val Arg Gl
- Page 439 and 440:
65 70 75 80 Gln Met Asn Ser Leu Arg
- Page 441 and 442:
122 PRT Oryctolagus cuniculus 66
- Page 443 and 444:
gcaaaattta acttg 375 664 450 PRT
- Page 445 and 446:
450 665 450 PRT Oryctolagus cun
- Page 447 and 448:
Gly Lys 450 666 216 PRT Oryctol
- Page 449 and 450:
20 25 30 Pro Gly Thr Pro Leu Thr Le
- Page 451 and 452:
1 5 10 15 Val Gln Cys Gln Ser Leu G
- Page 453 and 454:
676 Met Glu Thr Gly Leu Arg Trp Leu
- Page 455 and 456:
PRT Oryctolagus cuniculus 680 Met
- Page 457 and 458:
684 128 PRT 115 120 Oryctolagus
- Page 459 and 460:
100 105 110 Gly Tyr Ser Leu Arg Asn
- Page 461 and 462:
85 90 95 Arg Asp Asp Ser Ser Asp Tr
- Page 463 and 464:
85 90 95 Arg Asp Asp Ser Ser Asp Tr
- Page 465 and 466:
85 90 95 Ile Asp Asn Ala Phe Gly Gl
- Page 467 and 468:
50 55 60 Ser Gly Ser Gly Thr Asp Ph
- Page 469 and 470:
Lys Val Tyr Ala Cys Glu Val Thr His
- Page 471 and 472:
195 200 205 Pro Ser Asn Thr Lys Val
- Page 473 and 474:
Leu Ile Tyr Arg Ala Ser Thr Leu Ala
- Page 475 and 476:
50 55 60 Trp Val Gly Ile Ile Tyr Gl
- Page 477 and 478:
35 40 45 Tyr Arg Ala Ser Thr Leu Al
- Page 479 and 480:
212> PRT Homo sapiens 718 Val Ile
- Page 481 and 482:
ttcagcggca gtggatctgg gacagacttc ac
- Page 483 and 484:
PRT Homo sapiens 726 Met Glu Lys
- Page 485 and 486:
210 215 220 Thr Ala Val Ala Arg Asn
- Page 487 and 488:
195 200 205 Ser Asp His Ile Asn Phe
- Page 489:
690 695 700 Pro Glu Asp Leu Lys Ser