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(19) 대한민국특허청(KR) (12) 공개특허공보(A) - Questel

(19) 대한민국특허청(KR) (12) 공개특허공보(A) - Questel

(19) 대한민국특허청(KR) (12) 공개특허공보(A) - Questel

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prostate cancer xenografts in nude mice, Prostate, 2001 Jun 15;48(1):47-53; Smith PC, et al,<br />

Interleukin-6 and prostate cancer progression, Cytokine Growth Factor Rev., 2001 Mar;<strong>12</strong>(1):33-40;<br />

Chung TD, et al, Characterization of the role of IL-6 in the progression of prostate cancer, Prostate,<br />

<strong>19</strong>99 Feb 15;38(3):<strong>19</strong>9-207; Okamoto M, et al, Interleukin-6 as a paracrine and autocrine growth factor<br />

in human prostatic carcinoma cells in vitro, Cancer Res., <strong>19</strong>97 Jan 1;57(1):141-6; Reittie JE, et al,<br />

Interleukin-6 inhibits apoptosis and tumor necrosis factor induced proliferation of B-chronic<br />

lymphocytic leukemia, Leuk Lymphoma, <strong>19</strong>96 Jun;22(1-2):83-90, follow 186, color plate VI; Sugiyama H,<br />

et al, The expression of IL-6 and its related genes in acute leukemia, Leuk Lymphoma, <strong>19</strong>96 Mar;21(1-<br />

2):49-52; Bataille R, et al, Effects of an anti-interleukin-6 (IL-6) murine monoclonal antibody in a<br />

patient with acute monoblastic leukemia, Med Oncol Tumor Pharmacother., <strong>19</strong>93;10(4):185-8; Kedar I, et<br />

al, Thalidomide reduces serum C-reactive protein and interleukin-6 and induces response to IL-2 in a<br />

fraction of metastatic renal cell cancer patients who failed IL-2-based therapy, Int J Cancer, 2004<br />

Jun 10;110(2):260-5; Angelo LS, Talpaz M, Kurzrock R, Autocrine interleukin-6 production in renal cell<br />

carcinoma: evidence for the involvement of p53, Cancer Res., 2002 Feb 1;62(3):932-40; Nishimoto N,<br />

Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease, Blood,<br />

2005 Oct 15;106(8):2627-32, Epub 2005 Jul 5; Katsume A, et al, Anti-interleukin 6 (IL-6) receptor<br />

antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice, Cytokine, 2002<br />

Dec 21;20(6):304-11; Nishimoto N, et al, Improvement in Castleman's disease by humanized anti-<br />

interleukin-6 receptor antibody therapy, Blood, 2000 Jan 1;95(1):56-61; Screpanti I, Inactivation of<br />

the IL-6 gene prevents development of multicentric Castleman's disease in C/EBP betamice, J Exp Med.,<br />

<strong>19</strong>96 Oct 1;184(4):1561-6; Hsu SM, et al, Expression of interleukin-6 in Castleman's disease, Hum<br />

Pathol., <strong>19</strong>93 Aug;24(8):833-9; Yoshizaki K, et al, Pathogenic significance of interleukin-6 (IL 6/BSF-<br />

2) in Castleman's disease, Blood, <strong>19</strong>89 Sep;74(4):1360-7; Nilsson MB, et al, Interleukin-6, secreted by<br />

human ovarian carcinoma cells, is a potent proangiogenic cytokine, Cancer Res., 2005 Dec<br />

1;65(23):10794-800; Toutirais O, et al, Constitutive expression of TGF-betal, interleukin-6 and<br />

interleukin-8 by tumor cells as a major component of immune escape in human ovarian carcinoma, Eur<br />

Cytokine Netw., 2003 Oct-Dec;14(4):246-55; Obata NH, et al, Effects of interleukin 6 on in vitro cell<br />

attachment, migration and invasion of human ovarian carcinoma, Anticancer Res., <strong>19</strong>97 Jan-Feb;17<br />

(lA):337-42; Dedoussis GV, et al, Endogenous interleukin 6 conveys resistance to cis-<br />

diamminedichloroplatinum-mediated apoptosis of the K562 human leukemic cell line, Exp Cell Res., <strong>19</strong>99<br />

Jun 15;249(2):269-78; Borsellino N, et al, Blocking signaling through the Gp130 receptor chain by<br />

interleukin-6 and oncostatin M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide<br />

and cisplatin-mediated cytotoxicity, Cancer, <strong>19</strong>99 Jan 1;85(1):134-44; Borsellino N, et al, Endogenous<br />

interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide-mediated<br />

cytotoxicity of human prostate carcinoma cell lines, Cancer Res., <strong>19</strong>95 Oct 15;55(20):4633-9; Mizutani<br />

Y, et al, Sensitization of human renal cell carcinoma cells to cis-diamminedichloroplatinum(II) by<br />

anti-interleukin 6 monoclonal antibody or anti-interleukin 6 receptor monoclonal antibody; Cancer<br />

Res., <strong>19</strong>95 Feb 1;55(3):590-6; Yusuf RZ, et al, Paclitaxel resistance: molecular mechanisms and<br />

pharmacologic manipulation, Curr Cancer Drug Targets, 2003 Feb;3(1):1-<strong>19</strong>; Duan Z, et al,<br />

Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-20S human osteosarcoma cells,<br />

Cytokine, 2002 Mar 7;17(5):234-42; Conze D, et al, Autocrine production of interleukin 6 causes<br />

multidrug resistance in breast cancer cells, Cancer Res., 2001 Dec 15;61(24):8851-8; Rossi JF, et al,<br />

Optimizing the use of anti-interleukin-6 monoclonal antibody with dexamethasone and 140 mg/m2 of<br />

melphalan in multiple myeloma: results of a pilot study including biological aspects, Bone Marrow<br />

Transplant, 2005 Nov;36(9):771-9; 그리고 Tonini G, et al, Oxaliplatin may induce cytokine-release<br />

syndrome in colorectal cancer patients, J BiolRegul Homeost Agents, 2002 Apr-Jun;16 (2):105-9; 이들 각<br />

각의 내용은 본 발명에 그 전체가 참조로서 편입된다).<br />

공개특허 10-2011-01<strong>12</strong>308<br />

본 발명의 또 다른 구체예에서, 본 명세서에서 기술된 항-IL-6 항체, 또는 이들의 단편 또는 변이체는 허혈성<br />

심장 질환, 동맥경화증, 비만, 당뇨병, 천식, 다발성 경화증, 알츠하이머병, 뇌혈관 질환, 발열, 급성기 반응,<br />

알레르기, 빈혈, 염증의 빈혈(만성 질환의 빈혈), 고혈압, 우울증, 만성 질환과 연관된 우울증, 혈전증, 혈소판<br />

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