(19) 대한민국특허청(KR) (12) 공개특허공보(A) - Questel

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[1483] [1484] [1485] [1486] [1487] [1488] [1489] [1490] [1491] [1492] [1493] [1494] [1495] [1496] [1497] [1498] [1499] [1500] [1501] [1502] [1503] [1504] [1505] [1506] [1507] [1508] [1509] [1510] [1511] [1512] [1513] ATGGAGACTGGGCTGCGCTGGCTTCTCCTGGTCGCTGTGCCCAAAGGTGTCCAGTGTCAGTCGCTGGAGGAGTCCGGGGGTCGCCTGGTCACGCCTGGGACA CCCCTGACACTCACCTGCACACTCTCTGGATTCTCCCTCAGTGCATACTATATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAATGGATCGGATTC ATTACTCTGAGTGATCATATATCTTACGCGAGGTGGGCGAAAGGCCGATTCACCATCTCCAAAACCTCGACCACGGTGGATCTGAAAATGACCAGTCCGACA ACCGAGGACACGGCCACCTATTTCTGTGCCAGGAGTCGTGGCTGGGGTGCAATGGGTCGGTTGGATCTC 서열 번호: 260 CAGGCCAGTCAGAGTGTTTATGACAACAACTATTTATCC 서열 번호: 261 GGTGCATCCACTCTGGCATCT 서열 번호: 262 GCAGGCGTTTTTAATGATGATAGTGATGATGCC 서열 번호: 263 GCATACTATATGAGC 서열 번호: 264 TTCATTACTCTGAGTGATCATATATCTTACGCGAGGTGGGCGAAAGGC 서열 번호: 265 AGTCGTGGCTGGGGTGCAATGGGTCGGTTGGATCTC 서열 번호: 266 MDTRAPTQLLGLLLLWLPGATFAAVLTQTPSPVSAAVGGTVTISCQASQSVYNNKNLAWYQQKSGQPPKLLIYWASTLASGVSSRFSGSGSGTQFTLTVSGV QCDDAATYYCLGVFDDDADNA 서열 번호: 267 METGLRWLLLVAVLKGVQCQSVEESGGRLVTPGTPLTLTCTASGFSLSSYSMTWVRQAPGKGLEYIGVIGTSGSTYYATWAKGRFTISRTSTTVALKITSPT TEDTATYFCVRSLSSITFL 서열 번호: 268 QASQSVYNNKNLA 서열 번호: 269 WASTLAS 서열 번호: 270 LGVFDDDADNA 서열 번호: 271 SYSMT 서열 번호: 272 VIGTSGSTYYATWAKG 서열 번호: 273 SLSSITFL 서열 번호: 274 공개특허 10-2011-0112308 ATGGACACGAGGGCCCCCACTCAGCTGCTGGGGCTCCTGCTGCTCTGGCTCCCAGGTGCCACATTCGCAGCCGTGCTGACCCAGACACCATCGCCCGTGTCT GCGGCTGTGGGAGGCACAGTCACCATCAGTTGCCAGGCCAGTCAGAGTGTTTATAACAACAAAAATTTAGCCTGGTATCAGCAGAAATCAGGGCAGCCTCCC AAGCTCCTGATCTACTGGGCATCCACTCTGGCATCTGGGGTCTCATCGCGGTTCAGCGGCAGTGGATCTGGGACACAGTTCACTCTCACCGTCAGCGGCGTG - 152 -
[1514] [1515] [1516] [1517] [1518] [1519] [1520] [1521] [1522] [1523] [1524] [1525] [1526] [1527] [1528] [1529] [1530] [1531] [1532] [1533] [1534] [1535] [1536] [1537] [1538] [1539] [1540] [1541] [1542] [1543] [1544] CAGTGTGACGATGCTGCCACTTACTACTGTCTAGGCGTTTTTGATGATGATGCTGATAATGCT 서열 번호: 275 ATGGAGACTGGGCTGCGCTGGCTTCTCCTGGTCGCTGTGCTCAAAGGTGTCCAATGTCAGTCGGTGGAGGAGTCCGGGGGTCGCCTGGTCACGCCTGGGACA CCCCTGACACTCACCTGCACAGCCTCTGGATTCTCCCTCAGTAGCTACTCCATGACCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAATATATCGGAGTC ATTGGTACTAGTGGTAGCACATACTACGCGACCTGGGCGAAAGGCCGATTCACCATCTCCAGAACCTCGACCACGGTGGCTCTGAAAATCACCAGTCCGACA ACCGAGGACACGGCCACCTATTTCTGTGTCAGGAGTCTTTCTTCTATTACTTTCTTG 서열 번호: 276 CAGGCCAGTCAGAGTGTTTATAACAACAAAAATTTAGCC 서열 번호: 277 TGGGCATCCACTCTGGCATCT 서열 번호: 278 CTAGGCGTTTTTGATGATGATGCTGATAATGCT 서열 번호: 279 AGCTACTCCATGACC 서열 번호: 280 GTCATTGGTACTAGTGGTAGCACATACTACGCGACCTGGGCGAAAGGC 서열 번호: 281 AGTCTTTCTTCTATTACTTTCTTG 서열 번호: 282 MDTRAPTQLLGLLLLWLPGARCAFELTQTPASVEAAVGGTVTINCQASQNIYRYLAWYQQKPGQPPKFLIYLASTLASGVPSRFKGSGSGTEFTLTISDLEC ADAATYYCQSYYSSNSVA 서열 번호: 283 METGLRWLLLVAVLKGVQCQEQLVESGGDLVQPEGSLTLTCTASELDFSSGYWICWVRQVPGKGLEWIGCIYTGSSGSTFYASWAKGRFTISKTSSTTVTLQ MTSLTAADTATYFCARGYSGFGYFKL 서열 번호: 284 QASQNIYRYLA 서열 번호: 285 LASTLAS 서열 번호: 286 QSYYSSNSVA 서열 번호: 287 SGYWIC 서열 번호: 288 CIYTGSSGSTFYASWAKG 서열 번호: 289 GYSGFGYFKL 서열 번호: 290 - 153 - 공개특허 10-2011-0112308
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(51) Int. Cl. (19) 대한민국특
Page 3 and 4:
특허청구의 범위 청구항 1
Page 5 and 6:
서열 번호: 5에 적어도 85.7%
Page 7 and 8:
청구항 1 내지 20중 어느 한
Page 9 and 10:
청구항 38 청구항 34에 있어
Page 11 and 12:
암(Pharyngeal Cancer), 갈색세
Page 13 and 14:
청구항 41에 있어서, Ab1 항
Page 15 and 16:
청구항 41에 있어서, 개체
Page 17 and 18:
청구항 103에 있어서, 항-IL-
Page 19 and 20:
톨페남산, 톨메틴, 발데콕
Page 21 and 22:
IFN-감마, BAFF, CXCL13, IP-10, VE
Page 23 and 24:
드, 또는 높은 엄밀도 조건
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서열 번호: 120에 적어도 50%
Page 27 and 28:
청구항 160 청구항 140 내지
Page 29 and 30:
약, 항히스타민제, 아프레
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탈리주맙, 네다플라틴, 네
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[0001] [0002] [0003] [0004] [0005]
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[0015] [0016] [0017] [0018] [0019]
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[0029] [0030] [0031] [0032] [0033]
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[0040] [0041] [0042] [0043] [0044]
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[0056] [0057] [0058] [0059] [0060]
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[0084] [0085] [0086] [0087] [0088]
Page 45 and 46:
[0100] [0101] [0102] [0103] [0104]
Page 47 and 48:
[0132] [0133] [0134] [0135] [0136]
Page 49 and 50:
[0171] [0172] [0173] [0174] [0175]
Page 51 and 52:
[0186] [0187] [0188] [0189] 한 참
Page 53 and 54:
[0197] [0198] [0199] [0200] [0201]
Page 55 and 56:
[0210] [0211] [0212] [0213] [0214]
Page 57 and 58:
[0228] [0229] [0230] [0231] [0232]
Page 59 and 60:
[0242] [0243] [0244] [0245] [0246]
Page 61 and 62:
[0254] [0255] [0256] [0257] [0258]
Page 63 and 64:
[0276] [0277] [0278] [0279] [0280]
Page 65 and 66:
[0301] [0302] [0303] [0304] [0305]
Page 67 and 68:
[0363] [0364] [0365] [0366] [0367]
Page 69 and 70:
[0405] [0406] [0407] [0408] [0409]
Page 71 and 72:
[0411] [0412] [0413] [0414] [0415]
Page 73 and 74:
[0425] [0426] [0427] [0428] [0429]
Page 75 and 76:
[0438] [0439] [0440] [0441] [0442]
Page 77 and 78:
[0455] [0456] [0457] [0458] [0459]
Page 79 and 80:
[0463] [0464] [0465] 333, 525 415,
Page 81 and 82:
[0474] [0475] [0476] [0477] [0478]
Page 83 and 84:
[0495] [0496] [0497] [0498] [0499]
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[0520] [0521] [0522] [0523] [0524]
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[0537] [0538] [0539] [0540] [0541]
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[0555] [0556] [0557] [0558] [0559]
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[0588] [0589] [0590] [0591] [0592]
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[0609] [0610] [0611] [0612] [0613]
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[0623] [0624] [0625] [0626] [0627]
Page 97 and 98:
[0641] [0642] [0643] [0644] [0645]
Page 99 and 100:
[0664] [0665] [0666] [0667] [0668]
Page 101 and 102: [0684] [0685] challenge to evaluate
Page 103 and 104: [0686] [0687] marrow transplantatio
Page 105 and 106: [0688] prostate cancer xenografts i
Page 107 and 108: [0689] [0690] [0691] [0692] [0693]
Page 109 and 110: [0699] [0700] [0701] [0702] [0703]
Page 111 and 112: 도 4에서는 인간 IL-6의 100
Page 113 and 114: [0718] [0719] [0720] [0721] [0722]
Page 115 and 116: [0737] [0738] [0739] [0740] [0741]
Page 117 and 118: [0751] [0752] [0753] [0754] [0755]
Page 119 and 120: [0771] [0772] [0773] [0774] [0775]
Page 121 and 122: [0793] [0794] [0795] [0796] [0797]
Page 123 and 124: [0815] [0816] [0817] [0818] [0819]
Page 125 and 126: [0838] [0839] [0840] [0841] [0842]
Page 127 and 128: [0868] [0869] [0870] [0871] [0872]
Page 129 and 130: [0893] [0894] [0895] [0896] [0897]
Page 131 and 132: [0917] [0918] [0919] [0920] [0921]
Page 133 and 134: [0944] [0945] [0946] [0947] [0948]
Page 135 and 136: [0976] [0977] [0978] [0979] [0980]
Page 137 and 138: [1033] [1034] [1035] [1036] [1037]
Page 139 and 140: [1091] [1092] [1093] [1094] [1095]
Page 141 and 142: [1152] [1153] [1154] [1155] [1156]
Page 143 and 144: [1210] [1211] [1212] [1213] [1214]
Page 145 and 146: [1271] [1272] [1273] [1274] [1275]
Page 147 and 148: [1331] [1332] [1333] [1334] [1335]
Page 149 and 150: [1391] [1392] [1393] [1394] [1395]
Page 151: [1452] [1453] [1454] [1455] [1456]
Page 155 and 156: [1575] [1576] [1577] [1578] [1579]
Page 157 and 158: [1635] [1636] [1637] [1638] [1639]
Page 159 and 160: [1695] [1696] [1697] [1698] [1699]
Page 161 and 162: [1756] [1757] [1758] [1759] [1760]
Page 163 and 164: [1817] [1818] [1819] [1820] [1821]
Page 165 and 166: [1877] [1878] [1879] [1880] [1881]
Page 167 and 168: [1937] [1938] [1939] [1940] [1941]
Page 169 and 170: [1997] [1998] [1999] [2000] [2001]
Page 171 and 172: [2059] [2060] [2061] [2062] [2063]
Page 173 and 174: [2121] [2122] [2123] [2124] [2125]
Page 175 and 176: [2177] [2178] [2179] [2180] [2181]
Page 177 and 178: [2249] [2250] [2251] [2252] [2253]
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Page 183 and 184: [2378] [2379] [2380] [2381] [2382]
Page 185 and 186: [2418] [2419] [2420] [2421] 서열
Page 187 and 188: 도면2 - 187 - 공개특허 10-201
Page 189 and 190: 도면4 - 189 - 공개특허 10-201
Page 191 and 192: 도면6 - 191 - 공개특허 10-201
Page 193 and 194: 도면8 - 193 - 공개특허 10-201
Page 195 and 196: 도면10a - 195 - 공개특허 10-2
Page 197 and 198: 도면10c - 197 - 공개특허 10-2
Page 199 and 200: 도면10e - 199 - 공개특허 10-2
Page 201 and 202: 도면12 - 201 - 공개특허 10-20
Page 203 and 204:
도면14 - 203 - 공개특허 10-20
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도면16 - 205 - 공개특허 10-20
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도면18 - 207 - 공개특허 10-20
Page 209 and 210:
도면20 - 209 - 공개특허 10-20
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도면22 - 211 - 공개특허 10-20
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도면24 - 213 - 공개특허 10-20
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도면26a 도면26b - 215 - 공개
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도면28 - 217 - 공개특허 10-20
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도면30 도면31 - 219 - 공개특
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도면33 - 221 - 공개특허 10-20
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도면35 - 223 - 공개특허 10-20
Page 225 and 226:
도면36b - 225 - 공개특허 10-2
Page 227 and 228:
도면37b - 227 - 공개특허 10-2
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도면39 - 229 - 공개특허 10-20
Page 231 and 232:
도면41 - 231 - 공개특허 10-20
Page 233 and 234:
도면43 - 233 - 공개특허 10-20
Page 235 and 236:
도면45 - 235 - 공개특허 10-20
Page 237 and 238:
도면47 - 237 - 공개특허 10-20
Page 239 and 240:
도면49 - 239 - 공개특허 10-20
Page 241 and 242:
도면51 - 241 - 공개특허 10-20
Page 243 and 244:
도면53 - 243 - 공개특허 10-20
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도면56 도면57 - 245 - 공개특
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도면60 도면61 - 247 - 공개특
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Smith, Jeffrey T.L. Schatzman, Rand
Page 251 and 252:
Leu Pro Gly Ala Arg Cys Ala Tyr Asp
Page 253 and 254:
PRT Oryctolagus cuniculus 6 Gln G
Page 255 and 256:
agggcatcca ctctggcatc t 21 14 36
Page 257 and 258:
99 PRT Oryctolagus cuniculus 20
Page 259 and 260:
100 105 110 Val Arg Gly Gly Ala Val
Page 261 and 262:
501 DNA Oryctolagus cuniculus 30
Page 263 and 264:
85 90 95 Leu Thr Ile Thr Asp Val Gl
Page 265 and 266:
1 5 43 16 PRT Oryctolagus cunic
Page 267 and 268:
gtctactaca tgaac 15 51 48 DNA O
Page 269 and 270:
145 150 155 160 Ala Leu Gly Cys Leu
Page 271 and 272:
gagcagctga aggagtccgg aggaggcctg gt
Page 273 and 274:
Val Val Val Lys Arg Thr Val Ala Ala
Page 275 and 276:
75 Ile Ile Gly Gly Phe Gly Thr Thr
Page 277 and 278:
Oryctolagus cuniculus 83 atcattggt
Page 279 and 280:
Page 281 and 282:
tgggcgaaag gccgattcac catctccaaa ac
Page 283 and 284:
145 150 155 160 Leu Asn Asn Phe 10
Page 285 and 286:
108 12 PRT Oryctolagus cuniculus
Page 287 and 288:
Page 289 and 290:
PRT Oryctolagus cuniculus 120 Ile
Page 291 and 292:
125 Glu Ile Ser Lys Leu Glu Ser 1 5
Page 293 and 294:
133 gaaatatcca aactggaatc t 21 134
Page 295 and 296:
100 105 110 Val Arg Ser Leu Lys Tyr
Page 297 and 298:
gcgaaaggcc gattcaccat ctccaagacc tc
Page 299 and 300:
1 5 10 15 Val Gln Cys Gln Ser Val G
Page 301 and 302:
gtcaccatca gttgccagtc cagtcagagt gt
Page 303 and 304:
50 55 60 Gly Gln Arg Pro Lys Leu Le
Page 305 and 306:
Page 307 and 308:
aattatggtg gtgatgaaag tttg 24 186
Page 309 and 310:
Page 311 and 312:
Oryctolagus cuniculus 199 agcggcta
Page 313 and 314:
Page 315 and 316:
213 21 DNA Oryctolagus cuniculus
Page 317 and 318:
65 70 75 80 Ala Lys Gly Arg Phe Thr
Page 319 and 320:
Page 321 and 322:
100 105 110 Leu Gly Ser Tyr Asp Cys
Page 323 and 324:
Ala Tyr Asp Leu 1 242 375 DNA O
Page 325 and 326:
Met Asp Thr Arg Ala Pro Thr Gln Leu
Page 327 and 328:
1 5 256 16 PRT Oryctolagus cuni
Page 329 and 330:
DNA Oryctolagus cuniculus 264 ttc
Page 331 and 332:
Trp Ala Ser Thr Leu Ala Ser 1 5 27
Page 333 and 334:
Page 335 and 336:
284 11 PRT 115 120 125 Oryctolag
Page 337 and 338:
tacgcgagtt gggcgaaagg ccgattcacc at
Page 339 and 340:
1 5 10 15 Val Gln Cys Gln Ser Val G
Page 341 and 342:
aaaccagggc agcctcccaa gctcctgatc ta
Page 343 and 344:
65 70 75 80 Gly Val Pro Ser Arg Phe
Page 345 and 346:
Page 347 and 348:
gtcattggcg atactgctgg ttatgcttat tt
Page 349 and 350:
1 5 10 < 210> 335 5 PRT Oryctola
Page 351 and 352:
Page 353 and 354:
Oryctolagus cuniculus 348 Gln Ala
Page 355 and 356:
Oryctolagus cuniculus 356 caggccag
Page 357 and 358:
Ser Thr Tyr Tyr Ile Tyr Trp Val Arg
Page 359 and 360:
gacctggagt gtgacgatgc tgccacttac ta
Page 361 and 362:
Pro Ser Arg Phe Lys Gly Ser Gly Ser
Page 363 and 364:
Page 365 and 366:
Page 367 and 368:
Page 369 and 370:
DNA Oryctolagus cuniculus 407 agc
Page 371 and 372:
1 5 10 413 7 PRT Oryctolagus cu
Page 373 and 374:
Page 375 and 376:
65 70 75 80 Ala Lys Gly Arg Phe Thr
Page 377 and 378:
atggagactg ggctgcgctg gcttctcctg gt
Page 379 and 380:
Page 381 and 382:
450 atggacacga gggcccccac tcagctgct
Page 383 and 384:
Val Ser Ala Ala Val Gly Gly Thr Val
Page 385 and 386:
Ile Ile Ala Asn Ser Gly Thr Thr Phe
Page 387 and 388:
DNA Oryctolagus cuniculus 473 gag
Page 389 and 390:
478 Gln Gln Gly Ala Thr Val Tyr Asp
Page 391 and 392:
Page 393 and 394:
492 Gln Ala Ser Glu Asn Ile Tyr Ser
Page 395 and 396:
500 caggccagtg agaacattta tagcttttt
Page 397 and 398:
50 55 60 Trp Ile Gly Ile Ile Thr Gl
Page 399 and 400:
Oryctolagus cuniculus 515 atggagac
Page 401 and 402:
523 122 PRT 115 120 Oryctolagus
Page 403 and 404:
DNA Oryctolagus cuniculus 530 atg
Page 405 and 406:
20 25 30 Val Ser Val Pro Val Gly As
Page 407 and 408:
Oryctolagus cuniculus 544 Phe Ile
Page 409 and 410:
Page 411 and 412:
Oryctolagus cuniculus 558 Gln Gln
Page 413 and 414:
Oryctolagus cuniculus 566 caacaggg
Page 415 and 416:
PRT Oryctolagus cuniculus 572 Gln
Page 417 and 418:
DNA Oryctolagus cuniculus 580 cag
Page 419 and 420:
aacaggggag agtgt 315 588 330 PRT
Page 421 and 422:
tacgtggacg gcgtggaggt gcataatgcc aa
Page 423 and 424:
15 PRT Homo sapiens 598 Asp Lys
Page 425 and 426:
Ser Lys Glu Ala Leu Ala Glu Asn Asn
Page 427 and 428:
15 PRT Homo sapiens 617 Cys Leu
Page 429 and 430:
626 Glu Gln Ala Arg Ala Val Gln Met
Page 431 and 432:
15 PRT Homo sapiens 636 Asp Pro
Page 433 and 434:
645 Leu Arg Ser Phe Lys Glu Phe Leu
Page 435 and 436:
PRT Homo sapiens 650 Asp Ile Gln
Page 437 and 438:
20 25 30 Tyr Met Ser Trp Val Arg Gl
Page 439 and 440:
65 70 75 80 Gln Met Asn Ser Leu Arg
Page 441 and 442:
Page 443 and 444:
gcaaaattta acttg 375 664 450 PRT
Page 445 and 446:
450 665 450 PRT Oryctolagus cun
Page 447 and 448:
Gly Lys 450 666 216 PRT Oryctol
Page 449 and 450:
20 25 30 Pro Gly Thr Pro Leu Thr Le
Page 451 and 452:
1 5 10 15 Val Gln Cys Gln Ser Leu G
Page 453 and 454:
676 Met Glu Thr Gly Leu Arg Trp Leu
Page 455 and 456:
PRT Oryctolagus cuniculus 680 Met
Page 457 and 458:
684 128 PRT 115 120 Oryctolagus
Page 459 and 460:
100 105 110 Gly Tyr Ser Leu Arg Asn
Page 461 and 462:
85 90 95 Arg Asp Asp Ser Ser Asp Tr
Page 463 and 464:
85 90 95 Arg Asp Asp Ser Ser Asp Tr
Page 465 and 466:
85 90 95 Ile Asp Asn Ala Phe Gly Gl
Page 467 and 468:
50 55 60 Ser Gly Ser Gly Thr Asp Ph
Page 469 and 470:
Lys Val Tyr Ala Cys Glu Val Thr His
Page 471 and 472:
195 200 205 Pro Ser Asn Thr Lys Val
Page 473 and 474:
Leu Ile Tyr Arg Ala Ser Thr Leu Ala
Page 475 and 476:
50 55 60 Trp Val Gly Ile Ile Tyr Gl
Page 477 and 478:
35 40 45 Tyr Arg Ala Ser Thr Leu Al
Page 479 and 480:
212> PRT Homo sapiens 718 Val Ile
Page 481 and 482:
ttcagcggca gtggatctgg gacagacttc ac
Page 483 and 484:
PRT Homo sapiens 726 Met Glu Lys
Page 485 and 486:
210 215 220 Thr Ala Val Ala Arg Asn
Page 487 and 488:
195 200 205 Ser Asp His Ile Asn Phe
Page 489:
690 695 700 Pro Glu Asp Leu Lys Ser
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(19) 대한민국특허청(KR) (12) 공개특허공보(A) - Questel

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