(19) 대한민국특허청(KR) (12) 공개특허공보(A) - Questel

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123 128 PRT 115 120 Oryctolagus cuniculus 123 Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 1 5 10 15 Val Gln Cys His Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 20 25 30 Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 35 40 45 Ser Arg Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 50 55 60 Trp Ile Gly Tyr Ile Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Thr Trp 65 70 75 80 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu 85 90 95 Lys Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 100 105 110 Arg Leu Gly Asp Thr Gly Gly His Ala Tyr Ala Thr Arg Leu Asn Leu 124 13 PRT 115 120 125 Oryctolagus cuniculus 124 Gln Ser Ser Gln Ser Val Gly Asn Asn Gln Asp Leu Ser 1 5 10 125 7 PRT Oryctolagus cuniculus - 290 - 공개특허 10-2011-0112308
125 Glu Ile Ser Lys Leu Glu Ser 1 5 126 11 PRT Oryctolagus cuniculus 126 Leu Gly Gly Tyr Asp Asp Asp Ala Asp Asn Ala 1 5 10 127 5 PRT Oryctolagus cuniculus 127 Ser Arg Thr Met Ser 1 5 128 16 PRT Oryctolagus cuniculus 128 Tyr Ile Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 1 5 10 15 129 15 PRT Oryctolagus cuniculus 129 Leu Gly Asp Thr Gly Gly His Ala Tyr Ala Thr Arg Leu Asn Leu 1 5 10 15 130 369 - 291 - 공개특허 10-2011-0112308
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(51) Int. Cl. (19) 대한민국특
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특허청구의 범위 청구항 1
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서열 번호: 5에 적어도 85.7%
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청구항 1 내지 20중 어느 한
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청구항 38 청구항 34에 있어
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암(Pharyngeal Cancer), 갈색세
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청구항 41에 있어서, Ab1 항
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청구항 41에 있어서, 개체
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청구항 103에 있어서, 항-IL-
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톨페남산, 톨메틴, 발데콕
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IFN-감마, BAFF, CXCL13, IP-10, VE
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드, 또는 높은 엄밀도 조건
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서열 번호: 120에 적어도 50%
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청구항 160 청구항 140 내지
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약, 항히스타민제, 아프레
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탈리주맙, 네다플라틴, 네
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[0001] [0002] [0003] [0004] [0005]
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[0015] [0016] [0017] [0018] [0019]
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[0029] [0030] [0031] [0032] [0033]
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[0040] [0041] [0042] [0043] [0044]
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[0056] [0057] [0058] [0059] [0060]
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[0084] [0085] [0086] [0087] [0088]
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[0100] [0101] [0102] [0103] [0104]
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[0132] [0133] [0134] [0135] [0136]
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[0171] [0172] [0173] [0174] [0175]
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[0186] [0187] [0188] [0189] 한 참
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[0197] [0198] [0199] [0200] [0201]
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[0210] [0211] [0212] [0213] [0214]
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[0228] [0229] [0230] [0231] [0232]
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[0242] [0243] [0244] [0245] [0246]
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[0254] [0255] [0256] [0257] [0258]
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[0276] [0277] [0278] [0279] [0280]
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[0301] [0302] [0303] [0304] [0305]
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[0363] [0364] [0365] [0366] [0367]
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[0405] [0406] [0407] [0408] [0409]
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[0411] [0412] [0413] [0414] [0415]
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[0425] [0426] [0427] [0428] [0429]
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[0438] [0439] [0440] [0441] [0442]
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[0455] [0456] [0457] [0458] [0459]
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[0463] [0464] [0465] 333, 525 415,
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[0474] [0475] [0476] [0477] [0478]
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[0495] [0496] [0497] [0498] [0499]
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[0520] [0521] [0522] [0523] [0524]
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[0537] [0538] [0539] [0540] [0541]
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[0555] [0556] [0557] [0558] [0559]
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[0588] [0589] [0590] [0591] [0592]
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[0609] [0610] [0611] [0612] [0613]
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[0623] [0624] [0625] [0626] [0627]
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[0641] [0642] [0643] [0644] [0645]
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[0664] [0665] [0666] [0667] [0668]
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[0684] [0685] challenge to evaluate
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[0686] [0687] marrow transplantatio
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[0688] prostate cancer xenografts i
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[0689] [0690] [0691] [0692] [0693]
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[0699] [0700] [0701] [0702] [0703]
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도 4에서는 인간 IL-6의 100
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[0718] [0719] [0720] [0721] [0722]
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[0737] [0738] [0739] [0740] [0741]
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[0751] [0752] [0753] [0754] [0755]
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[0771] [0772] [0773] [0774] [0775]
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[0793] [0794] [0795] [0796] [0797]
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[0815] [0816] [0817] [0818] [0819]
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[0838] [0839] [0840] [0841] [0842]
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[0868] [0869] [0870] [0871] [0872]
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[0893] [0894] [0895] [0896] [0897]
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[0917] [0918] [0919] [0920] [0921]
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[0944] [0945] [0946] [0947] [0948]
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[0976] [0977] [0978] [0979] [0980]
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[1033] [1034] [1035] [1036] [1037]
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[1091] [1092] [1093] [1094] [1095]
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[1152] [1153] [1154] [1155] [1156]
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[1210] [1211] [1212] [1213] [1214]
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[1271] [1272] [1273] [1274] [1275]
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[1331] [1332] [1333] [1334] [1335]
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[1391] [1392] [1393] [1394] [1395]
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[1452] [1453] [1454] [1455] [1456]
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[1514] [1515] [1516] [1517] [1518]
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[1575] [1576] [1577] [1578] [1579]
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[1635] [1636] [1637] [1638] [1639]
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[1695] [1696] [1697] [1698] [1699]
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[1756] [1757] [1758] [1759] [1760]
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[1817] [1818] [1819] [1820] [1821]
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[1877] [1878] [1879] [1880] [1881]
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[1937] [1938] [1939] [1940] [1941]
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[1997] [1998] [1999] [2000] [2001]
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[2059] [2060] [2061] [2062] [2063]
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[2121] [2122] [2123] [2124] [2125]
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[2177] [2178] [2179] [2180] [2181]
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[2249] [2250] [2251] [2252] [2253]
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[2302] [2303] [2304] [2305] [2306]
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[2344] [2345] [2346] [2347] [2348]
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[2378] [2379] [2380] [2381] [2382]
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[2418] [2419] [2420] [2421] 서열
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도면2 - 187 - 공개특허 10-201
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도면4 - 189 - 공개특허 10-201
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도면6 - 191 - 공개특허 10-201
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도면8 - 193 - 공개특허 10-201
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도면10a - 195 - 공개특허 10-2
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도면10c - 197 - 공개특허 10-2
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도면10e - 199 - 공개특허 10-2
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도면12 - 201 - 공개특허 10-20
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도면14 - 203 - 공개특허 10-20
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도면16 - 205 - 공개특허 10-20
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도면18 - 207 - 공개특허 10-20
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도면20 - 209 - 공개특허 10-20
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도면22 - 211 - 공개특허 10-20
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도면24 - 213 - 공개특허 10-20
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도면26a 도면26b - 215 - 공개
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도면28 - 217 - 공개특허 10-20
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도면30 도면31 - 219 - 공개특
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도면33 - 221 - 공개특허 10-20
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도면35 - 223 - 공개특허 10-20
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도면36b - 225 - 공개특허 10-2
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도면37b - 227 - 공개특허 10-2
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도면39 - 229 - 공개특허 10-20
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도면41 - 231 - 공개특허 10-20
Page 233 and 234:
도면43 - 233 - 공개특허 10-20
Page 235 and 236:
도면45 - 235 - 공개특허 10-20
Page 237 and 238:
도면47 - 237 - 공개특허 10-20
Page 239 and 240: 도면49 - 239 - 공개특허 10-20
Page 241 and 242: 도면51 - 241 - 공개특허 10-20
Page 243 and 244: 도면53 - 243 - 공개특허 10-20
Page 245 and 246: 도면56 도면57 - 245 - 공개특
Page 247 and 248: 도면60 도면61 - 247 - 공개특
Page 249 and 250: Smith, Jeffrey T.L. Schatzman, Rand
Page 251 and 252: Leu Pro Gly Ala Arg Cys Ala Tyr Asp
Page 253 and 254: PRT Oryctolagus cuniculus 6 Gln G
Page 255 and 256: agggcatcca ctctggcatc t 21 14 36
Page 257 and 258: 99 PRT Oryctolagus cuniculus 20
Page 259 and 260: 100 105 110 Val Arg Gly Gly Ala Val
Page 261 and 262: 501 DNA Oryctolagus cuniculus 30
Page 263 and 264: 85 90 95 Leu Thr Ile Thr Asp Val Gl
Page 265 and 266: 1 5 43 16 PRT Oryctolagus cunic
Page 267 and 268: gtctactaca tgaac 15 51 48 DNA O
Page 269 and 270: 145 150 155 160 Ala Leu Gly Cys Leu
Page 271 and 272: gagcagctga aggagtccgg aggaggcctg gt
Page 273 and 274: Val Val Val Lys Arg Thr Val Ala Ala
Page 275 and 276: 75 Ile Ile Gly Gly Phe Gly Thr Thr
Page 277 and 278: Oryctolagus cuniculus 83 atcattggt
Page 281 and 282: tgggcgaaag gccgattcac catctccaaa ac
Page 283 and 284: 145 150 155 160 Leu Asn Asn Phe 10
Page 285 and 286: 108 12 PRT Oryctolagus cuniculus
Page 289: PRT Oryctolagus cuniculus 120 Ile
Page 293 and 294: 133 gaaatatcca aactggaatc t 21 134
Page 295 and 296: 100 105 110 Val Arg Ser Leu Lys Tyr
Page 297 and 298: gcgaaaggcc gattcaccat ctccaagacc tc
Page 299 and 300: 1 5 10 15 Val Gln Cys Gln Ser Val G
Page 301 and 302: gtcaccatca gttgccagtc cagtcagagt gt
Page 303 and 304: 50 55 60 Gly Gln Arg Pro Lys Leu Le
Page 307 and 308: aattatggtg gtgatgaaag tttg 24 186
Page 311 and 312: Oryctolagus cuniculus 199 agcggcta
Page 315 and 316: 213 21 DNA Oryctolagus cuniculus
Page 317 and 318: 65 70 75 80 Ala Lys Gly Arg Phe Thr
Page 321 and 322: 100 105 110 Leu Gly Ser Tyr Asp Cys
Page 323 and 324: Ala Tyr Asp Leu 1 242 375 DNA O
Page 325 and 326: Met Asp Thr Arg Ala Pro Thr Gln Leu
Page 327 and 328: 1 5 256 16 PRT Oryctolagus cuni
Page 329 and 330: DNA Oryctolagus cuniculus 264 ttc
Page 331 and 332: Trp Ala Ser Thr Leu Ala Ser 1 5 27
Page 333 and 334: 278 33 DNA Oryctolagus cuniculus
Page 335 and 336: 284 11 PRT 115 120 125 Oryctolag
Page 337 and 338: tacgcgagtt gggcgaaagg ccgattcacc at
Page 339 and 340: 1 5 10 15 Val Gln Cys Gln Ser Val G
Page 341 and 342:
aaaccagggc agcctcccaa gctcctgatc ta
Page 343 and 344:
65 70 75 80 Gly Val Pro Ser Arg Phe
Page 345 and 346:
321 16 PRT Oryctolagus cuniculus
Page 347 and 348:
gtcattggcg atactgctgg ttatgcttat tt
Page 349 and 350:
1 5 10 < 210> 335 5 PRT Oryctola
Page 351 and 352:
343 15 DNA Oryctolagus cuniculus
Page 353 and 354:
Oryctolagus cuniculus 348 Gln Ala
Page 355 and 356:
Oryctolagus cuniculus 356 caggccag
Page 357 and 358:
Ser Thr Tyr Tyr Ile Tyr Trp Val Arg
Page 359 and 360:
gacctggagt gtgacgatgc tgccacttac ta
Page 361 and 362:
Pro Ser Arg Phe Lys Gly Ser Gly Ser
Page 363 and 364:
10 PRT Oryctolagus cuniculus 385
Page 365 and 366:
Page 367 and 368:
Page 369 and 370:
DNA Oryctolagus cuniculus 407 agc
Page 371 and 372:
1 5 10 413 7 PRT Oryctolagus cu
Page 373 and 374:
Page 375 and 376:
65 70 75 80 Ala Lys Gly Arg Phe Thr
Page 377 and 378:
atggagactg ggctgcgctg gcttctcctg gt
Page 379 and 380:
Page 381 and 382:
450 atggacacga gggcccccac tcagctgct
Page 383 and 384:
Val Ser Ala Ala Val Gly Gly Thr Val
Page 385 and 386:
Ile Ile Ala Asn Ser Gly Thr Thr Phe
Page 387 and 388:
DNA Oryctolagus cuniculus 473 gag
Page 389 and 390:
478 Gln Gln Gly Ala Thr Val Tyr Asp
Page 391 and 392:
Page 393 and 394:
492 Gln Ala Ser Glu Asn Ile Tyr Ser
Page 395 and 396:
500 caggccagtg agaacattta tagcttttt
Page 397 and 398:
50 55 60 Trp Ile Gly Ile Ile Thr Gl
Page 399 and 400:
Oryctolagus cuniculus 515 atggagac
Page 401 and 402:
523 122 PRT 115 120 Oryctolagus
Page 403 and 404:
DNA Oryctolagus cuniculus 530 atg
Page 405 and 406:
20 25 30 Val Ser Val Pro Val Gly As
Page 407 and 408:
Oryctolagus cuniculus 544 Phe Ile
Page 409 and 410:
Page 411 and 412:
Oryctolagus cuniculus 558 Gln Gln
Page 413 and 414:
Oryctolagus cuniculus 566 caacaggg
Page 415 and 416:
PRT Oryctolagus cuniculus 572 Gln
Page 417 and 418:
DNA Oryctolagus cuniculus 580 cag
Page 419 and 420:
aacaggggag agtgt 315 588 330 PRT
Page 421 and 422:
tacgtggacg gcgtggaggt gcataatgcc aa
Page 423 and 424:
15 PRT Homo sapiens 598 Asp Lys
Page 425 and 426:
Ser Lys Glu Ala Leu Ala Glu Asn Asn
Page 427 and 428:
15 PRT Homo sapiens 617 Cys Leu
Page 429 and 430:
626 Glu Gln Ala Arg Ala Val Gln Met
Page 431 and 432:
15 PRT Homo sapiens 636 Asp Pro
Page 433 and 434:
645 Leu Arg Ser Phe Lys Glu Phe Leu
Page 435 and 436:
PRT Homo sapiens 650 Asp Ile Gln
Page 437 and 438:
20 25 30 Tyr Met Ser Trp Val Arg Gl
Page 439 and 440:
65 70 75 80 Gln Met Asn Ser Leu Arg
Page 441 and 442:
Page 443 and 444:
gcaaaattta acttg 375 664 450 PRT
Page 445 and 446:
450 665 450 PRT Oryctolagus cun
Page 447 and 448:
Gly Lys 450 666 216 PRT Oryctol
Page 449 and 450:
20 25 30 Pro Gly Thr Pro Leu Thr Le
Page 451 and 452:
1 5 10 15 Val Gln Cys Gln Ser Leu G
Page 453 and 454:
676 Met Glu Thr Gly Leu Arg Trp Leu
Page 455 and 456:
PRT Oryctolagus cuniculus 680 Met
Page 457 and 458:
684 128 PRT 115 120 Oryctolagus
Page 459 and 460:
100 105 110 Gly Tyr Ser Leu Arg Asn
Page 461 and 462:
85 90 95 Arg Asp Asp Ser Ser Asp Tr
Page 463 and 464:
85 90 95 Arg Asp Asp Ser Ser Asp Tr
Page 465 and 466:
85 90 95 Ile Asp Asn Ala Phe Gly Gl
Page 467 and 468:
50 55 60 Ser Gly Ser Gly Thr Asp Ph
Page 469 and 470:
Lys Val Tyr Ala Cys Glu Val Thr His
Page 471 and 472:
195 200 205 Pro Ser Asn Thr Lys Val
Page 473 and 474:
Leu Ile Tyr Arg Ala Ser Thr Leu Ala
Page 475 and 476:
50 55 60 Trp Val Gly Ile Ile Tyr Gl
Page 477 and 478:
35 40 45 Tyr Arg Ala Ser Thr Leu Al
Page 479 and 480:
212> PRT Homo sapiens 718 Val Ile
Page 481 and 482:
ttcagcggca gtggatctgg gacagacttc ac
Page 483 and 484:
PRT Homo sapiens 726 Met Glu Lys
Page 485 and 486:
210 215 220 Thr Ala Val Ala Arg Asn
Page 487 and 488:
195 200 205 Ser Asp His Ile Asn Phe
Page 489:
690 695 700 Pro Glu Asp Leu Lys Ser
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(19) 대한민국특허청(KR) (12) 공개특허공보(A) - Questel

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