(19) 대한민국특허청(KR) (12) 공개특허공보(A) - Questel

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accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc 600 catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t 651 702 217 PRT Oryctolagus cuniculus 702 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Leu Arg Asn 85 90 95 Ile Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 - 468 - 공개특허 10-2011-0112308
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 703 1350 DNA Oryctolagus cuniculus 703 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt ctccctcagt aactactacg tgacctgggt ccgtcaggct 120 ccagggaagg ggctggagtg ggtcggcatc atctatggta gtgatgaaac cgcctacgct 180 acctccgcta taggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt 240 caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agatgatagt 300 agtgactggg atgcaaagtt caacttgtgg ggccaaggga ccctcgtcac cgtctcgagc 360 gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 420 ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 480 tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 540 ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 600 tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc 660 aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga 720 ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 780 gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 840 tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc 900 agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 960 gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 1020 aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag 1080 atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 1140 gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 1200 ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg 1260 cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 1320 - 469 - 공개특허 10-2011-0112308
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(51) Int. Cl. (19) 대한민국특
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특허청구의 범위 청구항 1
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서열 번호: 5에 적어도 85.7%
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청구항 1 내지 20중 어느 한
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청구항 38 청구항 34에 있어
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암(Pharyngeal Cancer), 갈색세
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청구항 41에 있어서, Ab1 항
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청구항 41에 있어서, 개체
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청구항 103에 있어서, 항-IL-
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톨페남산, 톨메틴, 발데콕
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IFN-감마, BAFF, CXCL13, IP-10, VE
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드, 또는 높은 엄밀도 조건
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서열 번호: 120에 적어도 50%
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청구항 160 청구항 140 내지
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약, 항히스타민제, 아프레
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탈리주맙, 네다플라틴, 네
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[0001] [0002] [0003] [0004] [0005]
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[0015] [0016] [0017] [0018] [0019]
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[0029] [0030] [0031] [0032] [0033]
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[0040] [0041] [0042] [0043] [0044]
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[0056] [0057] [0058] [0059] [0060]
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[0084] [0085] [0086] [0087] [0088]
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[0100] [0101] [0102] [0103] [0104]
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[0132] [0133] [0134] [0135] [0136]
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[0171] [0172] [0173] [0174] [0175]
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[0186] [0187] [0188] [0189] 한 참
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[0197] [0198] [0199] [0200] [0201]
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[0210] [0211] [0212] [0213] [0214]
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[0228] [0229] [0230] [0231] [0232]
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[0242] [0243] [0244] [0245] [0246]
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[0254] [0255] [0256] [0257] [0258]
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[0276] [0277] [0278] [0279] [0280]
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[0301] [0302] [0303] [0304] [0305]
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[0363] [0364] [0365] [0366] [0367]
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[0405] [0406] [0407] [0408] [0409]
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[0411] [0412] [0413] [0414] [0415]
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[0425] [0426] [0427] [0428] [0429]
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[0438] [0439] [0440] [0441] [0442]
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[0455] [0456] [0457] [0458] [0459]
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[0463] [0464] [0465] 333, 525 415,
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[0474] [0475] [0476] [0477] [0478]
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[0495] [0496] [0497] [0498] [0499]
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[0520] [0521] [0522] [0523] [0524]
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[0537] [0538] [0539] [0540] [0541]
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[0555] [0556] [0557] [0558] [0559]
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[0588] [0589] [0590] [0591] [0592]
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[0609] [0610] [0611] [0612] [0613]
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[0623] [0624] [0625] [0626] [0627]
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[0641] [0642] [0643] [0644] [0645]
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[0664] [0665] [0666] [0667] [0668]
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[0684] [0685] challenge to evaluate
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[0686] [0687] marrow transplantatio
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[0688] prostate cancer xenografts i
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[0689] [0690] [0691] [0692] [0693]
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[0699] [0700] [0701] [0702] [0703]
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도 4에서는 인간 IL-6의 100
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[0718] [0719] [0720] [0721] [0722]
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[0737] [0738] [0739] [0740] [0741]
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[0751] [0752] [0753] [0754] [0755]
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[0771] [0772] [0773] [0774] [0775]
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[0793] [0794] [0795] [0796] [0797]
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[0815] [0816] [0817] [0818] [0819]
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[0838] [0839] [0840] [0841] [0842]
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[0868] [0869] [0870] [0871] [0872]
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[0893] [0894] [0895] [0896] [0897]
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[0917] [0918] [0919] [0920] [0921]
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[0944] [0945] [0946] [0947] [0948]
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[0976] [0977] [0978] [0979] [0980]
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[1033] [1034] [1035] [1036] [1037]
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[1091] [1092] [1093] [1094] [1095]
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[1152] [1153] [1154] [1155] [1156]
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[1210] [1211] [1212] [1213] [1214]
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[1271] [1272] [1273] [1274] [1275]
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[1331] [1332] [1333] [1334] [1335]
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[1391] [1392] [1393] [1394] [1395]
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[1452] [1453] [1454] [1455] [1456]
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[1575] [1576] [1577] [1578] [1579]
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[1635] [1636] [1637] [1638] [1639]
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[1756] [1757] [1758] [1759] [1760]
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[1817] [1818] [1819] [1820] [1821]
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[1877] [1878] [1879] [1880] [1881]
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[1937] [1938] [1939] [1940] [1941]
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[1997] [1998] [1999] [2000] [2001]
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[2059] [2060] [2061] [2062] [2063]
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[2121] [2122] [2123] [2124] [2125]
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[2177] [2178] [2179] [2180] [2181]
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[2249] [2250] [2251] [2252] [2253]
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[2302] [2303] [2304] [2305] [2306]
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[2344] [2345] [2346] [2347] [2348]
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[2378] [2379] [2380] [2381] [2382]
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[2418] [2419] [2420] [2421] 서열
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도면2 - 187 - 공개특허 10-201
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도면4 - 189 - 공개특허 10-201
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도면6 - 191 - 공개특허 10-201
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도면8 - 193 - 공개특허 10-201
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도면10a - 195 - 공개특허 10-2
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도면10c - 197 - 공개특허 10-2
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도면10e - 199 - 공개특허 10-2
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도면12 - 201 - 공개특허 10-20
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도면14 - 203 - 공개특허 10-20
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도면16 - 205 - 공개특허 10-20
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도면18 - 207 - 공개특허 10-20
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도면20 - 209 - 공개특허 10-20
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도면22 - 211 - 공개특허 10-20
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도면24 - 213 - 공개특허 10-20
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도면26a 도면26b - 215 - 공개
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도면28 - 217 - 공개특허 10-20
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도면30 도면31 - 219 - 공개특
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도면33 - 221 - 공개특허 10-20
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도면35 - 223 - 공개특허 10-20
Page 225 and 226:
도면36b - 225 - 공개특허 10-2
Page 227 and 228:
도면37b - 227 - 공개특허 10-2
Page 229 and 230:
도면39 - 229 - 공개특허 10-20
Page 231 and 232:
도면41 - 231 - 공개특허 10-20
Page 233 and 234:
도면43 - 233 - 공개특허 10-20
Page 235 and 236:
도면45 - 235 - 공개특허 10-20
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도면47 - 237 - 공개특허 10-20
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도면49 - 239 - 공개특허 10-20
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도면51 - 241 - 공개특허 10-20
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도면53 - 243 - 공개특허 10-20
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도면56 도면57 - 245 - 공개특
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도면60 도면61 - 247 - 공개특
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Smith, Jeffrey T.L. Schatzman, Rand
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Leu Pro Gly Ala Arg Cys Ala Tyr Asp
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PRT Oryctolagus cuniculus 6 Gln G
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agggcatcca ctctggcatc t 21 14 36
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99 PRT Oryctolagus cuniculus 20
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100 105 110 Val Arg Gly Gly Ala Val
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501 DNA Oryctolagus cuniculus 30
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85 90 95 Leu Thr Ile Thr Asp Val Gl
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1 5 43 16 PRT Oryctolagus cunic
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gtctactaca tgaac 15 51 48 DNA O
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145 150 155 160 Ala Leu Gly Cys Leu
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gagcagctga aggagtccgg aggaggcctg gt
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Val Val Val Lys Arg Thr Val Ala Ala
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75 Ile Ile Gly Gly Phe Gly Thr Thr
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Oryctolagus cuniculus 83 atcattggt
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tgggcgaaag gccgattcac catctccaaa ac
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145 150 155 160 Leu Asn Asn Phe 10
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108 12 PRT Oryctolagus cuniculus
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PRT Oryctolagus cuniculus 120 Ile
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125 Glu Ile Ser Lys Leu Glu Ser 1 5
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133 gaaatatcca aactggaatc t 21 134
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100 105 110 Val Arg Ser Leu Lys Tyr
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gcgaaaggcc gattcaccat ctccaagacc tc
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1 5 10 15 Val Gln Cys Gln Ser Val G
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gtcaccatca gttgccagtc cagtcagagt gt
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50 55 60 Gly Gln Arg Pro Lys Leu Le
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aattatggtg gtgatgaaag tttg 24 186
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Oryctolagus cuniculus 199 agcggcta
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213 21 DNA Oryctolagus cuniculus
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65 70 75 80 Ala Lys Gly Arg Phe Thr
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Page 321 and 322:
100 105 110 Leu Gly Ser Tyr Asp Cys
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Ala Tyr Asp Leu 1 242 375 DNA O
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Met Asp Thr Arg Ala Pro Thr Gln Leu
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1 5 256 16 PRT Oryctolagus cuni
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DNA Oryctolagus cuniculus 264 ttc
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Trp Ala Ser Thr Leu Ala Ser 1 5 27
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284 11 PRT 115 120 125 Oryctolag
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tacgcgagtt gggcgaaagg ccgattcacc at
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1 5 10 15 Val Gln Cys Gln Ser Val G
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aaaccagggc agcctcccaa gctcctgatc ta
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65 70 75 80 Gly Val Pro Ser Arg Phe
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gtcattggcg atactgctgg ttatgcttat tt
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1 5 10 < 210> 335 5 PRT Oryctola
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Oryctolagus cuniculus 348 Gln Ala
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Oryctolagus cuniculus 356 caggccag
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Ser Thr Tyr Tyr Ile Tyr Trp Val Arg
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gacctggagt gtgacgatgc tgccacttac ta
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Pro Ser Arg Phe Lys Gly Ser Gly Ser
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DNA Oryctolagus cuniculus 407 agc
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1 5 10 413 7 PRT Oryctolagus cu
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65 70 75 80 Ala Lys Gly Arg Phe Thr
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atggagactg ggctgcgctg gcttctcctg gt
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450 atggacacga gggcccccac tcagctgct
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Val Ser Ala Ala Val Gly Gly Thr Val
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Ile Ile Ala Asn Ser Gly Thr Thr Phe
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DNA Oryctolagus cuniculus 473 gag
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478 Gln Gln Gly Ala Thr Val Tyr Asp
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492 Gln Ala Ser Glu Asn Ile Tyr Ser
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500 caggccagtg agaacattta tagcttttt
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50 55 60 Trp Ile Gly Ile Ile Thr Gl
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Oryctolagus cuniculus 515 atggagac
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523 122 PRT 115 120 Oryctolagus
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DNA Oryctolagus cuniculus 530 atg
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20 25 30 Val Ser Val Pro Val Gly As
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Oryctolagus cuniculus 544 Phe Ile
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Oryctolagus cuniculus 558 Gln Gln
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Oryctolagus cuniculus 566 caacaggg
Page 415 and 416:
PRT Oryctolagus cuniculus 572 Gln
Page 417 and 418: DNA Oryctolagus cuniculus 580 cag
Page 419 and 420: aacaggggag agtgt 315 588 330 PRT
Page 421 and 422: tacgtggacg gcgtggaggt gcataatgcc aa
Page 423 and 424: 15 PRT Homo sapiens 598 Asp Lys
Page 425 and 426: Ser Lys Glu Ala Leu Ala Glu Asn Asn
Page 427 and 428: 15 PRT Homo sapiens 617 Cys Leu
Page 429 and 430: 626 Glu Gln Ala Arg Ala Val Gln Met
Page 431 and 432: 15 PRT Homo sapiens 636 Asp Pro
Page 433 and 434: 645 Leu Arg Ser Phe Lys Glu Phe Leu
Page 435 and 436: PRT Homo sapiens 650 Asp Ile Gln
Page 437 and 438: 20 25 30 Tyr Met Ser Trp Val Arg Gl
Page 439 and 440: 65 70 75 80 Gln Met Asn Ser Leu Arg
Page 441 and 442: 122 PRT Oryctolagus cuniculus 66
Page 443 and 444: gcaaaattta acttg 375 664 450 PRT
Page 445 and 446: 450 665 450 PRT Oryctolagus cun
Page 447 and 448: Gly Lys 450 666 216 PRT Oryctol
Page 449 and 450: 20 25 30 Pro Gly Thr Pro Leu Thr Le
Page 451 and 452: 1 5 10 15 Val Gln Cys Gln Ser Leu G
Page 453 and 454: 676 Met Glu Thr Gly Leu Arg Trp Leu
Page 455 and 456: PRT Oryctolagus cuniculus 680 Met
Page 457 and 458: 684 128 PRT 115 120 Oryctolagus
Page 459 and 460: 100 105 110 Gly Tyr Ser Leu Arg Asn
Page 461 and 462: 85 90 95 Arg Asp Asp Ser Ser Asp Tr
Page 463 and 464: 85 90 95 Arg Asp Asp Ser Ser Asp Tr
Page 465 and 466: 85 90 95 Ile Asp Asn Ala Phe Gly Gl
Page 467: 50 55 60 Ser Gly Ser Gly Thr Asp Ph
Page 471 and 472: 195 200 205 Pro Ser Asn Thr Lys Val
Page 473 and 474: Leu Ile Tyr Arg Ala Ser Thr Leu Ala
Page 475 and 476: 50 55 60 Trp Val Gly Ile Ile Tyr Gl
Page 477 and 478: 35 40 45 Tyr Arg Ala Ser Thr Leu Al
Page 479 and 480: 212> PRT Homo sapiens 718 Val Ile
Page 481 and 482: ttcagcggca gtggatctgg gacagacttc ac
Page 483 and 484: PRT Homo sapiens 726 Met Glu Lys
Page 485 and 486: 210 215 220 Thr Ala Val Ala Arg Asn
Page 487 and 488: 195 200 205 Ser Asp His Ile Asn Phe
Page 489: 690 695 700 Pro Glu Asp Leu Lys Ser
show all

(19) 대한민국특허청(KR) (12) 공개특허공보(A) - Questel

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