(19) 대한민국특허청(KR) (12) 공개특허공보(A) - Questel

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[1725] [1726] [1727] [1728] [1729] [1730] [1731] [1732] [1733] [1734] [1735] [1736] [1737] [1738] [1739] [1740] [1741] [1742] [1743] [1744] [1745] [1746] [1747] [1748] [1749] [1750] [1751] [1752] [1753] [1754] [1755] QASQSISSYLA 서열 번호: 381 RASTLAS 서열 번호: 382 QSYYDSVSNP 서열 번호: 383 TYWFMC 서열 번호: 384 CIYTGSSGSTFYASWVNG 서열 번호: 385 GYSGYGYFKL 서열 번호: 386 ATGGACACGAGGGCCCCCACTCAGCTGCTGGGGCTCCTGCTGCTCTGGCTCCCAGGTGCCAGATGTGCATTCGAATTGACCCAGACTCCATCCTCCGTGGAG GCAGCTGTGGGAGGCACAGTCACCATCAAGTGCCAGGCCAGTCAGAGCATTAGTAGTTACTTAGCCTGGTATCAGCAGAAACCAGGGCAGCCTCCCAAGTTC CTGATCTACAGGGCGTCCACTCTGGCATCTGGGGTCCCATCGCGATTCAAAGGCAGTGGATCTGGGACAGAGTTCACTCTCACCATCAGCGACCTGGAGTGT GCCGATGCTGCCACTTACTACTGTCAAAGCTATTATGATAGTGTTTCAAATCCT 서열 번호: 387 ATGGAGACTGGGCTGCGCTGGCTTCTCCTGGTCGCTGTGCTCAAAGGTGTCCAGTGTCAGTCGTTGGAGGAGTCCGGGGGAGACCTGGTCAAGCCTGAGGGA TCCCTGACACTCACCTGCAAAGCCTCTGGACTCGACCTCGGTACCTACTGGTTCATGTGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGCT TGTATTTATACTGGTAGTAGTGGTTCCACTTTCTACGCGAGCTGGGTGAATGGCCGATTCACCATCTCCAAAACCTCGTCGACCACGGTGACTCTGCAAATG ACCAGTCTGACAGCCGCGGACACGGCCACTTATTTTTGTGCGAGAGGTTATAGTGGTTATGGTTATTTTAAGTTG 서열 번호: 388 CAGGCCAGTCAGAGCATTAGTAGTTACTTAGCC 서열 번호: 389 AGGGCGTCCACTCTGGCATCT 서열 번호: 390 CAAAGCTATTATGATAGTGTTTCAAATCCT 서열 번호: 391 ACCTACTGGTTCATGTGC 서열 번호: 392 TGTATTTATACTGGTAGTAGTGGTTCCACTTTCTACGCGAGCTGGGTGAATGGC 서열 번호: 393 GGTTATAGTGGTTATGGTTATTTTAAGTTG 서열 번호: 394 MDTRAPTQLLGLLLLWLPGVTFAIEMTQSPFSVSAAVGGTVSISCQASQSVYKNNQLSWYQQKSGQPPKLLIYGASALASGVPSRFKGSGSGTEFTLTISDV QCDDAATYYCAGAITGSIDTDG 서열 번호: 395 공개특허 10-2011-01<strong>12</strong>308 METGLRWLLLVAVLKGVQCQSLEESGGDLVKPGASLTLTCTTSGFSFSSSYFICWVRQAPGKGLEWIACIYGGDGSTYYASWAKGRFTISKTSSTTVTLQMT - 160 -
[1756] [1757] [1758] [1759] [1760] [1761] [1762] [1763] [1764] [1765] [1766] [1767] [1768] [1769] [1770] [1771] [1772] [1773] [1774] [1775] [1776] [1777] [1778] [1779] [1780] [1781] [1782] [1783] [1784] [1785] SLTAADTATYFCAREWAYSQGYFGAFDL 서열 번호: 396 QASQSVYKNNQLS 서열 번호: 397 GASALAS 서열 번호: 398 AGAITGSIDTDG 서열 번호: 399 SSYFIC 서열 번호: 400 CIYGGDGSTYYASWAKG 서열 번호: 401 EWAYSQGYFGAFDL 서열 번호: 402 ATGGACACGAGGGCCCCCACTCAGCTGCTGGGGCTCCTGCTGCTCTGGCTCCCAGGTGTCACATTTGCCATCGAAATGACCCAGAGTCCATTCTCCGTGTCT GCAGCTGTGGGAGGCACAGTCAGCATCAGTTGCCAGGCCAGTCAGAGTGTTTATAAGAACAACCAATTATCCTGGTATCAGCAGAAATCAGGGCAGCCTCCC AAGCTCCTGATCTATGGTGCATCGGCTCTGGCATCTGGGGTCCCATCGCGGTTCAAAGGCAGTGGATCTGGGACAGAGTTCACTCTCACCATCAGCGACGTG CAGTGTGACGATGCTGCCACTTACTACTGTGCAGGCGCTATTACTGGTAGTATTGATACGGATGGT 서열 번호: 403 ATGGAGACTGGGCTGCGCTGGCTTCTCCTGGTCGCTGTGCTCAAAGGTGTCCAGTGTCAGTCGTTGGAGGAGTCCGGGGGAGACCTGGTCAAGCCTGGGGCA TCCCTGACACTCACCTGCACAACTTCTGGATTCTCCTTCAGTAGCAGCTACTTCATTTGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGCA TGCATTTATGGTGGTGATGGCAGCACATACTACGCGAGCTGGGCGAAAGGCCGATTCACCATCTCCAAAACCTCGTCGACCACGGTGACGCTGCAAATGACC AGTCTGACAGCCGCGGACACGGCCACCTATTTCTGTGCGAGAGAATGGGCATATAGTCAAGGTTATTTTGGTGCTTTTGATCTC 서열 번호: 404 CAGGCCAGTCAGAGTGTTTATAAGAACAACCAATTATCC 서열 번호: 405 GGTGCATCGGCTCTGGCATCT 서열 번호: 406 GCAGGCGCTATTACTGGTAGTATTGATACGGATGGT 서열 번호: 407 AGCAGCTACTTCATTTGC 서열 번호: 408 TGCATTTATGGTGGTGATGGCAGCACATACTACGCGAGCTGGGCGAAAGGC 서열 번호: 409 GAATGGGCATATAGTCAAGGTTATTTTGGTGCTTTTGATCTC 서열 번호: 410 MDTRAPTQLLGLLLLWLPGARCDVVMTQTPASVEAAVGGTVTIKCQASEDISSYLAWYQQKPGQPPKLLIYAASNLESGVSSRFKGSGSGTEYTLTISDLEC ADAATYYCQCTYGTISISDGNA - 161 - 공개특허 10-2011-01<strong>12</strong>308
Page 1 and 2:
(51) Int. Cl. (19) 대한민국특
Page 3 and 4:
특허청구의 범위 청구항 1
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서열 번호: 5에 적어도 85.7%
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청구항 1 내지 20중 어느 한
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청구항 38 청구항 34에 있어
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암(Pharyngeal Cancer), 갈색세
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청구항 41에 있어서, Ab1 항
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청구항 41에 있어서, 개체
Page 17 and 18:
청구항 103에 있어서, 항-IL-
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톨페남산, 톨메틴, 발데콕
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IFN-감마, BAFF, CXCL13, IP-10, VE
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드, 또는 높은 엄밀도 조건
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서열 번호: 120에 적어도 50%
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청구항 160 청구항 140 내지
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약, 항히스타민제, 아프레
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탈리주맙, 네다플라틴, 네
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[0001] [0002] [0003] [0004] [0005]
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[0015] [0016] [0017] [0018] [0019]
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[0029] [0030] [0031] [0032] [0033]
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[0040] [0041] [0042] [0043] [0044]
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[0056] [0057] [0058] [0059] [0060]
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[0084] [0085] [0086] [0087] [0088]
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[0100] [0101] [0102] [0103] [0104]
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[0132] [0133] [0134] [0135] [0136]
Page 49 and 50:
[0171] [0172] [0173] [0174] [0175]
Page 51 and 52:
[0186] [0187] [0188] [0189] 한 참
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[0197] [0198] [0199] [0200] [0201]
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[0210] [0211] [0212] [0213] [0214]
Page 57 and 58:
[0228] [0229] [0230] [0231] [0232]
Page 59 and 60:
[0242] [0243] [0244] [0245] [0246]
Page 61 and 62:
[0254] [0255] [0256] [0257] [0258]
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[0276] [0277] [0278] [0279] [0280]
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[0301] [0302] [0303] [0304] [0305]
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[0363] [0364] [0365] [0366] [0367]
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[0405] [0406] [0407] [0408] [0409]
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[0411] [0412] [0413] [0414] [0415]
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[0425] [0426] [0427] [0428] [0429]
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[0438] [0439] [0440] [0441] [0442]
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[0455] [0456] [0457] [0458] [0459]
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[0463] [0464] [0465] 333, 525 415,
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[0474] [0475] [0476] [0477] [0478]
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[0495] [0496] [0497] [0498] [0499]
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[0520] [0521] [0522] [0523] [0524]
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[0537] [0538] [0539] [0540] [0541]
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[0555] [0556] [0557] [0558] [0559]
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[0588] [0589] [0590] [0591] [0592]
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[0609] [0610] [0611] [0612] [0613]
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[0623] [0624] [0625] [0626] [0627]
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[0641] [0642] [0643] [0644] [0645]
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[0664] [0665] [0666] [0667] [0668]
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[0684] [0685] challenge to evaluate
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[0686] [0687] marrow transplantatio
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[0688] prostate cancer xenografts i
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[0689] [0690] [0691] [0692] [0693]
Page 109 and 110: [0699] [0700] [0701] [0702] [0703]
Page 111 and 112: 도 4에서는 인간 IL-6의 100
Page 113 and 114: [0718] [0719] [0720] [0721] [0722]
Page 115 and 116: [0737] [0738] [0739] [0740] [0741]
Page 117 and 118: [0751] [0752] [0753] [0754] [0755]
Page 119 and 120: [0771] [0772] [0773] [0774] [0775]
Page 121 and 122: [0793] [0794] [0795] [0796] [0797]
Page 123 and 124: [0815] [0816] [0817] [0818] [0819]
Page 125 and 126: [0838] [0839] [0840] [0841] [0842]
Page 127 and 128: [0868] [0869] [0870] [0871] [0872]
Page 129 and 130: [0893] [0894] [0895] [0896] [0897]
Page 131 and 132: [0917] [0918] [0919] [0920] [0921]
Page 133 and 134: [0944] [0945] [0946] [0947] [0948]
Page 135 and 136: [0976] [0977] [0978] [0979] [0980]
Page 137 and 138: [1033] [1034] [1035] [1036] [1037]
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Page 143 and 144: [1210] [1211] [1212] [1213] [1214]
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Page 147 and 148: [1331] [1332] [1333] [1334] [1335]
Page 149 and 150: [1391] [1392] [1393] [1394] [1395]
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Page 153 and 154: [1514] [1515] [1516] [1517] [1518]
Page 155 and 156: [1575] [1576] [1577] [1578] [1579]
Page 157 and 158: [1635] [1636] [1637] [1638] [1639]
Page 159: [1695] [1696] [1697] [1698] [1699]
Page 163 and 164: [1817] [1818] [1819] [1820] [1821]
Page 165 and 166: [1877] [1878] [1879] [1880] [1881]
Page 167 and 168: [1937] [1938] [1939] [1940] [1941]
Page 169 and 170: [1997] [1998] [1999] [2000] [2001]
Page 171 and 172: [2059] [2060] [2061] [2062] [2063]
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Page 183 and 184: [2378] [2379] [2380] [2381] [2382]
Page 185 and 186: [2418] [2419] [2420] [2421] 서열
Page 187 and 188: 도면2 - 187 - 공개특허 10-201
Page 189 and 190: 도면4 - 189 - 공개특허 10-201
Page 191 and 192: 도면6 - 191 - 공개특허 10-201
Page 193 and 194: 도면8 - 193 - 공개특허 10-201
Page 195 and 196: 도면10a - 195 - 공개특허 10-2
Page 197 and 198: 도면10c - 197 - 공개특허 10-2
Page 199 and 200: 도면10e - 199 - 공개특허 10-2
Page 201 and 202: 도면12 - 201 - 공개특허 10-20
Page 203 and 204: 도면14 - 203 - 공개특허 10-20
Page 205 and 206: 도면16 - 205 - 공개특허 10-20
Page 207 and 208: 도면18 - 207 - 공개특허 10-20
Page 209 and 210: 도면20 - 209 - 공개특허 10-20
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도면22 - 211 - 공개특허 10-20
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도면24 - 213 - 공개특허 10-20
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도면26a 도면26b - 215 - 공개
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도면28 - 217 - 공개특허 10-20
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도면30 도면31 - 219 - 공개특
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도면33 - 221 - 공개특허 10-20
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도면35 - 223 - 공개특허 10-20
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도면36b - 225 - 공개특허 10-2
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도면37b - 227 - 공개특허 10-2
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도면39 - 229 - 공개특허 10-20
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도면41 - 231 - 공개특허 10-20
Page 233 and 234:
도면43 - 233 - 공개특허 10-20
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도면45 - 235 - 공개특허 10-20
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도면47 - 237 - 공개특허 10-20
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도면49 - 239 - 공개특허 10-20
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도면51 - 241 - 공개특허 10-20
Page 243 and 244:
도면53 - 243 - 공개특허 10-20
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도면56 도면57 - 245 - 공개특
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도면60 도면61 - 247 - 공개특
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Smith, Jeffrey T.L. Schatzman, Rand
Page 251 and 252:
Leu Pro Gly Ala Arg Cys Ala Tyr Asp
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PRT Oryctolagus cuniculus 6 Gln G
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agggcatcca ctctggcatc t 21 14 36
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99 PRT Oryctolagus cuniculus 20
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100 105 110 Val Arg Gly Gly Ala Val
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501 DNA Oryctolagus cuniculus 30
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85 90 95 Leu Thr Ile Thr Asp Val Gl
Page 265 and 266:
1 5 43 16 PRT Oryctolagus cunic
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gtctactaca tgaac 15 51 48 DNA O
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145 150 155 160 Ala Leu Gly Cys Leu
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gagcagctga aggagtccgg aggaggcctg gt
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Val Val Val Lys Arg Thr Val Ala Ala
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75 Ile Ile Gly Gly Phe Gly Thr Thr
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Oryctolagus cuniculus 83 atcattggt
Page 279 and 280:
Page 281 and 282:
tgggcgaaag gccgattcac catctccaaa ac
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145 150 155 160 Leu Asn Asn Phe 10
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108 12 PRT Oryctolagus cuniculus
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PRT Oryctolagus cuniculus 120 Ile
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125 Glu Ile Ser Lys Leu Glu Ser 1 5
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133 gaaatatcca aactggaatc t 21 134
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100 105 110 Val Arg Ser Leu Lys Tyr
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gcgaaaggcc gattcaccat ctccaagacc tc
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1 5 10 15 Val Gln Cys Gln Ser Val G
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gtcaccatca gttgccagtc cagtcagagt gt
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50 55 60 Gly Gln Arg Pro Lys Leu Le
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aattatggtg gtgatgaaag tttg 24 186
Page 309 and 310:
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Oryctolagus cuniculus 199 agcggcta
Page 313 and 314:
Page 315 and 316:
213 21 DNA Oryctolagus cuniculus
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65 70 75 80 Ala Lys Gly Arg Phe Thr
Page 319 and 320:
Page 321 and 322:
100 105 110 Leu Gly Ser Tyr Asp Cys
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Ala Tyr Asp Leu 1 242 375 DNA O
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Met Asp Thr Arg Ala Pro Thr Gln Leu
Page 327 and 328:
1 5 256 16 PRT Oryctolagus cuni
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DNA Oryctolagus cuniculus 264 ttc
Page 331 and 332:
Trp Ala Ser Thr Leu Ala Ser 1 5 27
Page 333 and 334:
Page 335 and 336:
284 11 PRT 115 120 125 Oryctolag
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tacgcgagtt gggcgaaagg ccgattcacc at
Page 339 and 340:
1 5 10 15 Val Gln Cys Gln Ser Val G
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aaaccagggc agcctcccaa gctcctgatc ta
Page 343 and 344:
65 70 75 80 Gly Val Pro Ser Arg Phe
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Page 347 and 348:
gtcattggcg atactgctgg ttatgcttat tt
Page 349 and 350:
1 5 10 < 210> 335 5 PRT Oryctola
Page 351 and 352:
Page 353 and 354:
Oryctolagus cuniculus 348 Gln Ala
Page 355 and 356:
Oryctolagus cuniculus 356 caggccag
Page 357 and 358:
Ser Thr Tyr Tyr Ile Tyr Trp Val Arg
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gacctggagt gtgacgatgc tgccacttac ta
Page 361 and 362:
Pro Ser Arg Phe Lys Gly Ser Gly Ser
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Page 365 and 366:
Page 367 and 368:
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DNA Oryctolagus cuniculus 407 agc
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1 5 10 413 7 PRT Oryctolagus cu
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65 70 75 80 Ala Lys Gly Arg Phe Thr
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atggagactg ggctgcgctg gcttctcctg gt
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450 atggacacga gggcccccac tcagctgct
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Val Ser Ala Ala Val Gly Gly Thr Val
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Ile Ile Ala Asn Ser Gly Thr Thr Phe
Page 387 and 388:
DNA Oryctolagus cuniculus 473 gag
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478 Gln Gln Gly Ala Thr Val Tyr Asp
Page 391 and 392:
Page 393 and 394:
492 Gln Ala Ser Glu Asn Ile Tyr Ser
Page 395 and 396:
500 caggccagtg agaacattta tagcttttt
Page 397 and 398:
50 55 60 Trp Ile Gly Ile Ile Thr Gl
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Oryctolagus cuniculus 515 atggagac
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523 122 PRT 115 120 Oryctolagus
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DNA Oryctolagus cuniculus 530 atg
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20 25 30 Val Ser Val Pro Val Gly As
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Oryctolagus cuniculus 544 Phe Ile
Page 409 and 410:
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Oryctolagus cuniculus 558 Gln Gln
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Oryctolagus cuniculus 566 caacaggg
Page 415 and 416:
PRT Oryctolagus cuniculus 572 Gln
Page 417 and 418:
DNA Oryctolagus cuniculus 580 cag
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aacaggggag agtgt 315 588 330 PRT
Page 421 and 422:
tacgtggacg gcgtggaggt gcataatgcc aa
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15 PRT Homo sapiens 598 Asp Lys
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Ser Lys Glu Ala Leu Ala Glu Asn Asn
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15 PRT Homo sapiens 617 Cys Leu
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626 Glu Gln Ala Arg Ala Val Gln Met
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15 PRT Homo sapiens 636 Asp Pro
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645 Leu Arg Ser Phe Lys Glu Phe Leu
Page 435 and 436:
PRT Homo sapiens 650 Asp Ile Gln
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20 25 30 Tyr Met Ser Trp Val Arg Gl
Page 439 and 440:
65 70 75 80 Gln Met Asn Ser Leu Arg
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Page 443 and 444:
gcaaaattta acttg 375 664 450 PRT
Page 445 and 446:
450 665 450 PRT Oryctolagus cun
Page 447 and 448:
Gly Lys 450 666 216 PRT Oryctol
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20 25 30 Pro Gly Thr Pro Leu Thr Le
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1 5 10 15 Val Gln Cys Gln Ser Leu G
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676 Met Glu Thr Gly Leu Arg Trp Leu
Page 455 and 456:
PRT Oryctolagus cuniculus 680 Met
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684 128 PRT 115 120 Oryctolagus
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100 105 110 Gly Tyr Ser Leu Arg Asn
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85 90 95 Arg Asp Asp Ser Ser Asp Tr
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85 90 95 Arg Asp Asp Ser Ser Asp Tr
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85 90 95 Ile Asp Asn Ala Phe Gly Gl
Page 467 and 468:
50 55 60 Ser Gly Ser Gly Thr Asp Ph
Page 469 and 470:
Lys Val Tyr Ala Cys Glu Val Thr His
Page 471 and 472:
195 200 205 Pro Ser Asn Thr Lys Val
Page 473 and 474:
Leu Ile Tyr Arg Ala Ser Thr Leu Ala
Page 475 and 476:
50 55 60 Trp Val Gly Ile Ile Tyr Gl
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35 40 45 Tyr Arg Ala Ser Thr Leu Al
Page 479 and 480:
212> PRT Homo sapiens 718 Val Ile
Page 481 and 482:
ttcagcggca gtggatctgg gacagacttc ac
Page 483 and 484:
PRT Homo sapiens 726 Met Glu Lys
Page 485 and 486:
210 215 220 Thr Ala Val Ala Arg Asn
Page 487 and 488:
195 200 205 Ser Asp His Ile Asn Phe
Page 489:
690 695 700 Pro Glu Asp Leu Lys Ser
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(19) 대한민국특허청(KR) (12) 공개특허공보(A) - Questel

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