(19) 대한민국특허청(KR) (12) 공개특허공보(A) - Questel

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Oryctolagus cuniculus 144 Ile Ser Tyr Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 145 12 PRT Oryctolagus cuniculus 145 Ser Leu Lys Tyr Pro Thr Val Thr Ser Asp Asp Leu 1 5 10 146 369 DNA Oryctolagus cuniculus 146 atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc 60 acatttgcag ccgtgctgac ccagacacca tcgtccgtgt ctgcagctgt gggaggcaca 120 gtcagcatca gttgccagtc cagtcagagt gtttatagta ataagtacct agcctggtat 180 cagcagaaac cagggcagcc tcccaagctc ctgatctact ggacatccaa actggcatct 240 ggggccccat cacggttcag cggcagtgga tctgggacac aattcactct caccatcagc 300 ggcgtgcagt gtgacgatgc tgccacttac tactgtctag gcgcttatga tgatgatgct 360 gataatgct 369 147 378 DNA Oryctolagus cuniculus 147 atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60 tcggtggaag agtccggggg tcgcctggtc aagcctgacg aaaccctgac actcacctgc 120 acagcctctg gattctccct ggagggcggc tacatgacct gggtccgcca ggctccaggg 180 aaggggctgg aatggatcgg aatcagttat gatagtggta gcacatacta cgcgagctgg 240 - 296 - 공개특허 10-2011-0112308
gcgaaaggcc gattcaccat ctccaagacc tcgtcgacca cggtggatct gaaaatgacc 300 agtctgacaa ccgaggacac ggccacctat ttctgcgtca gatcactaaa atatcctact 360 gttacttctg atgacttg 378 148 39 DNA Oryctolagus cuniculus 148 cagtccagtc agagtgttta tagtaataag tacctagcc 39 149 21 DNA Oryctolagus cuniculus 149 tggacatcca aactggcatc t 21 150 33 DNA Oryctolagus cuniculus 150 ctaggcgctt atgatgatga tgctgataat gct 33 151 15 DNA Oryctolagus cuniculus 151 ggcggctaca tgacc 15 152 48 DNA Oryctolagus cuniculus 152 atcagttatg atagtggtag cacatactac gcgagctggg cgaaaggc 48 - 297 - 공개특허 10-2011-0112308
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(51) Int. Cl. (19) 대한민국특
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특허청구의 범위 청구항 1
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서열 번호: 5에 적어도 85.7%
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청구항 1 내지 20중 어느 한
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청구항 38 청구항 34에 있어
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암(Pharyngeal Cancer), 갈색세
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청구항 41에 있어서, Ab1 항
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청구항 41에 있어서, 개체
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청구항 103에 있어서, 항-IL-
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톨페남산, 톨메틴, 발데콕
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IFN-감마, BAFF, CXCL13, IP-10, VE
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드, 또는 높은 엄밀도 조건
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서열 번호: 120에 적어도 50%
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청구항 160 청구항 140 내지
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약, 항히스타민제, 아프레
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탈리주맙, 네다플라틴, 네
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[0001] [0002] [0003] [0004] [0005]
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[0015] [0016] [0017] [0018] [0019]
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[0029] [0030] [0031] [0032] [0033]
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[0040] [0041] [0042] [0043] [0044]
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[0056] [0057] [0058] [0059] [0060]
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[0084] [0085] [0086] [0087] [0088]
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[0100] [0101] [0102] [0103] [0104]
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[0132] [0133] [0134] [0135] [0136]
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[0171] [0172] [0173] [0174] [0175]
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[0186] [0187] [0188] [0189] 한 참
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[0197] [0198] [0199] [0200] [0201]
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[0210] [0211] [0212] [0213] [0214]
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[0254] [0255] [0256] [0257] [0258]
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[0276] [0277] [0278] [0279] [0280]
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[0301] [0302] [0303] [0304] [0305]
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[0363] [0364] [0365] [0366] [0367]
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[0455] [0456] [0457] [0458] [0459]
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[0463] [0464] [0465] 333, 525 415,
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[0641] [0642] [0643] [0644] [0645]
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[0664] [0665] [0666] [0667] [0668]
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[0684] [0685] challenge to evaluate
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[0686] [0687] marrow transplantatio
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[0688] prostate cancer xenografts i
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[0689] [0690] [0691] [0692] [0693]
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[0699] [0700] [0701] [0702] [0703]
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도 4에서는 인간 IL-6의 100
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[0718] [0719] [0720] [0721] [0722]
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[0737] [0738] [0739] [0740] [0741]
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[0751] [0752] [0753] [0754] [0755]
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[0771] [0772] [0773] [0774] [0775]
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[0793] [0794] [0795] [0796] [0797]
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[1817] [1818] [1819] [1820] [1821]
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[1877] [1878] [1879] [1880] [1881]
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[1937] [1938] [1939] [1940] [1941]
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[1997] [1998] [1999] [2000] [2001]
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[2059] [2060] [2061] [2062] [2063]
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[2418] [2419] [2420] [2421] 서열
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도면2 - 187 - 공개특허 10-201
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도면4 - 189 - 공개특허 10-201
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도면6 - 191 - 공개특허 10-201
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도면8 - 193 - 공개특허 10-201
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도면10a - 195 - 공개특허 10-2
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도면10c - 197 - 공개특허 10-2
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도면10e - 199 - 공개특허 10-2
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도면12 - 201 - 공개특허 10-20
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도면14 - 203 - 공개특허 10-20
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도면16 - 205 - 공개특허 10-20
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도면18 - 207 - 공개특허 10-20
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도면20 - 209 - 공개특허 10-20
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도면22 - 211 - 공개특허 10-20
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도면24 - 213 - 공개특허 10-20
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도면26a 도면26b - 215 - 공개
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도면28 - 217 - 공개특허 10-20
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도면30 도면31 - 219 - 공개특
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도면33 - 221 - 공개특허 10-20
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도면35 - 223 - 공개특허 10-20
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도면36b - 225 - 공개특허 10-2
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도면37b - 227 - 공개특허 10-2
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도면39 - 229 - 공개특허 10-20
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도면41 - 231 - 공개특허 10-20
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도면43 - 233 - 공개특허 10-20
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도면45 - 235 - 공개특허 10-20
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도면47 - 237 - 공개특허 10-20
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도면49 - 239 - 공개특허 10-20
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도면51 - 241 - 공개특허 10-20
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도면53 - 243 - 공개특허 10-20
Page 245 and 246: 도면56 도면57 - 245 - 공개특
Page 247 and 248: 도면60 도면61 - 247 - 공개특
Page 249 and 250: Smith, Jeffrey T.L. Schatzman, Rand
Page 251 and 252: Leu Pro Gly Ala Arg Cys Ala Tyr Asp
Page 253 and 254: PRT Oryctolagus cuniculus 6 Gln G
Page 255 and 256: agggcatcca ctctggcatc t 21 14 36
Page 257 and 258: 99 PRT Oryctolagus cuniculus 20
Page 259 and 260: 100 105 110 Val Arg Gly Gly Ala Val
Page 261 and 262: 501 DNA Oryctolagus cuniculus 30
Page 263 and 264: 85 90 95 Leu Thr Ile Thr Asp Val Gl
Page 265 and 266: 1 5 43 16 PRT Oryctolagus cunic
Page 267 and 268: gtctactaca tgaac 15 51 48 DNA O
Page 269 and 270: 145 150 155 160 Ala Leu Gly Cys Leu
Page 271 and 272: gagcagctga aggagtccgg aggaggcctg gt
Page 273 and 274: Val Val Val Lys Arg Thr Val Ala Ala
Page 275 and 276: 75 Ile Ile Gly Gly Phe Gly Thr Thr
Page 277 and 278: Oryctolagus cuniculus 83 atcattggt
Page 281 and 282: tgggcgaaag gccgattcac catctccaaa ac
Page 283 and 284: 145 150 155 160 Leu Asn Asn Phe 10
Page 285 and 286: 108 12 PRT Oryctolagus cuniculus
Page 289 and 290: PRT Oryctolagus cuniculus 120 Ile
Page 291 and 292: 125 Glu Ile Ser Lys Leu Glu Ser 1 5
Page 293 and 294: 133 gaaatatcca aactggaatc t 21 134
Page 295: 100 105 110 Val Arg Ser Leu Lys Tyr
Page 299 and 300: 1 5 10 15 Val Gln Cys Gln Ser Val G
Page 301 and 302: gtcaccatca gttgccagtc cagtcagagt gt
Page 303 and 304: 50 55 60 Gly Gln Arg Pro Lys Leu Le
Page 307 and 308: aattatggtg gtgatgaaag tttg 24 186
Page 311 and 312: Oryctolagus cuniculus 199 agcggcta
Page 315 and 316: 213 21 DNA Oryctolagus cuniculus
Page 317 and 318: 65 70 75 80 Ala Lys Gly Arg Phe Thr
Page 321 and 322: 100 105 110 Leu Gly Ser Tyr Asp Cys
Page 323 and 324: Ala Tyr Asp Leu 1 242 375 DNA O
Page 325 and 326: Met Asp Thr Arg Ala Pro Thr Gln Leu
Page 327 and 328: 1 5 256 16 PRT Oryctolagus cuni
Page 329 and 330: DNA Oryctolagus cuniculus 264 ttc
Page 331 and 332: Trp Ala Ser Thr Leu Ala Ser 1 5 27
Page 333 and 334: 278 33 DNA Oryctolagus cuniculus
Page 335 and 336: 284 11 PRT 115 120 125 Oryctolag
Page 337 and 338: tacgcgagtt gggcgaaagg ccgattcacc at
Page 339 and 340: 1 5 10 15 Val Gln Cys Gln Ser Val G
Page 341 and 342: aaaccagggc agcctcccaa gctcctgatc ta
Page 343 and 344: 65 70 75 80 Gly Val Pro Ser Arg Phe
Page 347 and 348:
gtcattggcg atactgctgg ttatgcttat tt
Page 349 and 350:
1 5 10 < 210> 335 5 PRT Oryctola
Page 351 and 352:
343 15 DNA Oryctolagus cuniculus
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Oryctolagus cuniculus 348 Gln Ala
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Oryctolagus cuniculus 356 caggccag
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Ser Thr Tyr Tyr Ile Tyr Trp Val Arg
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gacctggagt gtgacgatgc tgccacttac ta
Page 361 and 362:
Pro Ser Arg Phe Lys Gly Ser Gly Ser
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10 PRT Oryctolagus cuniculus 385
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Page 367 and 368:
Page 369 and 370:
DNA Oryctolagus cuniculus 407 agc
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1 5 10 413 7 PRT Oryctolagus cu
Page 373 and 374:
Page 375 and 376:
65 70 75 80 Ala Lys Gly Arg Phe Thr
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atggagactg ggctgcgctg gcttctcctg gt
Page 379 and 380:
Page 381 and 382:
450 atggacacga gggcccccac tcagctgct
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Val Ser Ala Ala Val Gly Gly Thr Val
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Ile Ile Ala Asn Ser Gly Thr Thr Phe
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DNA Oryctolagus cuniculus 473 gag
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478 Gln Gln Gly Ala Thr Val Tyr Asp
Page 391 and 392:
Page 393 and 394:
492 Gln Ala Ser Glu Asn Ile Tyr Ser
Page 395 and 396:
500 caggccagtg agaacattta tagcttttt
Page 397 and 398:
50 55 60 Trp Ile Gly Ile Ile Thr Gl
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Oryctolagus cuniculus 515 atggagac
Page 401 and 402:
523 122 PRT 115 120 Oryctolagus
Page 403 and 404:
DNA Oryctolagus cuniculus 530 atg
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20 25 30 Val Ser Val Pro Val Gly As
Page 407 and 408:
Oryctolagus cuniculus 544 Phe Ile
Page 409 and 410:
Page 411 and 412:
Oryctolagus cuniculus 558 Gln Gln
Page 413 and 414:
Oryctolagus cuniculus 566 caacaggg
Page 415 and 416:
PRT Oryctolagus cuniculus 572 Gln
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DNA Oryctolagus cuniculus 580 cag
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aacaggggag agtgt 315 588 330 PRT
Page 421 and 422:
tacgtggacg gcgtggaggt gcataatgcc aa
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15 PRT Homo sapiens 598 Asp Lys
Page 425 and 426:
Ser Lys Glu Ala Leu Ala Glu Asn Asn
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15 PRT Homo sapiens 617 Cys Leu
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626 Glu Gln Ala Arg Ala Val Gln Met
Page 431 and 432:
15 PRT Homo sapiens 636 Asp Pro
Page 433 and 434:
645 Leu Arg Ser Phe Lys Glu Phe Leu
Page 435 and 436:
PRT Homo sapiens 650 Asp Ile Gln
Page 437 and 438:
20 25 30 Tyr Met Ser Trp Val Arg Gl
Page 439 and 440:
65 70 75 80 Gln Met Asn Ser Leu Arg
Page 441 and 442:
Page 443 and 444:
gcaaaattta acttg 375 664 450 PRT
Page 445 and 446:
450 665 450 PRT Oryctolagus cun
Page 447 and 448:
Gly Lys 450 666 216 PRT Oryctol
Page 449 and 450:
20 25 30 Pro Gly Thr Pro Leu Thr Le
Page 451 and 452:
1 5 10 15 Val Gln Cys Gln Ser Leu G
Page 453 and 454:
676 Met Glu Thr Gly Leu Arg Trp Leu
Page 455 and 456:
PRT Oryctolagus cuniculus 680 Met
Page 457 and 458:
684 128 PRT 115 120 Oryctolagus
Page 459 and 460:
100 105 110 Gly Tyr Ser Leu Arg Asn
Page 461 and 462:
85 90 95 Arg Asp Asp Ser Ser Asp Tr
Page 463 and 464:
85 90 95 Arg Asp Asp Ser Ser Asp Tr
Page 465 and 466:
85 90 95 Ile Asp Asn Ala Phe Gly Gl
Page 467 and 468:
50 55 60 Ser Gly Ser Gly Thr Asp Ph
Page 469 and 470:
Lys Val Tyr Ala Cys Glu Val Thr His
Page 471 and 472:
195 200 205 Pro Ser Asn Thr Lys Val
Page 473 and 474:
Leu Ile Tyr Arg Ala Ser Thr Leu Ala
Page 475 and 476:
50 55 60 Trp Val Gly Ile Ile Tyr Gl
Page 477 and 478:
35 40 45 Tyr Arg Ala Ser Thr Leu Al
Page 479 and 480:
212> PRT Homo sapiens 718 Val Ile
Page 481 and 482:
ttcagcggca gtggatctgg gacagacttc ac
Page 483 and 484:
PRT Homo sapiens 726 Met Glu Lys
Page 485 and 486:
210 215 220 Thr Ala Val Ala Arg Asn
Page 487 and 488:
195 200 205 Ser Asp His Ile Asn Phe
Page 489:
690 695 700 Pro Glu Asp Leu Lys Ser
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(19) 대한민국특허청(KR) (12) 공개특허공보(A) - Questel

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