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2286 J. Med. Plants Res. Table 2. Number of P. falciparum strains (schizontes) per µl of blood after 24 h incubation with various concentrations of alkaloids from A. leiocarpus and M. inermis. % of inhibition is reported as IC50 values. A. leiocarpus (Leaves) M. inermis (Leaves) M. inermis (Roots) Alkaloids extracts concentration in µg/ml P. falciparum strains number / µl before Alkaloids using Isolate 1 Isolate 2 Isolate 3 Isolate 4 Isolate 5 Isolate 6 Isolate 7 Inhibition IC50 540 1480 336 2780 1060 320 9940 % µg/ml P. falciparum strains number / µl after Alkaloids using 1250 0 0 0 0 0 0 0 100 125 4 40 0 0 0 0 32 99 12.5 160 400 96 64 20 16 9080 78 2.59 1.25 168 768 320 2176 1020 380 9800 32 1250 0 0 0 0 0 0 0 100 125 8 0 0 0 0 0 0 100 12.5 144 620 160 1320 64 0 6040 66 2.61 1.25 152 1060 352 1340 1820 264 8200 31 1250 0 0 0 0 0 0 0 100 125 0 0 16 0 8 0 8 100 12.6 164 820 176 1240 840 56 4280 67 2.35 1.25 264 1068 420 1280 1060 320 11360 30 Chloroquine IC50 for each 11.45 20.19 11.57 17.14 29.27 18.28 7.09 Isolate (nM) IC50 of chloroquine (CQ) on isolates and reference strains of Plasmodium falciparum (Pf). W2 and 3D7 are expressed in nM to validate the sensitivity of P. falciparum (IC50100 µg/ml, and
Percentage inhibition % of inhibition Percentage inhibition % of inhibition (A) (A) 120 (B) 120 100 100 100 99 120 100 100 99 80 78100 80 78 60 80 60 40 32 Serge et al. 2287 20 0 20 0 0 0 1 2 0 3 1 2 3 0 -log[alkaloids 4 extract] µg/ml 0 1 4 2 0 3 1 2 3 -log[alkaloids 4 extract] µg/m (C) 120 100 80 60 40 100 -log[alkaloids extract] µg/ml 100 % of inhibition 40 20 (A) (A) (B) (C) (C) 120 100 6760 100 20 0 0 0 1 2 3 4 0 1 2 3 -log[alkaloids 4 extract] µg/ml 30 % of inhibition 60 40 100 (B) 66 60 -log[alkaloids extract] µg/ml Figure 1. Antimalarial -log[alkaloids activity of extract] alkaloids µg/ml of A. leiocarpus and M. inermis: A/Alkaloids from A. leiocarpus leaves. B /Alkaloids from M. inermis leaves. C/ Alkaloids from M. inermis roots. Each point represents the average of the seven isolates after incubation for 24 h at 37°C. no more studies of these extracts were performed. However, our study showed considerable antiplasmodial activity for alkaloids from M. inermis and A. leiocarpus leaves, and for alkaloids from M. inermis roots (IC50
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Journal of Medicinal Plants Researc
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Editors Prof. Akah Peter Achunike E
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Electronic submission of manuscript
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Fees and Charges: Authors are requi
Page 9 and 10: Table of Contents: Volume 6 Number
Page 15 and 16: Figure 1. Chuanxiong Rhizoma (http:
Page 17 and 18: Table 1. Identification of main pea
Page 19 and 20: Table 3. Pharmacokinetic parameters
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Page 31 and 32: and it has been traced to South Ame
Page 33 and 34: Table 3. Results of phytochemical a
Page 37 and 38: (a) (b) (c) Figure 1. (a) Normal ce
Page 39 and 40: emedies in the south of Brazil. J.
Page 41 and 42: known fatty acids and terpenoids we
Page 43 and 44: Table 1. Renal function tests of ra
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Page 47 and 48: namely disruption of the vascular e
Page 49 and 50: Zayachkivska OS, Konturek SJ, Drozd
Page 51 and 52: β-carotene were purchased from Sig
Page 53 and 54: Figure 1. Effect of ethanol concent
Page 55 and 56: Table 3. Climatic and soil factors
Page 57 and 58: content of polysaccharides. Phospha
Page 59: Serge et al. 2285 Table 1. Relative
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Page 67 and 68: Table 3. Result of thin layer chrom
Page 71 and 72: Table 2. MIC of a compound 1 from c
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Page 81 and 82: Figure 12. Sensitivity of A. fumiga
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Page 89 and 90: Figure 2. Contd. at 2.0 mg/L yellow
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Page 97 and 98: ACKNOWLEDGMENTS The authors would l
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14 7 1 15 1 35 17 16 Imported plant
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Academy of Science Publishing House
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et al., 1996; van Wyk and Gericke,
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DPPH inhibition (%) DPPH % inhibiti
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% Mortality Concentration (µg/ml)
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information on plants used for the
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Table 1. Levels of independent vari
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Arbutin (mg/g) Co-solvent Figure 1.
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Arbutin (mg/g) Extraction pressure
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Table 3. Arbuitn content of Asian p
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Arbutin (mg/g) Extraction pressure
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Arbutin (mg/g) Extraction temperatu
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Table 1. Chemical composition of es
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Darjazi 2369 Table 2. Statistical a
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Table 3. Correlation matrix (number
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Table 1. Precision test. extraction
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Figure 2. Effect of different alcoh
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Table 6. Results of ANOVA. Nie et a
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Table 2. Plant data and MIC values
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exhibiting the polar extracts of P.
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Table 3. Contd. AcOEt ++ ++ ++ - Me
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Figure 1. Map of Ladakh region of I
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Warghat et al. 2391 Table 3. Summar
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Table 5. Inter-Population genetic i
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Excoffier L, Smouse PE, Quattro JM
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ice residue is an ideal raw materia
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DPPH• scavenging ratio(%) OD valu
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scavenging effect on free radical a
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our new CL system. Fenton reaction
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1 2 Time (s) Figure 2. Kinetic curv
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Wong et al., 2006). It can be seen
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Pan YM, Liang Y, Wang HS, Liang M (
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2422 J. Med. Plants Res. close cano
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2424 J. Med. Plants Res. Table 1. M
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2426 J. Med. Plants Res. Table 1. C
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2432 J. Med. Plants Res. Table 2. D
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2434 J. Med. Plants Res. Table 6. T
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2436 J. Med. Plants Res. budget dur
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2440 J. Med. Plants Res. Table 1. R
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2442 J. Med. Plants Res. Stability
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2444 J. Med. Plants Res. production
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2446 J. Med. Plants Res. Figure 2.
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2450 J. Med. Plants Res. Table 2. A
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2452 J. Med. Plants Res. Ghasemi Pi
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2454 J. Med. Plants Res. Table 1. I
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2456 J. Med. Plants Res. Table 3. M
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2460 J. Med. Plants Res. Department
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2462 J. Med. Plants Res. Table 3. E
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2466 J. Med. Plants Res. AOAC (2000
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2470 J. Med. Plants Res. Table 1. F
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2472 J. Med. Plants Res. Table 3. S
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2480 J. Med. Plants Res. Table 1. W
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2486 J. Med. Plants Res. components
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2490 J. Med. Plants Res. Inhibition
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2494 J. Med. Plants Res. can increa
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2500 J. Med. Plants Res. Flowering
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2502 J. Med. Plants Res. harvest in
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2524 J. Med. Plants Res. ACKNOWLEDG
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UPCOMING CONFERENCES 15th European
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