Final Program
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108 SUNDAY • MAY 15<br />
12:15 Post-Prematurity Respiratory Disease<br />
R. Keller, MD, San Francisco, CA<br />
12:45 Assessing Severity of Post-Prematurity Respiratory Disease<br />
P.E. Moore, MD, Nashville, TN<br />
1:00 Infant Lung Function Outcomes at 1 Year in ELGANs<br />
S. Davis, MD, Indianapolis, IN<br />
L6<br />
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE,<br />
DIVISION OF LUNG DISEASES, NIH<br />
MOLECULAR ATLAS OF LUNG DEVELOPMENT<br />
12:15 p.m. - 1:15 p.m. MOSCONE CENTER<br />
Room 2001/2003 (West Building, Level 2)<br />
Target Audience<br />
Providers of lung health, medical fellows in training, and basic researchers on<br />
lung biology, developmental biology, pediatrics, and informatics.<br />
Objectives<br />
At the conclusion of this session, the participant will be able to:<br />
• learn the newest datasets of LungMAP;<br />
• understand and learn the innovative technologies for molecular profiling and<br />
imaging of the developing lung;<br />
• learn how to access the LungMAP resources.<br />
Molecular Atlas of Lung Development (LungMAP) is an NHLBI-sponsored program.<br />
The overall goal of this program is to build an open-access reference resource by<br />
creating a comprehensive molecular atlas of the late-stage developing lung with data<br />
and reagents available to the research community. The atlas will integrate gene and<br />
protein expression profiles, transcriptome, epigenome, and other molecular<br />
characterizations with high-resolution anatomical information to provide molecular<br />
profiles of functionally or anatomically defined cell types in the developing lung.<br />
Participants in this session will learn about the newest data generated by the<br />
LungMAP, data analysis tools, and how to access the website, database and other<br />
publicly available resources of LungMAP.<br />
Chairing: R.F. Clark, PhD, Research Triangle Park, NC<br />
S. Lin, PhD, Bethesda, MD<br />
12:15 BREATH: A Web Accessible Database of Normal Human and<br />
Mouse Lung Development<br />
R.F. Clark, PhD, Research Triangle Park, NC<br />
12:27 Mass Spectrometry-Based Omics and High Throughput<br />
Imaging Characterization of Lung Development<br />
C. Ansong, PhD, Richland, WA<br />
12:39 Reconstructed Regulatory Networks Provide Novel Insights<br />
into Mechanisms of Postnatal Mouse Lung Development<br />
N. Ambalavanan, MD, Birmingham, AL<br />
12:51 LungMAP Postnatal Human Lung Tissue and Dissociated Cell<br />
Repository<br />
G.S. Pryhuber, MD, Rochester, NY<br />
L7<br />
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE,<br />
DIVISION OF LUNG DISEASES, NIH<br />
NEW INSIGHTS ABOUT SEVERE ASTHMA FROM<br />
THE NHLBI SEVERE ASTHMA RESEARCH<br />
PROGRAM<br />
12:15 p.m. - 1:15 p.m. MOSCONE CENTER<br />
Room 2006/2008 (West Building, Level 2)<br />
Target Audience<br />
Providers of lung health, especially providers who manage patients with<br />
asthma; investigators interested in mechanisms of disease in asthma.<br />
Objectives<br />
At the conclusion of this session, the participant will be able to:<br />
• learn new findings about clinical and molecular phenotypes of severe asthma;<br />
• review research being supported by NHLBI to improve understanding of severe<br />
asthma and accelerate progress toward new treatments;<br />
• improve understanding of how the clinical features of severe asthma varies in<br />
children and adults.<br />
In this session on work in progress in the NHLBI-sponsored severe asthma research<br />
program, there are four presentations planned to provide the learner with a<br />
cutting-edge, data-driven understanding of the clinical features of pediatric and adult<br />
severe asthma. Each presentation will cover the context, rationale and recent<br />
progress in addressing clinically relevant questions in severe asthma pathobiology,<br />
diagnosis and management, including baseline cross-sectional data on recruited<br />
healthy and asthmatic subjects, their response to systemic corticosteroids, risk<br />
factors for asthma exacerbations as well as advances in imaging for the detection of<br />
pathologic mucus and its association with clinical outcome.<br />
Chairing: S.E. Wenzel, MD, Pittsburgh, PA<br />
T. Croxton, MD, PhD, Bethesda, MD<br />
12:15 Age and Gender Impacts<br />
W.G. Teague, MD, Charlottesville, VA<br />
12:30 Phenotypic Characteristics<br />
L.C. Denlinger, MD, PhD, Madison, WI<br />
12:45 Identification of Intraluminal Mucus by CT Imaging<br />
E. Dunican, MD, San Francisco, CA<br />
1:00 Characterization of Steroid Responsiveness<br />
E. Israel, MD, Boston, MA<br />
L8<br />
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE,<br />
DIVISION OF LUNG DISEASES, NIH<br />
LESSONS LEARNED FROM THE NHLBI-SPONSORED<br />
TUBERCULOSIS SYSTEM BIOLOGY PROGRAM<br />
12:15 p.m. - 1:15 p.m. MOSCONE CENTER<br />
Room 2016/2018 (West Building, Level 2)<br />
Target Audience<br />
Providers of lung health, medical fellows in training, graduates, post-doctoral<br />
ATS 2016 • San Francisco