Final Program

TUESDAY • MAY 17 245
9:30 In Utero Second-Hand Smoke Exposure Accelerates
Urethane-Induced Lung Tumor Growth and Malignancy in Male
Mice/A. Noel, R. Xiao, L.R. Peterson, Z. Perveen, V. Le Donne,
D.B. Paulsen, A.L. Penn, Baton Rouge, LA, p.A4604
9:45 Mouse Models of Lung Cancer Initiated by Adenovirus
Expressing Cre Recombinase Also Target Alveolar
Macrophages/D. Tippimanchai, J. Poczobutt, K. Nolan, G.
Verzosa, H. Li, R. Nemenoff, S. Malkoski, Aurora, CO, p.A4605
10:00 The Autocrine and Paracrine Roles of Epithelial STAT3 in
K-ras Mutant Lung Cancer/M.S. Caetano, H.T. Van, E. Bugarin,
A.M. Cumpian, H. Zhang, S.E. Evans, I.I. Wistuba, C. Behrens, H.
Kadara, S.S. Watowich, S.J. Moghaddam, Houston, TX, p.A4606
10:15 Glycan Sulfation Modulates Dendritic Cell Biology and
Carcinoma Growth/M.M. Fuster, R. El Ghazal, X. Yin, S. Johns,
M. Macal, E. Zuniga, San Diego, CA, p.A4607
10:30 The Examination of CD47 and Its Potential Therapy Target
Study on the Migration and Invasion in Non-Small Cell Lung
Cancer/Q. Wang, H. Zhao, J. Wang, X. Du, E. Li, Dalian, China,
p.A4608
10:45 Comprehensive Assessment of the Human Lung Cancer
Tumor Immune Microenvironment Via a Novel
Immunohistochemistry Method/K.T. Meinhof, R. Remark, C.A.
Powell, M. Merad, S. Gnjatic, C.D. Becker, New York, NY, p.A4609
C21
BASIC SCIENCE CORE POSTER DISCUSSION SESSION
APPLYING ‘OMICS TECHNOLOGIES TO REVEAL
GENE REGULATORS AND BIOMARKERS IN LUNG
DEVELOPMENT AND DISEASE
9:00 a.m. - 11:00 a.m. MOSCONE CENTER
Room 2010/2012 (West Building, Level 2)
Poster Viewing 9:00-9:45
Discussion 9:45-11:00
Chairing: N. Kaminski, MD, New Haven, CT
M.W. Geraci, MD, Indianapolis, IN
C.E. Wheelock, PhD, Stockholm Sweden
401 Transcriptomic Changes Common to Diverse Chronic Lung
Diseases Indicate a Core Lung Response to Chronic
Injury/B.M. Cherry, B. Juan-Guardela, K. Sakamoto, N. Kaminski,
J. Herazo-Maya, New Haven, CT, p.A4610
402 Vascular Cell-Specific Genome-Wide Profiling of Epigenetic
Landscape Reveals Gene Regulatory Signatures in Human
Pulmonary Arterial Hypertension/P. Chelladurai, C. Kunne, C.
Weber, M. Schmoranzer, R.R. Notzold, W. Seeger, M. Looso,
U.-M. Bauer, S.S. Pullamsetti, Bad Nauheim, Germany, p.A4611
403 Circulating Exosomal MicroRNA Signature in Young Healthy
Adults Subjects Exposed to Intermittent Hypoxia and
Following Normoxic Recovery/A. Khalyfa, C. Zhang, A.A.
Khalyfa, A. Beaudin, A. Andrade, M.J. Poulin, D. Gozal, Chicago,
IL, p.A4612
404 Metabolomics Approach to Understanding the Pathogenesis of
Respiratory Syncytial Virus (RSV) Infection/K.N. Turi, M. Steinhoff,
M. Watanabe, L. Romick-Rosendale, M.L. Moore, L.J. Anderson, E.K.
Larkin, T. Gebretsadik, T.V. Harter, Nashville, TN, p.A4613
405 A Systems-Biology Approach to Identify a
YAP/TAZ-miR-130/301 Molecular Circuit Controlling Pulmonary
Fibrosis/J.H. Yoon, T. Bertero, K.A. Cottrill, S. Annis, B. Bhat, B.
Gochuico, J.C. Osorio, I.O. Rosas, K.J. Haley, B.N. Chau, S.Y.
Chan, Pittsburgh, PA, p.A4614
406 Metabolic Reprogramming in Pulmonary Hypertension as
Gleaned Through Mass Spectrometry-Based Metabolomics/A.
D’Alessandro, S. Riddle, H. Zhang, M. Li, A. Flockton, K.C.
Hansen, M.A. Fini, S. Pullamsetti, K.C. El Kasmi, K.R. Stenmark,
Aurora, CO, p.A4615
407 Desmoplakin (DSP) Variants Are Associated with Idiopathic
Pulmonary Fibrosis and with Differential Gene Expression in
Lung Tissue/S.K. Mathai, B.S. Pedersen, K. Smith, P. Russell, M.I.
Schwarz, K.K. Brown, M.P. Steele, J. Loyd, J.D. Crapo, E.K.
Silverman, D. Nickerson, T. Fingerlin, I.V. Yang, D.A. Schwartz,
Aurora, CO, p.A4616
408 Genome-Wide Assessment Reveals Marked Differences in the
Transcriptomes of Mononuclear Phagocytes in the Developing
Lung/E. Sajti, V. Link, C. Romanoski, G. Fonseca, T. Troutman, L.
Prince, C. Glass, La Jolla, CA, p.A4617
409 Automated Cell Type Prediction in Single Cell RNA-Seq
Analysis of the Lung/M. Guo, J.A. Whitsett, S.S. Potter, Y. Xu,
Cincinnati, OH, p.A4618
410 Meta-Analysis of Peripheral Blood Mononuclear Cell
Genome-Wide Expression Profiling in Pulmonary Arterial
Hypertension/A.J. Mazer, R. Cai, J. Sun, G. Graninger, B. Harper,
G. Ferreyra, R.L. Danner, M.A. Solomon, J.M. Elinoff, Bethesda,
MD, p.A4619
411 Precision Transcriptomes: Among a Population of Healthy
Smokers, What Are the Shared Vs Individual
Smoking-Responsive Genes in the Small Airway Epithelium
and Alveolar Macrophages?/Y. Strulovici-Barel, M.R. Staudt, J.
Salit, R.J. Kaner, A.E. Tilley, A.M. Rogalski, C. Hollmann, H. Bitter,
S.G. Pillai, H. Hilton, G. Wolff, C.S. Stevenson, S. Visvanathan,
J.S. Fine, J.G. Mezey, R.G. Crystal, New York, NY, p.A4620
412 Single Cell RNA-Seq Analysis of Fibrosis in Mouse Pulmonary
Fibrosis Models/A. Munivar, X. Yan, A. Tzouvelekis, T. Woolard,
K. Sakamoto, G. Deluliis, J. Herazo-Maya, Q. Li, M. Vukmirovic, N.
Aurelien, T. Adams, N. Kaminski, F. Ahangari, New Haven, CT,
p.A4621
413 Investigating the Diagnostic Potential of Circulating miRNA
Signatures in Pulmonary Arterial Hypertension/J. Iremonger,
A.M. Rothman, C. Rhodes, R. Condliffe, C.A. Elliot, D. Kiely, L.S.
Howard, S. Gibbs, J. Wharton, M.R. Wilkins, A. Lawrie, Sheffield,
United Kingdom, p.A4622
414 Sputum Transcriptomics Identifies Co-Expressed Network
Signatures Associated with FEV1 and Sputum Neutrophilia in
Severe Asthmatics on Oral Corticosteroids/C.H.S. Kuo, S.
Pavlidis, M. Loza, F. Baribaud, A. Rowe, I. Pandis, C. Rossios, R.
Lutter, R. Djukanovic, P.J. Sterk, K.F. Chung, I. Adcock, Y. Kuo,
London, United Kingdom, p.A4623
TUESDAY MORNING
ATS 2016 • San Francisco