Final Program

TUESDAY • MAY 17 243
10:00 Whole Genome Analysis of 5,310 Globally Diverse
Mycobacterium Tuberculosis Isolates Reveals Consistent
Ordering in the Emergence of Drug Resistance/K.A. Cohen, A.
Manson McGuire, T. Abeel, C. Desjardins, A.S. Pym, A.M. Earl,
Boston, MA, p.A4568
10:15 Feasibility of a Streamlined SIngle-saMPLE (SIMPLE) TB
Diagnosis and Treatment Initiation Strategy in Uganda/P.B.
Shete, T. Nalugwa, K. Farr, C. Ojok, M. Nantale, L. Chaisson, D.
Dowdy, A. Katamba, D. Moore, A. Cattamanchi, San Francisco,
CA, p.A4569
10:30 High Dose Moxifloxacin for Drug Resistant Tuberculosis; is
600mg the Optimal Dose in High Resistance Settings?/S.R.
Ganatra, Z.F. Udwadia, J.B. Mullerpattan, R.A. Banka, A.R.
Gandhare, M.A. Sadani, C.S. Rodrigues, Mumbai, India, p.A4570
10:45 Prospective Study of Extensively Drug Resistant Tuberculosis
and HIV Co-Infection (PROX) in KwaZulu-Natal, South Africa/K.
Yuengling, N. Padayatchi, A. Wolf, C.R. Horsburgh, M. O’Donnell,
New York, NY, p.A4571
C16
MINI SYMPOSIUM
PEDIATRIC IMAGING: WHAT’S NEW
9:00 a.m. - 11:00 a.m. MOSCONE CENTER
Chairing: T.E. Robinson, MD, Palo Alto, CA
M.O. Wielpuetz, MD, Heidelberg, Germany
Oral Presentations
Room 3003/3005 (West Building, Level 3)
9:00 Pulmonary MRI to Evaluate Neonatal Lung Growth in
Congenital Diaphragmatic Hernia/M.A. Schopper, L.L. Walkup,
J.A. Tkach, N.S. Higano, F.Y. Lim, B.E. Haberman, J.C. Woods,
P.S. Kingma, Cincinnati, OH, p.A4572
9:15 Dependence of MRI-Determined Lung Volume on Gestational
Age: A Comparison between Healthy and IUGR Fetuses/E.
Stirrat, J. Zheng, R. Ramroop, C. Macgowan, M. Seed, G.E.
Santyr, Toronto, Canada, p.A4573
9:30 Quantification of Neonatal Lung Parenchymal Density Via
Ultra-Short Echo-Time (UTE) Magnetic Resonance Imaging
(MRI)/N.S. Higano, L.L. Walkup, A. Hahn, R. Thomen, S. Merhar,
P.S. Kingma, J.A. Tkach, S. Fain, J.C. Woods, Cincinnati, OH,
p.A4574
9:45 Automated Lung Segmentation and Longitudinal Air Trapping
Quantification in Chronic Lung Disease of Prematurity/A.
Mansoor, G.F. Perez, K. Pancham, A. Jain, K. Okada, M.G.
Linguraru, G.R. Nino, Washington, DC, p.A4575
10:00 The Relationship of Lung Function in Cystic Fibrosis to
Volume of Hypo Perfused Lung Volume and Systemic Arterial
Blood Flow to the Lung/M. Alexander, K. Eaton, R.J. Fleck, J.C.
Woods, A. Brody, J.P. Clancy, Cincinnati, OH, p.A4576
10:15 Hyperpolarized 129Xe MRI Is Sensitive to Impaired Ventilation
in Pediatric Cystic Fibrosis Patients with Normal
Spirometry/L.L. Walkup, R. Thomen, T. Akinyi, K. Ruppert, Z.I.
Cleveland, J.P. Clancy, J.C. Woods, Cincinnati, OH, p.A4577
10:30 Stationary Digital Chest Tomosynthesis of Cystic Fibrosis/Y.Z.
Lee, J.L. Goralski, A. Hartman, G. Wu, S. Donaldson, R.C.
Boucher, O. Zhou, Chapel Hill, NC, p.A4578
10:45 Longitudinal Automated Airway and Air-Trapping Analysis on
CT in School Age Children with Mild Cystic Fibrosis Lung
Disease/M.O. Wielpuetz, T.E. Robinson, P. Konietzke, C.-P.
Heussel, H.-U. Kauczor, C. Galban, D.N. Cornfield, D. Savage, B.
Newman, O. Weinheimer, Heidelberg, Germany, p.A4579
C17
MINI SYMPOSIUM
FASCINATING MECHANISMS IN LUNG FIBROSIS
9:00 a.m. - 11:00 a.m. MOSCONE CENTER
Oral Presentations
Room 2020/2022 (West Building, Level 2)
9:00 TAZ Activation Promotes Fibroblast-Mediated Matrix Stiffening
in the Lung/D. Sicard, Q. Tan, K.M. Choi, D. Mehra, D. Lagares,
C. Probst, A.M. Tager, D.J. Tschumperlin, Rochester, MN, p.A4580
9:15 Expression of the Surfactant Protein C Mutant SP-CI73T in
Mice Results in Dose Dependent Disruption of Lung
Development and Age Related Diffuse Parenchymal Lung
Remodeling In Adults/S.-I. Nureki, Y. Tomer, S.J. Russo, V.
Nguyen, S. Mulugeta, M.F. Beers, Philadelphia, PA, p.A4581
9:30 Therapeutic Targeting of Fibroblast Durotaxis: A Novel Class
of Anti-Fibrotic Therapies for IPF/D. Lagares, P. Grasberger, C.
Probst, A. Engler, A.M. Tager, Charlestown, MA, p.A4582
9:45 Impaired Myofibroblast Dedifferentiation Contributes to
Non-Resolving Fibrosis in Aging/L. Hecker, N.J. Logsdon, Y.-J.
Shin, J.G.N. Garcia, V.J. Thannickal, Tucson, AZ, p.A4583
10:00 Characterizing the Diversity of Pathologic Fibroblasts Across
Solid Organs Using Single Cell RNAseq/K.-H. Sun, Y. Chang, I.
Driver, A. King, M. Fricano, N.I. Reed, J.R. Rock, D. Sheppard, San
Francisco, CA, p.A4584
10:15 RTEL1 Regulates Cell Cycle and DNA Repair Mechanisms in
Alveolar Epithelial Cells/J.A. Kropski, J. Cogan, D.B. Mitchell,
C.L. Calvi, C. Markin, E.T. Garnett, D.A. Schwartz, L.R. Young,
W.E. Lawson, M.P. Steele, J. Loyd, Z. Zhao, J.A. Phillips, III, T.S.
Blackwell, Nashville, TN, p.A4585
10:30 Hippo Signaling is Deranged in Idiopathic Pulmonary Fibrosis
and Correlates with Disease Severity/D.E. Wagner, K. Mutze,
H.B. Schiller, R. Costa, N. Kaminski, M. Konigshoff, Munich,
Germany, p.A4586
10:45 The Host Response to the Lung Microbiome in Idiopathic
Pulmonary Fibrosis/N. Tanabe, J.E. McDonough, M. Sze, S.
Verleden, D. Kinose, D.M. Vasilescu, R. Ng, B.T. Jin, N. Kaminski,
W. Wuyts, B.M. Vanaudenaerde, J.C. Hogg, Vancouver, Canada,
p.A4587
TUESDAY MORNING
ATS 2016 • San Francisco