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402 WEDNESDAY • MAY 18<br />

D96<br />

MINI SYMPOSIUM<br />

DAMAGING EFFECTS OF INHALED PARTICULATES<br />

1:30 p.m. - 3:30 p.m. MOSCONE CENTER<br />

Chairing:<br />

Oral Presentations<br />

Room 2006/2008 (West Building, Level 2)<br />

1:30 Acute Exposure to Electronic Cigarettes in Healthy<br />

Nonsmokers Leads to Global Transcriptome Changes in Distal<br />

Airway Epithelium and Alveolar Macrophages/M.R. Staudt, J.<br />

Salit, A.E. Tilley, R.J. Kaner, F. Agosto-Perez, C. Hollmann, R.G.<br />

Crystal, New York, NY, p.A7512<br />

1:45 MTOR Suppresses Cigarette Smoke-Induced Airway<br />

Inflammation and Emphysema/J.S. Zhou, J. Liu, Y. Wang, Z.Y. Li,<br />

S.M. Ying, W. Li, H.H. Shen, Z.H. Chen, Hang Zhou, China, p.A7513<br />

2:00 Ergothioneine Protects Lung Epithelial Cells from Tobacco<br />

Smoke-Induced Oxidative Damage In Vitro and In Vivo/S.<br />

Nickel, M. Selo, C. Clerkin, B. Talbot, J. Walsh, N. Nakamichi, Y.<br />

Kato, P. Reynolds, J. Lewis, C. Ehrhardt, Dublin, Ireland, p.A7514<br />

2:15 MKK3 Mediates Inflammatory Response and Mitochondrial<br />

Dysfunction After Cigarette Smoke Injury/A. Srivastava, S.<br />

Erramilli, P.J. Lee, P. Mannam, New Haven, CT, p.A7515<br />

2:30 Macrophage Migration Inhibitory Factor (MIF) Accelerates DNA<br />

Repair Via Its Receptor CD74 in a Novel In-Vitro Model of Cigarette<br />

Smoke Mediated Endothelial Dysfunction/T. Baker, M. Haslip, L.<br />

Leng, R. Bucala, P.J. Lee, M. Sauler, New Haven, CT, p.A7516<br />

2:45 RAGE Contributes to Particulate-Induced Lung Function Loss<br />

and Hyperreactivity: Mitigating the Persistent Effects of a<br />

Single Intense Particulate Exposure/S. Kwon, S.H. Haider, E.J.<br />

Caraher, G. Crowley, A.K. Lee, M. Ebrahim, D.J. Prezant, A.M.<br />

Schmidt, A. Nolan, New York, NY, p.A7517<br />

3:00 Metformin Attenuates Particulate Matter Air Pollution Induced<br />

Thrombosis by Inhibiting Mitochondrial ROS Upstream of<br />

CRAC Channels in Alveolar Macrophages/S. Soberanes, A.<br />

Jairaman, M. Chi, A.Y. Meliton, J. Cho, F.J. Gonzalez-Gonzalez,<br />

A.C. Mc Quattie-Pimentel, R. Piseaux, S. Weinberg, H.R. Perlman,<br />

N.S. Chandel, A.V. Misharin, M. Prakriya, G.M. Mutlu, G.S.<br />

Budinger, Chicago, IL, p.A7518<br />

3:15 Inhibition Of EGF Receptor Signaling Decreases Agricultural<br />

Dust-Mediated Lung Inflammatory Responses In Vivo and In<br />

Vitro/D.J. Romberger, T.M. Nordgren, A.J. Heires, N.A. Schulte,<br />

M.L. Toews, Omaha, NE, p.A7519<br />

D97<br />

MINI SYMPOSIUM<br />

IMAGING AND MODELING: INSIGHTS INTO LUNG<br />

STRUCTURE AND FUNCTION<br />

1:30 p.m. - 3:30 p.m. MOSCONE CENTER<br />

Room 2002/2004 (West Building, Level 2)<br />

Chairing: K.R. Lutchen, PhD, Boston, MA<br />

C.C. Hsia, MD, Dallas, TX<br />

M.H. Tawhai, PhD, Auckland, New Zealand<br />

Oral Presentations<br />

1:30 Postnatal Development of Pulmonary AciniA in Rats/T.P.<br />

Cremona, D. Haberthur, E. Yao, S. Barre, M. Stampanoni, J.C.<br />

Schittny, Bern, Switzerland, p.A7520<br />

1:45 Deposited Particle Concentrations in Infant, Child, and Adult<br />

Image-Based Computational Fluid Dynamics (CFD)<br />

Models/J.M. Oakes, S.C. Roth, I.E. Vignon-Clementel, S.C.<br />

Shadden, Berkeley, CA, p.A7521<br />

2:00 Imaging a Single Slice Provides a Representative Measure of<br />

Specific Ventilation in a Normal Lung: A Computational<br />

Modeling Study/K.S. Burrowes, W. Kang, G.K. Prisk, M. Tawhai,<br />

Oxford, United Kingdom, p.A7522<br />

2:15 Comparison of Regional Ventilation and Lung Deformation for<br />

Asthmatic Vs. Healthy Human Lungs Using 4D-CT Image<br />

Data/N. Jahani, S. Choi, J. Choi, E.A. Hoffman, A.P. Comellas, J.N.<br />

Kline, C.-L. Lin, Iowa City, IA, p.A7523<br />

2:30 Regional Increase in Airway Wall Thickness Could Explain<br />

Increase in Ventilation Defects (VDefs) and Heterogeneity in<br />

Ventilation in Asthma/T. Winkler, C. Thamrin, C.S. Farah, G.G.<br />

King, Boston, MA, p.A7524<br />

2:45 Biomechanical Model of Inflammation-Induced Airway Smooth<br />

Muscle Mass Accumulation and Extracellular Matrix<br />

Deposition in an Ovalbumin Murine Model of Asthma/M.R. Hill,<br />

A.L. Tatler, R.D. O’Dea, C.K. Billington, A.E. John, K. Deacon, S.R.<br />

Johnson, B.S. Brook, Nottingham, United Kingdom, p.A7525<br />

3:00 Novel Biomarkers of Lung Parenchyma Destruction and<br />

Emphysema Progression in COPD Using Inhaled Gas MRI<br />

Morphometry/E. Lessard, A. Ouriadov, D.P. Capaldi, D.G.<br />

McCormack, G. Parraga, London, Canada, p.A7526<br />

3:15 Automated Quantitative Evaluation of Alveolar Structure on<br />

Confocal Laser Endomicroscopy/D. Bondesson, T. Gaass, J.<br />

Behr, F. Reichenberger, J. Dinkel, E. Silbernagel, Munich,<br />

Germany, p.A7527<br />

D98<br />

MINI SYMPOSIUM<br />

AFTER SERVE-HF: NOW WHAT?<br />

1:30 p.m. - 3:30 p.m. MOSCONE CENTER<br />

Chairing: S. Javaheri, MD, Cincinnati, OH<br />

M. Arzt, MD, Regensburg, Germany<br />

M. D’Ortho, MD, PhD, Creteil, France<br />

Oral Presentations<br />

Room 2001/2003 (West Building, Level 2)<br />

1:30 Morbidity and Mortality of Chronic Heart Failure (CHF) Patients<br />

Treated by Adaptative Servo-Ventilation (ASV): Interim Data of<br />

the FACE Multicentre National Cohort Study/R. Tamisier, T.<br />

Damy, J.-M. Davy, P. Levy, F. Goutorbe, L. Morin, J.L. Pepin, M.-P.<br />

D’Ortho, Grenoble, France, p.A7528<br />

ATS 2016 • San Francisco

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