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242 TUESDAY • MAY 17<br />

Target Audience<br />

All clinicians, basic researchers, and other lung health care professionals<br />

looking to learn about state of the art developments in stem cell biology and<br />

their applications to lung diseases<br />

Objectives<br />

At the conclusion of this session, the participant will be able to:<br />

• appreciate the current state of the art with respect to stem cell biology;<br />

• appreciate the current state of the art with respect to cancer stem cells;<br />

• appreciate applications of stem cell and cancer stem cell biology to<br />

respiratory diseases and critical illnesses.<br />

The potential for use of stem cells to prevent or treat human disease has led to<br />

unprecedented growth of the field of regenerative medicine. Moreover,<br />

increasing evidence demonstrates the feasibility of utilizing an individual's own<br />

cells in developing potential stem cell-based therapeutic approaches: the<br />

ultimate in personalized medicine. This symposium will provide a strong basic<br />

scientific and clinical rationale and current state of the art in this rapidly<br />

developing area. The speakers are all accomplished stem cell investigators<br />

from outside the respiratory field who will bring new knowledge and perspective<br />

that will help guide future developments in lung regenerative medicine.<br />

Chairing: D.J. Weiss, MD, PhD, Burlington, VT<br />

D.N. Kotton, MD, Boston, MA<br />

9:00 Normal and Neoplastic Stem Cells<br />

I. Weissman, MD, Stanford, CA<br />

9:30 Imaging Cancer Heterogeneity and Therapy Resistance in Real<br />

Time<br />

T. Reya, PhD, La Jolla, CA<br />

10:00 Interspecific Blastocyst Complementation: A Novel Approach<br />

to Generate Functional Organs<br />

T. Rashid, MD, London United Kingdom<br />

10:30 Defining the Lung Cell By Cell<br />

M. Krasnow, PhD, Palo Alto, CA<br />

C14<br />

MINI SYMPOSIUM<br />

FINDING THE SWEET SPOT BETWEEN TOO MUCH<br />

AND TOO LITTLE CARE<br />

9:00 a.m. - 11:00 a.m. MOSCONE CENTER<br />

Chairing: R.S. Wiener, MD, MPH, Boston, MA<br />

A. Garland, MD, MA, Winnipeg, Canada<br />

Oral Presentations<br />

Room 307 (South Building, Esplanade Level)<br />

9:00 ICU Admission Does Not Confer a Survival Benefit for COPD,<br />

CHF, and AMI/T.S. Valley, M.W. Sjoding, A.M. Ryan, T.J.<br />

Iwashyna, C.R. Cooke, Ann Arbor, MI, p.A4556<br />

9:15 Adoption and De-Adoption of Adjuvant Treatments for Acute<br />

Respiratory Failure/L. Munshi, E. Fan, H. Wunsch, H.<br />

Gershengorn, N.D. Ferguson, T. Stukel, G.D. Rubenfeld, Toronto,<br />

Canada, p.A4557<br />

9:30 Hospital Volume and Outcomes of Noninvasive Ventilation in<br />

Patients Hospitalized with an Acute Exacerbation of<br />

COPD/M.S. Stefan, P.K. Lindenauer, M.-S. Shieh, P. Pekow, K.<br />

Fisher, N. Hill, Springfield, MA, p.A4558<br />

9:45 Associations Between Hospital Non-Invasive and Invasive<br />

Mechanical Ventilation Utilization in Acute Exacerbations of<br />

Chronic Obstructive Pulmonary Disease/A.B. Mehta, A.J.<br />

Walkey, Boston, MA, p.A4559<br />

10:00 Gender Differences in Appropriate Treatment for Chronic<br />

Obstructive Pulmonary Disease/S. Rinne, A.H. Gerity, L.M.<br />

Thayer, C.-F. Liu, M.A. Cook, L.A. Bastian, New Haven, CT,<br />

p.A4560<br />

10:15 Diagnosis and Over-Diagnosis of Asthma in Canadian<br />

Adults/S.D. Aaron, K. Vandemheen, L.-P. Boulet, J.M. FitzGerald,<br />

M. Ainslie, S. Gupta, C. Lemiere, S. Field, A. McIvor, P. Hernandez,<br />

I. Mayers, Ottawa, Canada, p.A4561<br />

10:30 Evaluating the Costs of IMRT vs 3D-RT in Stage III Non-Small<br />

Cell Lung Cancer/M.S. Kale, G. Mhango, M. Bonomi, A.<br />

Federman, K. Sigel, K. Rosenzweig, J.P. Wisnivesky, New York,<br />

NY, p.A4562<br />

10:45 Procedural Aggressiveness in Veterans with Stage<br />

IV Non-Small Cell Lung Cancer at End of Life/M.H. Tukey, R.<br />

Youssef, K. Faricy-Anderson, V. Mor, Providence, RI, p.A4563<br />

C15<br />

MINI SYMPOSIUM<br />

TB GAME CHANGERS: DIAGNOSTICS, HIV,<br />

DRUG-RESISTANCE, AND TREATMENT<br />

9:00 a.m. - 11:00 a.m. MOSCONE CENTER<br />

Chairing: R. Reves, MD, MSc, Denver, CO<br />

P. Nahid, MD, MPH, San Francisco, CA<br />

C. Daley, MD, Denver, CO<br />

Oral Presentations<br />

Room 3016/3018 (West Building, Level 3)<br />

9:00 Tuberculosis Screening in People Living with HIV Based on<br />

Plasma Cytokine and Chemokine Levels/L.C. Strnad, E. Chang,<br />

L. Chaisson, R.K. Ravindran, P.A. Luciw, I.H. Khan, A.<br />

Cattamanchi, San Francisco, CA, p.A4564<br />

9:15 Intensified Tuberculosis Case-Finding Among People Living<br />

with HIV: Diagnostic Yield of Xpert MTB/RIF, Urine<br />

Lipoarabinomannan and Liquid Culture/C. Yoon, F. Semitala, E.<br />

Atuhumuza, L. Asege, S. Mwebe, J. Katende, A. Andama, D.<br />

Armstrong, D. Dowdy, M. Kamya, A. Cattamanchi, San Francisco,<br />

CA, p.A4565<br />

9:30 Modifiers to the Infectiousness of HIV Seropositive<br />

Tuberculosis Patients: A Household Contact Study from<br />

Sub-Saharan Africa/L. Martinez, J.N. Sekandi, M.E. Castellanos,<br />

S. Zalwango, C.C. Whalen, Athens, GA, p.A4566<br />

9:45 Frequency and Distribution of Tuberculosis<br />

Resistance-Associated Mutations in a Multisite Study/S.B.<br />

Georghiou, D. Catanzaro, R.S. Garfein, V. Crudu, C. Rodrigues,<br />

T.C. Victor, A. Catanzaro, T.C. Rodwell, La Jolla, CA, p.A4567<br />

ATS 2016 • San Francisco

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