Final Program

322 TUESDAY • MAY 17
2:45 Long-Term Exposure to Ozone and Accelerated Progression of
Percent Emphysema and Decline in Lung Function: The MESA
Air and Lung Studies/M. Wang, R.G. Barr, E.A. Hoffman, J.
Madrigano, C.P. Aaron, P.D. Sampson, L. Sheppard, S. Vedal, J.
Kaufman, Seattle, WA, p.A6163
3:00 Genetic Ancestry is Associated with Baseline Lung Function,
CT-Scan Emphysema, and COPD Risk in African Americans
and Hispanics from SPIROMICS/V.E. Ortega, E.A. Hoffman, E.J.
Ampleford, G.A. Hawkins, R.G. Barr, D.J. Couper, M.K. Han, R.
Kanner, E. Kleerup, F.J. Martinez, S.I. Rennard, P.G. Woodruff,
D.A. Meyers, E.R. Bleecker, Winston-Salem, NC, p.A6164
3:15 Associations Between Smoking, Telomere Length and Lung
Function Decline: Findings from a Population-Based
Longitudinal Study/P. Andujar, D. Courbon, E. Bizard, E. Marcos,
S. Adnot, P. Demoly, I. Pin, G. Thabut, J. Boczkowski, B. Leynaert,
Creteil, France, p.A6165
3:30 Lung Cancer-Specific Mortality Reduction With CT Screening:
Outcomes According to Airflow Limitation in the ACRIN NLST
Sub-Study (N=18,475)/R.P. Young, F. Duan, E. Greco, R.J.
Hopkins, C. Chiles, G.D. Gamble, D. Aberle, Auckland, New
Zealand, p.A6166
3:45 Microalbuminuria Predicts the Incidence of Severe Chronic
Lower Respiratory Disease Exacerbations in Older Adults: The
Multi-Ethnic Study of Atherosclerosis (MESA)-Lung Study/E.C.
Oelsner, M.E. Grams, D.R. Jacobs, Jr., R. Kronmal, G.T. O’Connor,
D. Rabinowitz, R.P. Tracy, R.G. Barr, New York, NY, p.A6167
4:00 Blood Eosinophils Poorly Correlate with Sputum Eosinophils,
and Have Few Associations with Spirometry, Clinical and
Quantitated Computed Tomography Measures Compared to
Sputum Eosinophils in the SPIROMICS Cohort/A.T. Hastie, N.E.
Alexis, C. Doerschuk, N.N. Hansel, S. Christenson, N. Putcha, V.E.
Ortega, S.P. Peters, MD, PhD, R.G. Barr, D.J. Couper, E.A. Hoffman,
R. Kanner, E. Kleerup, F.J. Martinez, P.G. Woodruff, M.K. Han, D.A.
Meyers, J.L. Curtis, E.R. Bleecker, Winston-Salem, NC, p.A6168
C98
MINI SYMPOSIUM
AIRWAY REMODELING IN COPD AND ASTHMA
2:15 p.m. - 4:15 p.m. MOSCONE CENTER
Room 2016/2018 (West Building, Level 2)
Chairing: T. Hackett, PhD, Vancouver, Canada
H. Meurs, PhD, Groningen, Netherlands
A.L. James, MD, MBBS, PhD, Nedlands, Australia
Oral Presentations
2:15 Investigating the Features of Small Airway Obstruction in COPD:
Obstructed Small Airways Are an Early Feature of Mild and
Moderate Disease/S. Booth, H.-K. Koo, D.M. Vasilescu, L.
Mostaco-Guidolin, J.C. Hogg, T.-L. Hackett, Vancouver, Canada,
p.A6169
2:30 Brain Derived Neurotrophic Factor Effects on Asthmatic
Airway Smooth Muscle: A Profile of Epigenetic Regulation/
L.J. Manlove, G.R. Saint-Croix, M. Freeman, M.A. Thompson, C.
Pabelick, Y.S. Prakash, Rochester, MN, p.A6170
2:45 Quantitative Assessment of Airway Remodeling with
Birefringence Microscopy: Phenotyping Asthma/M.J. Suter,
D.C. Adams, L.P. Hariri, A.J. Miller, J.A. Holz, M.V. Szabari, R.S.
Harris, J.L. Cho, J.W. Griffith, D.L. Hamilos, A.D. Luster, B.D.
Medoff, Boston, MA, p.A6171
3:00 Heterogeneity of Airway Remodeling Contributes to Airway
Hyperresponsiveness in Asthma/C.D. Pascoe, P.D. Pare, G.M.
Donovan, Winnipeg, Canada, p.A6172
3:15 Novel Non-Linear Optical Imaging to Understand the
Composition of Fibrilar Collagen and Elastin in Remodeled
Asthmatic Airways/L.B. Mostaco-Guidolin, E.T. Osei, S.
Hajimohammadi, J. Ullah, T.-L. Hackett, Vancouver, Canada,
p.A6173
3:30 Mast Cell Tryptase Activates Matrix Metalloproteinase-1
Causing Matrix Remodelling, Airway Smooth Muscle Growth
and Airway Obstruction During Asthma Exacerbations/S.
Naveed, D.J. Jackson, D. Clements, C. Reynolds, D. Shaw, S.L.
Johnston, S.R. Johnson, Nottingham, United Kingdom, p.A6174
3:45 Fibulin-1 Plays Critical Roles in the Pathogenesis of
Pulmonary Diseases/P.M. Hansbro, G. Liu, M.A. Cooley, A.G.
Jarnicki, A.C.-Y. Hsu, P.M. Nair, T.J. Haw, M. Fricker, S.L. Gellatly,
R.Y. Kim, M.D. Inman, G. Tjin, P.A. Wark, J.C. Horvat, B.G. Oliver,
W.S. Argraves, D.A. Knight, J.K. Burgess, New Lambton Heights,
Australia, p.A6175
4:00 MMP-13 is a Critical Driver of Lung Destruction in a Viral
Exacerbation Model of COPD/M.P. Goldklang, F. Cvetkovski, D.
Turner, R. Xiao, T. Zelonina, K. Stearns, J. Trischler, P.
Sklepkiewicz, P. Elkington, D. Farber, J. D’Armiento, New York,
NY, p.A6176
C99
MINI SYMPOSIUM
BEYOND THE NATIONAL LUNG SCREENING TRIAL
2:15 p.m. - 4:15 p.m. MOSCONE CENTER
Chairing: C.G. Slatore, MD, Portland, OR
M.K. Gould, MD, MS, Pasadena, CA
Featured Speaker
Room 306/308 (South Building, Esplanade Level)
2:15 The Future of Lung Cancer Screening/R.S. Wiener, MD, MPH,
Boston, MA,
Oral Presentations
2:30 Using Electronic Health Records to Assess Eligibility for Lung
Cancer Screening: An Examination of Capture and Reliability of
Smoking History Data/L. Sakoda, G. Minowada, G. Mogel, V. Lee,
N. Gordon, P. Doria-Rose, L. Kushi, L. Habel, Oakland, CA, p.A6177
2:45 Airflow Limitation and Lung Cancer Risk in a Large
Prospective Screening Study (NLST-ACRIN Cohort Analysis,
N=18, 714)/R.J. Hopkins, R.P. Young, F. Duan, C. Chiles, E.
Greco, G.D. Gamble, D. Aberle, Auckland, New Zealand, p.A6178
ATS 2016 • San Francisco