Final Program

TUESDAY • MAY 17 295
P1482
P1483
P1484
Facilitator:
P1485
P1486
P1487
P1488
P1489
Facilitator:
P1490
P1491
P1492
P1493
Peptide-Based Activation of GPR116 on Alveolar Epithelial
Cells Induces G Protein-Coupled Responses and Modulates
Alveolar Surfactant Pool Sizes In Vivo/J. Bridges, A. Filuta, K.
Brown, K. Arora, A. Naren, M.-G. Ludwig, K. Seuwen, J. Jaros, W.
Miller, Cincinnati, OH, p.A5753
KLF2 Enhances Barrier Protection by Directly Regulating
RapGEF3, a GEF Which Activates Rac1/D.D.-W. Wu, R.-T.
Huang, M. Jain, A.A. Birukova, J. Lloyd, K.G. Birukov, G.M. Mutlu,
Y. Fang, Chicago, IL, p.A5754
G-CSF Promotes Alveolar Epithelial Repair Following Acute
Lung Injury/A.J. Paris, Y. Liu, N. Dai, J. Mei, K. Hudock, G.S.
Worthen, Philadelphia, PA, p.A5755
E. Roan, PhD, Memphis, TN
A Novel Cytoplasmic Domain in ENaC-Alpha Mediates
Activation by the Lectin-Like Domain of TNF/I. Czikora, Q. Yue,
A. Alli, B.J. Duke, T.L. Thai, R. Lemmens-Gruber, B. Fischer, T.
Chakraborty, W. Shabbir, D.C. Eaton, R. Lucas, Augusta, GA,
p.A5756
LPS Relocates Nuclear Resided Fbxo24 into Cytoplasmic
Compartment to Augment Histone Acetyltransferase GCN5L2
Medicated Transcriptional Activity in Lung Epithelial Cells/J. Li,
Q. Wu, C. Zou, Pittsburgh, PA, p.A5757
Examining the Collapse-Mechanism of the Pulmonary
Surfactant/M.R. Al-Saiedy, S.L. Nelson, A. Tarokh, F.H.Y. Green,
M.W. Amrein, Calgary, Canada, p.A5758
The EMT Process Occurs in Early Pulmonary Fibroproliferation
of LPS-Induced ARDS in Rats/P. Wang, M. Yu, M. Wang, B.
Zhong, J. Li, X. Zhong, P. Zhao, Q. Zhang, J. Yuan, G. Jiao,
Chengdu City, China, p.A5759
Myosin Phosphatase Protects Against LPS-Induced Pulmonary
Endothelial Barrier Dysfunction/A. Kasa, B.A. Ghorshkov, K.-M.
Kim, S. Kumar, S.M. Black, D. Fulton, C. Dimitopolou, J.D.
Catravas, A.D. Verin, Augusta, GA, p.A5760
I. Vadasz, MD, Giessen, Germany
TGF-b Promotes Ubiquitination, Endocytosis and Degradation
of the Protein Transporter Megalin in Alveolar Epithelial
Cells/L.C. Mazzocchi, C. Vohwinkel, W. Seeger, I. Vadasz,
Giessen, Germany, p.A5761
Destabilization of Lysophosphatidic Acid Receptor 1 Reduces
Cytokine Release and Protects Against Lung Injury/J. Zhao, J.
Wei, D. Su, R.K. Bowser, L. Zhang, A.M. Jacko, Y. Zhao,
Pittsburgh, PA, p.A5762
The O-Glycosylated Ectodomain of FXYD5 Impairs Alveolar
Epithelial Integrity by Inhibiting the Intercellular
Trans-Dimerization of the Na,K-ATPase/L.A. Dada, E.
Tokhtaeva, P.N. Soni, K.M. Ridge, G. Sachs, J.I. Sznajder, O.
Vagin, Chicago, IL, p.A5763
Tumor Necrosis Factor Alpha (TNF- a) Increases Strain Field
Heterogeneity in Alveolar Epithelial Cells Leading to
Monolayer Damage/J.D. Herwig, C.M. Waters, E. Roan, Memphis,
TN, p.A5764
P1494
Facilitator:
P1495
P1496
P1497
P1498
P1499
Facilitator:
P1500
P1501
P1502
P1503
P1504
Facilitator:
P1505
Hypercapnia Impairs Cell Junction Formation by Promoting
Ubiquitination and Proteasomal Degradation of the
Na,K-ATPase b-Subunit in Alveolar Epithelial Cells/V.
Kryvenko, N.M. Gabrielli, L.A. Dada, W. Seeger, J.I. Sznajder, I.
Vadasz, Giessen, Germany, p.A5765
D.W. Kamp, MD, Chicago, IL
The Effect of PGC-1a on Acute Lung Injury/J. Wang, Y. Jiao,
Chongqing City, China, p.A5766
AMP-Activated Protein Kinase and Extracellular
Signal-Regulated Kinase 1/2 Mediate Hypercapnia-Induced
Polyubiquitination and Endocytosis of ENaC in the Alveolar
Epithelium/P. Gwozdzinska, B.A. Buchbinder, W. Seeger, I.
Vadasz, Giessen, Germany, p.A5767
Exploring the Distinct Role of the Secreted Form of Nampt for
the Regulation of Pro-Survival Mechanisms in Endothelial
Cells in the Context of Acute Lung Injury/R.C. Oita, W. Ma, S.
Chiang, T. Wang, S.M. Black, J. Yuan, J.G.N. Garcia, Tucson, AZ,
p.A5768
GSK3b Stability Is Regulated by Its Activation State and
Influences Inflammation in Lung Epithelial Cells/T. Suber, J.
Cai, J. Zhao, Y. Zhao, R. Mallampalli, Pittsburgh, PA, p.A5769
The Mitochondrial Calcium Uniporter Is a Therapeutic Target in
Acute Lung Injury/M.N. Islam, G.A. Gusarova, S. Das, J.
Bhattacharya, New York, NY, p.A5770
I. Rahman, PhD, Rochester, NY
Mitochondrial OXPHOS (Complex III) Is an Important Regulator
of Fibroblast Differentiation: Implications in Bioenergetics and
Cellular Senescence/W. Lei, C.A. Lerner, I. Sundar, H. Yao, I.
Rahman, Rochester, NY, NY, p.A5771
An Antidotal Therapy for Carbon Monoxide Poisoning
Improves Survival by Reversing Hemodynamic Collapse and
Mitochondrial Dysfunction/J.J. Rose, L. Wang, Q. Xu, D.
Osei-Hwedieh, E.N. Schwoegl, Q. Nguyen, C. Corey, X.Y.N.
Huang, C.F. McTiernan, J. Tejero, C.P. O’Donnell, S. Shiva, M.T.
Gladwin, Pittsburgh, PA, p.A5772
PBMCs from Patients with Limited Systemic Sclerosis
Demonstrate Altered Mitochondrial Dynamics/S. Lenna, G.A.
Farina, H.W. Farber, R. Lafyatis, M. Trojanowska, Boston, MA,
p.A5773
Specificity of Metabolic Stress in the Regulation of
Mitochondria Dysfunction Induced mtDNA Release in Lung
Epithelial Cells/J.-S. Moon, M.J. Koo, S.W. Ryter, K. Nakahira,
A.M.K. Choi, New York, NY, p.A5774
Small Molecule Inhibition of the E3 Ligase Subunit Fbxo7
Prevents Mitochondrial Damage/Y. Liu, T. Lear, B.B. Chen, R.
Mallampalli, Pittsburgh, PA, p.A5775
H. Kubo, MD, PhD, Tokyo, Japan
Autophagy Deficient Mesenchymal Stromal Cells Are More
Susceptible to Oxidative Injury as a Result of Mitochondrial
Dysfunction/S. Ghanta, K. Tsoyi, C.A. Piantadosi, A.M.K. Choi,
M.A. Perrella, Boston, MA, p.A5776
TUESDAY MORNING
ATS 2016 • San Francisco