Final Program

56 SUNDAY • MAY 15
P749
P750
P751
P752
P753
P754
P755
Facilitator:
P756
P757
P758
P759
P760
Induction of Human Airway Epithelial to Mesenchymal
Transition (EMT) upon Human Rhinovirus Infection/D. Minor, S.
Traves, D. Proud, Calgary, Canada, p.A1473
An Exploratory Pathway Analysis of Wound-Induced Gene
Responses in Healthy and Asthmatic Human Airway Epithelial
Cells (HAEC)/H. Inoue, W. Horne, J.K. Kolls, X. Zhou, J.B.
Trudeau, S.E. Wenzel, Pittsburgh, PA, p.A1474
Clarithromycin Attenuates IL-13-Induced Goblet Cell
Hyperplasia Through SPDEF/CLCA1 Suppression in Normal
Human Bronchial Epithelial Cells/A. Nagashima, M. Shinkai, T.
Shimokawaji, M. Shinoda, K. Mishina, H. Ishii, Y. Kimura, S. Sudo,
Y. Tei, Y. Hara, T. Kodama, K. Tanaka, M. Toda, J. Tsukiji, M.
Kudo, Y. Inayama, T. Sato, M. Yamamoto, B.K. Rubin, T. Kaneko,
Yokohama, Japan, p.A1475
Mucosal Cytokines in Asthmatic Bronchoalveolar Lavage
(BAL) Fluid Reflect Systemic Inflammation and Disease
Severity/E. Hunt, S. Lapthorne, A. Sullivan, C. Ward, J. Eustace,
B. Plant, J. MacSharry, D. Murphy, Cork, Ireland, p.A1476
Transcriptomic Profiles of Bronchial Epithelial Cells in
Asthmatics Differ From Controls/N. Assad, Y. Tesfaigzi, S.A.
Ness, A. Sood, Albuquerque, NM, p.A1477
Relationship Between AirwayHyperresponsiveness to Dosed
Exercise Load and Hyperosmolar Stimuli in Patients with
Asthma/J.M. Perelman, L.G. Nakhamchen, E. Afanas’eva, A.
Prikhodko, V. Kolosov, Blagoveshchensk, Russian Federation,
p.A1478
Glucocorticoid-Driven Expression of Transcriptional
Regulators in the Human Airways/M.M. Mostafa, C.F. Rider, R.
Leigh, R. Newton, Calgary, Canada, p.A1479
R.W. Harper, MD, Sacramento, CA
The Role of Secreted HSP90a on Asthmatic Airway Epithelial
Barrier Dysfunction Induced by HDM/H. Dong, C. Huang, Y. Le,
L. Luo, Z. Xie, S. Cai, Guangzhou, China, p.A1480
Inflammatory Pattern of Bronchial Mucosa in Asthmatics with
Hyperresponsiveness to Hyposmolar Stimulus/V. Kolosov, A.B.
Pirogov, A. Prikhodko, J.M. Perelman, E. Borodin, S.V. Zinovyev,
M. Shtarberg, D. Naumov, E. Ushakova, Blagoveshchensk,
Russian Federation, p.A1481
Pseudomonas Aeruginosa Flagellin Stimulates Broad Gene
Expression in Human Airway Epithelial Cells that Is Mitigated by
Concurrent Treatment with Azithromycin/S.R. White, B. Laxman,
S. Hashemifar, B. Xie, R. Stern, N. Maltsev, Chicago, IL, p.A1482
Inhaled Corticosteroids Upregulate IL10 and GILZ in Human
Sputum-Derived Bronchial Epithelial Cells in Asthma/B. Bleck,
J.P.I. Egan, M. Cotrina-Vidal, A. Kazeros, G. Grunig, J. Reibman,
New York, NY, p.A1483
Epithelial Cells and Fibroblasts from Asthmatic and COPD
Patients Cocultures, an In Vitro Model of Asthma-COPD
Overlap Syndrome (ACOS)?/O. Le Rouzic, N. Ijiri, S. Audusseau,
C. Baglole, M.S. Ludwig, D.H. Eidelman, Q. Hamid, Montreal,
Canada, p.A1484
P761
P762
P763
P764
P765
Facilitator:
P766
P767
P768
P769
P770
P771
P772
Human ß-Defensin 1, 2 and 3 Enhance TGF-ß1-Mediated
Epithelial-Mesenchymal Transition (EMT) in Bronchial
Epithelial Cells/X.-Y. Qu, X.-M. Dang, D. Shang, W.-J. Wang, D.
Xu, Y.-P. Shao, W.-Y. Lu, Y. Chang, Xi’an, China, p.A1485
Spleen Tyrosine Kinase and Calcium Play Critical Roles in the
Release of IL-33 from Airway Epithelial Cells Exposed to
Fungus Alternaria Alternata/N. Sasaki, H. Kita, Y. Nakamura, K.
Yamauchi, Rochester, MN, p.A1486
Studying the Relationship Between Lung Inflammation and
Epithelial Cell Outside-in Barrier Permeability In Vivo/T.J.
Chapman, S. Hillman, S. Knowlden, J. Veazey, S. Georas,
Rochester, NY, p.A1487
Antisense microRNA Therapy Reduces Goblet Cell Mucousal
Metaplasia and MUC5AC Production in House Dust Mite
(HDM)-Sensitized Mice/S.C. Ramelli, J.M. McLendon, A. Ferretti,
I. Aragon, J. Fewell, R. Barringtion, W. Gerthoffer, Mobile, AL,
p.A1488
The Role of miR-141 in IL-13-Mediated Mucus Production/S.
Siddiqui, L. Zlock, D. Jun, L.R. Bonser, W. Finkbeiner, D. Erle, P.G.
Woodruff, San Francisco, CA, p.A1489
D.A. Knight, PhD, Callaghan, Australia
Potentiation of MARCKS Phosphorylation in Airway Epithelia
in Response to IL-13: Important Implications in Asthma/C.-H.
Chen, R. Li, C.-C. Lee, A.L. Linderholm, R. Harper, N.J. Kenyon, R.
Wu, Davis, CA, p.A1490
A New Role for the Bcl-2 Family of Proteins in Blocking
NF-kappaB Activation and Regulating House Dust
Mite-induced Inflammation/J.T. Jones, H.S. Chand, E.G. Awji, Y.
Mebratu, Y. Tesfaigzi, Albuquerque, NM, p.A1491
Malondialdehyde-Acetaldehyde (MAA) Adducted Surfactant
Protein Alters SRA/CD204 Gene and Protein Expression in Mouse
Lung/M. Sapkota, J.M. DeVasure, T.A. Wyatt, Omaha, NE, p.A1492
Surfactant Protein-A Promotes Resolution of Allergic
Airways/J.G. Ledford, K. Addison, D. Francisco, A.M. Pastva, J.J.
Lee, M. Kraft, Tucson, AZ, p.A1493
A Peptide Modeled After the Bik BH3 Helix Dissociates the
Bak-Bcl-2 Complex to Stabilize Bak and Reduce Allergen- and
Cigarette Smoke-Induced Mucous Cell Metaplasia in Culture
and In Vivo/Y. Mebratu, I. Leyva-Baca, E.G. Awji, M.
Delgado-Vargas, J.T. Jones, H.S. Chand, Y. Tesfaigzi,
Albuquerque, NM, p.A1494
In the Maturing Layer of Primary Human Bronchial Epithelial
Cells, Transforming Growth Factor-Beta Priming of Normal
Cells Recapitulates Delayed Jamming as Seen in Asthmatic
Cells/J.A. Mitchel, J. Notbohm, J. Butler, J.J. Fredberg, J.-A. Park,
Boston, MA, p.A1495
IL-13 Induces Periostin Production by MAP Kinase and STAT6
Phosphorylation. Inhibiting Periostin Production Modestly
Decreases MUC5AC Mucin Secretion/I. Suzaki, K. Komiya, T.
Akaba, S. Kawano, T. Tanabe, B.K. Rubin, Richmond, VA, p.A1496
ATS 2016 • San Francisco