Final Program

MONDAY • MAY 16 193
B58
THEMATIC POSTER SESSION
BIG AND BIGGER (DATA): OMICS AND
BIOMARKERS OF COPD AND OTHER CHRONIC
LUNG DISEASES
9:00 a.m. - 4:15 p.m. MOSCONE CENTER
Viewing: Posters will be on display for entire session.
Area M, Hall D (North Building, Lower Level)
Discussion: 11:00-11:45: authors will be present for individual discussion
11:45-12:45: authors will be present for discussion with assigned facilitators
P1434
P1435
P1436
P1437
P1438
P1439
P1440
P1441
P1442
P1443
Senescence-Associated MicroRNA Expression in Serum
Exsosomes and Vastus Lateralis Muscle Samples from COPD
Patients with Low and Normal Fat Free Mass Index/R. Lakhdar,
D. McGuinness, L. Monaghan, E. Drost, P. Sheils, B. MacNee, R.
Rabinovich, Edinburgh, United Kingdom, p.A4046
Identification of MicroRNAs that Potentially Regulate Chronic
Mucus Hypersecretion in COPD/H. Tasena, M. Van Den Berge, A.
Faiz, D.S. Postma, W. Timens, M. Hylkema, P.S. Hiemstra, P.J. Sterk,
I.H. Heijink, C.-A. Brandsma, Groningen, Netherlands, p.A4047
Differential Expression of microRNAs After Acute Smoke
Exposure in Primary Human Bronchial Epithelial Cells from
Smokers with and Without COPD/G.E. Holt, M. Mirsaeidi, M.
Campos, M. Salathe, Miami, FL, p.A4048
MicroRNA-218-5p Is Implicated in the Pathogenesis of Chronic
Obstructive Pulmonary Disease/G. Conickx, P. Mestdagh, F.
Avila Cobos, F.M. Verhamme, T. Maes, B.M. Vanaudenaerde, L.
Lahousse, G.F. Joos, J. Vandesompele, K.R. Bracke, G.G.
Brusselle, Ghent, Belgium, p.A4049
Effect of Electronic Cigarettes on Oxidative Stress Gene and
microRNA Expression from Lung Epithelial Cells In Vitro/S.K.
Solleti, A. Ahmad, S. Bhattacharya, Q. Wang, J. Mereness, C.
Slaunwhite, T. Rangasamy, T.J. Mariani, Rochester, NY, p.A4050
Isolation and Characterization of Extracellular Vesicles from
Plasma of Patients with Chronic Obstructive Pulmonary
Disease/I.K. Sundar, I. Rahman, Rochester, NY, p.A4052
Altered Gene Expression Profiles in Human Bronchial
Epithelial Cells Exposed to E-Cigarette Liquid: Results from a
Genome-Wide Monitoring/S. Altraja, M. Mitt, A. Altraja, Tartu,
Estonia, p.A4053
Genetic Regulation of Gene Expression Changes in COPD/C.A.
Brandsma, A. Faiz, D.S. Postma, P.D. Pare, D.D. Sin, Y. Bosse, M.
Laviolette, D.C. Nickle, K. Hao, W. Timens, M. Van Den Berge,
Groningen, Netherlands, p.A4054
Quantitative Analysis of the Soluble Proteome of Airway
Epithelial Cells in COPD/T. Heyder, M. Yang, M. Kohler, C.
Sihlbom, R. Karimi, A. Eklund, J. Grunewald, M.C. Skold, A.M.
Wheelock, Stockholm, Sweden, p.A4055
Inducible Expression Quantitative Trait Loci: A Novel Method
to Identifying Genetic Variants Associated with Corticosteroid
Responsiveness in COPD/A. Faiz, D.S. Postma, G.H. Koppelman,
P.S. Hiemstra, P.J. Sterk, W. Timens, K. Steiling, A. Spira, I.H.
Heijink, M. Van Den Berge, Groningen, Netherlands, p.A4056
P1444
P1445
P1446
P1447
P1448
P1449
P1450
P1451
P1452
P1453
P1454
Lipidomic Analysis of Human Lung Fibroblasts from
Ex-Smokers with and Without COPD/A.D. Desautels, M.H. Ryu,
T.H. Mahood, A. Jha, K. Limbert Rempel, G.L. Stelmack, R.
Chaudhary, H. Unruh, A. Ravandi, A.J. Halayko, Winnipeg,
Canada, p.A4057
Proteomic Profiling of Peripheral Exosomes Leads to the
Identification of Novel Biomarker Candidates for
Emphysema/Y. Takeda, H. Kume, K. Takafuji, H. Hirata, T. Kijima,
T. Tomonaga, A. Kumanogoh, Osaka, Japan, p.A4058
TAILS Proteomics in Two Species Identifies New Complement
Components and Protease Inhibitors as MMP-12 Substrates
During Exacerbations of COPD/B. Mallia-Millanes, A. Dufour, C.J.
Philp, C.E. Bolton, S.D. Shapiro, C.M. Overall, S.R. Johnson,
Nottingham, United Kingdom, p.A4059
Comprehensive Molecular Profiling of the Lung Using Mass
Spectrometry Based Omics Technologies/C. Ansong, G. Clair, J.
Kyle, Y.-M. Kim, S. Dautel, R. Sontag, E. Zink, J. Carson, R.
Corley, Richland, WA, p.A4060
Valosin Containing Protein Is a Novel Plasma Marker to
Indicate Cigarette Smoking Response and Chronic Obstructive
Pulmonary Disease (COPD)/C. Song, W. Chatila, T.J. Rogers,
Philadelphia, PA, p.A4061
Integration of Molecular Interactome and Targeted Interaction
Analysis to Identify a COPD Disease Network Module/A.
Sharma, M. Kitsak, M. Cho, E.K. Silverman, Boston, MA, p.A4062
Genome-Wide Association Study Identifies Novel Loci
Associated with FEV1 Decline Over 11 Years in Individuals
with Chronic Obstructive Pulmonary Disease from the Lung
Health Study/N. Fishbane, M. Obeidat, N.N. Hansel, N. Rafaels,
R.A. Mathias, I. Ruczinski, T.H. Beaty, K. Barnes, P.D. Pare, D.D.
Sin, Vancouver, Canada, p.A4063
Using Lung Gene Expression Profiles of Murine Emphysema
Models to Understand Human COPD Susceptibility/J.H. Yun, J.
Morrow, W. Qiu, T. Lao, Z. Jiang, C.A. Owen, M.A. Perrella, A.M.K.
Choi, E.K. Silverman, X. Zhou, C.P. Hersh, Boston, MA, p.A4064
Analysis of Changes in the Lung Microbiome and Host
Parameters in Current and Former Smokers with and Without
COPD in the SPIROMICS Cohort/J.R. Erb-Downward, M.K. Han,
C.M. Freeman, J.P. Brown, S. Christenson, C.B. Cooper, R.G.
Barr, N.N. Hansel, R. Kanner, M. Zeidler, W. Moore, E. Bleecker,
N. Falkowski, D. Farr, R. Paine, III, P.G. Woodruff, F.J. Martinez,
J.L. Curtis, G.B. Huffnagle, Arbor, MI, p.A4065
Association Between Blood Biomarkers, CT Phenotype and
COPD Stage in SPIROMICS/J. Taylor, I. Degtiar, S. Murray, X.
Wang, C.H. Martinez, J.R. Erb-Downward, N. Marchetti, G.J. Criner,
W.K. O'Neal, D.J. Couper, R.P. Bowler, M.B. Scholand, C. Pirozzi,
C.B. Cooper, R. Kanner, R. Paine, III, R.G. Barr, E. Bleecker, N.N.
Hansel, P.G. Woodruff, E.A. Hoffman, C. Galban, B.D. Ross, E.
Kazerooni, F.J. Martinez, M.K. Han, Ann Arbor, MI, p.A4066
Using Multiple Reaction Monitoring Mass Spectrometry to
Identify Biological Pathways and Networks Involved in COPD
Exacerbations/J. Leung, V. Chen, Z. Hollander, J.M. FitzGerald,
C. Borchers, B.M. McManus, R.T. Ng, D.D. Sin, Vancouver,
Canada, p.A4067
MONDAY MORNING
ATS 2016 • San Francisco