Final Program

340 WEDNESDAY • MAY 18
D9
BASIC • TRANSLATIONAL
SCIENTIFIC SYMPOSIUM
CME Credits Available: 2.0
CRACKING THE CELL CODE: UNDERSTANDING
THE CONTRIBUTION OF CELLS TO PULMONARY
VASCULAR DISEASES
Assemblies on Pulmonary Circulation; Respiratory Cell and Molecular
Biology
9:00 a.m. - 11:00 a.m. MOSCONE CENTER
Room 3020/3022 (West Building, Level 3)
Target Audience
Pulmonary and critical care physicians, nurse practitioners, pulmonary
vascular biologists and trainees who conduct research in diseases of the
pulmonary circulation.
Objectives
At the conclusion of this session, the participant will be able to:
• review the state of the art knowledge regarding normal development of the
pulmonary circulation and how these cellular mechanisms are recapitulated
in adult disease;
• discuss how interactions between components of the vessel wall
(endothelial cells, pericytes, fibroblasts and smooth muscle cells) serve to
respond to vascular injury and how their dysregulation can result in
disease;
• establish relevance of abnormal cell to cell interactions in the setting of
specific pulmonary vascular diseases such as pulmonary arterial
hypertension, lung fibrosis and ARDS.
As a vital part of the cardiovascular system, the pulmonary circulation is
dependent on its cell components to coordinate adequate responses in both
health and disease. While much focus has been devoted to understanding the
work of individual cells, limited attention has been given to how these cells
interact with each other to preserve the balance required for adequate gas
exchange. This symposium will summarize seminal findings regarding how cell
behavior is organized during development and how these actions are
recapitulated as part of the pulmonary vasculature’s efforts to preserve
homeostasis in response to injury and disease.
Chairing: V. De Jesus Perez, MD, Stanford, CA
K. Birukov, MD, PhD, Chicago, IL
C. Guignabert, PhD, Le Plessis Robinson, France
9:00 Development of the Pulmonary Circulation: A Blueprint for
Understanding Pulmonary Vascular Diseases
D. Greif, MD, Guilford, CT
9:20 Pulmonary Angiogenesis in Health and Disease
V. De Jesus Perez, MD, Stanford, CA
9:40 Endothelial-Pericyte Interactions in Health and Disease
C. Guignabert, PhD, Le Plessis Robinson, France
10:00 Exosomes, Microparticles in Cell-Cell Communication Within
the Pulmonary Circulation
J.R. Klinger, MD, Providence, RI
10:20 The Pulmonary Circulation Under Attack:
Endothelial-Leukocyte Communication During Lung Injury
K. Birukov, MD, PhD, Chicago, IL
10:40 Epithelial-Mesenchymal Crosstalk During Lung Tissue
Remodeling
O. Eickelberg, MD, Munchen, Germany
D10
BASIC • CLINICAL • TRANSLATIONAL
SCIENTIFIC SYMPOSIUM
CME Credits Available: 2.0
NEW CONCEPTS IN TB IMMUNITY AND TARGETS
FOR TREATMENT
Assemblies on Allergy, Immunology and Inflammation; Microbiology,
Tuberculosis and Pulmonary Infections
9:00 a.m. - 11:00 a.m. MOSCONE CENTER
Room 3016/3018 (West Building, Level 3)
Target Audience
Providers of care for tuberculosis, those with clinical and research interests in
TB drug development and immune responses, and those who research the
immune response to other intracellular pathogens and treatment of those
infections.
Objectives
At the conclusion of this session, the participant will be able to:
• learn new findings and developments about host response and
susceptibility to TB and other intracellular infections;
• apply knowledge gained from the session to new diagnostic and biomarker
strategies for patients with TB or other infections;
• utilize knowledge gained to help form new strategies for treatment or
prevention of TB and other intracellular infections.
This session will provide an update on developments in innate and acquired
immunity on tuberculosis, seeking lessons that may be gleaned from the host
responses to other intracellular pathogens. This sessions will seek cross
fertilization of knowledge of the host response between TB and non-TB
infections. The session will discuss new developments in TB biomarkers and
diagnostics, consider host susceptibilities, present TB strain differences in
pathogenicity, TB lineage and co-evolution, and conclude with therapeutic
targets for MTB treatment utilized in new treatment.
Chairing: J.J. Saukkonen, MD, Boston, MA
J.M. Keane, MD, Dublin, Ireland
A. Haczku, MD, PhD, Davis, CA
9:00 Developments in Innate Immunity of Tuberculosis
J.M. Keane, MD, Dublin, Ireland
9:20 Developments in Acquired Immunity of Tuberculosis and
Other Intracellular Pathogens
S.A. Khader, PhD, St. Louis, MO
9:40 TB Lineage, Host Response and Biomarkers
P. Nahid, MD, MPH, San Francisco, CA
10:00 New Developments in TB Diagnostics
C. Boehme, MD, Geneva, Switzerland
ATS 2016 • San Francisco