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36 SUNDAY • MAY 15<br />

9:15 Hyperpolarized Xenon-129 MRI: A New Tool to Evaluate<br />

COPD/K. Qing, Y.M. Shim, N.J. Tustison, T.A. Altes, K. Ruppert,<br />

J.F. Mata, B. Mehrad, G.W. Miller, S. Guan, I.C. Ruset, F.W.<br />

Hersman, J.P. Mugler, Charlottesville, VA, p.A1049<br />

9:30 Testing the Fletcher-Peto Assumptions Using Pulmonary<br />

Imaging Biomarker Longitudinal Measurements/R.L. Eddy, D.<br />

Pike, K. Sheikh, G. Paulin, M. Kirby, D.G. McCormack, G. Parraga,<br />

London, Canada, p.A1050<br />

9:45 Prediction of Future Lung Function Decline from Baseline<br />

Hybrid Hyperpolarized 3He MRI in Current Smokers and COPD<br />

Patients/H. Hamedani, S. Kadlecek, Y. Xin, M. Cereda, H. Gatens,<br />

J. Naji, S. Siddiqui, M. Pourfathi, M. Rossman, R.R. Rizi,<br />

Philadelphia, PA, p.A1051<br />

10:00 Regional Ventilation Defects Measured on Hyperpolarized 3He<br />

MRI Are Associated with Mucus Plugging Measured on CT in<br />

Asthma/E. Dunican, J.V. Fahy, D.G. Mummy, S. Fain, E.A.<br />

Hoffman, B.M. Elicker, D.S. Gierada, J.D. Newell, Jr, N.N. Jarjour,<br />

M. Castro, S. Nagle, San Francisco, CA, p.A1052<br />

10:15 Segmental Ventilation Defect Percentage in Hyperpolarized<br />

3He MRI in Asthma Is Associated with Airway Wall Thickness<br />

Measured on CT/D.G. Mummy, W. Zha, R. Sorkness, L.C.<br />

Denlinger, J.D. Quirk, D. Gierada, J.C. Woods, M. Castro, N.N.<br />

Jarjour, S. Fain, Madison, WI, p.A1053<br />

10:30 What Does Magnetic Resonance Imaging Signal-Intensity Mean<br />

in Asthma?/K. Sheikh, F. Guo, S. Svenningsen, A. Ouriadov, D.P.<br />

Capaldi, R.L. Eddy, D.G. McCormack, G. Parraga, London,<br />

Canada, p.A1054<br />

10:45 Measurement of Asthma Treatment Response Using<br />

Free-Breathing 1H Ventilation MRI/D.P. Capaldi, K. Sheikh, S.<br />

Svenningsen, M. Kirby, H. Coxson, D.G. McCormack, G. Parraga,<br />

London, Canada, p.A1055<br />

A21<br />

POSTER DISCUSSION SESSION<br />

CHRONIC AIRWAY INFLAMMATION: MICROBIAL<br />

INFLUENCE<br />

9:00 a.m. - 11:00 a.m. MOSCONE CENTER<br />

Room 2024 (West Building, Level 2)<br />

Poster Viewing 9:00-9:45<br />

Discussion 9:45-11:00<br />

Chairing: J.S. Deshane, PhD, Birmingham, AL<br />

M.R. Stampfli, PhD, Hamilton, Canada<br />

P.S. Foster, PhD, Callaghan, Australia<br />

S. Bozinovski, PhD, Bundoora, Australia<br />

601 The Effects of Smoking on The Lower Airway DNA Virome/B.C.<br />

Keller, G. Zhao, B.G. Wu, J.C. Clemente, L.N. Segal, St. Louis,<br />

MO, p.A1056<br />

602 Longitudinal Changes in Airway Microbiome Signatures and<br />

Immunoregulatory Cell Dynamics Following Bronchial<br />

Thermoplasty/J.S. Deshane, J. Trevor, Y. Wang, D. Zhi, M.<br />

Curtiss, F. Wang, P.G. Eipers, V.D.P. William, C. Morrow, M.T.<br />

Dransfield, Birmingham, AL, p.A1057<br />

603 A Study to Define the Microbiome of the Asthmatic Airway/E.<br />

Hunt, S. Lapthorne, C. Ward, J. Eustace, B. Plant, D. Murphy, J.<br />

MacSharry, Cork, Ireland, p.A1058<br />

604 Nasal Microbiome Composition Varies over Time in Pediatric<br />

Asthma/M. Perez-Losada, L. Alamri, A. Goldstein, K.A. Crandall,<br />

R.J. Freishtat, Ashburn, VA, p.A1059<br />

605 The Infant Gut Microbiome, Respiratory Infection, and<br />

Repeated Wheeze in the First Year of Life: Findings from the<br />

Vitamin D Antenatal Asthma Reduction Trial (VDAART)/J.E.<br />

Sordillo, Y. Zhou, M. McGeachie, N. Lange, N. Laranjo, J. Savage,<br />

V.J. Carey, E. Sodergren, S.T. Weiss, D.R. Gold, G. Weinstock,<br />

A.A. Litonjua, Boston, MA, p.A1060<br />

606 Factors Influencing the Infant Gut Microbiome at Age 3-6<br />

Months: Findings from the Ethnically Diverse Vitamin D<br />

Antenatal Asthma Reduction Trial (VDAART)/J.E. Sordillo, Y.<br />

Zhou, M. McGeachie, N. Lange, N. Laranjo, J. Savage, V.J. Carey,<br />

G. Weinstock, E. Sodergren, D.R. Gold, S.T. Weiss, A.A. Litonjua,<br />

Boston, MA, p.A1061<br />

607 Utilizing the Collaborative Cross Cohort to Identify the<br />

Genetics of Host Responses to Respiratory Syncytial<br />

Virus/A.S. Buntzman, D. Francisco, K. Addison, A. Manne, J.<br />

Frelinger, J.G. Ledford, F.D. Martinez, M. Kraft, Tucson, AZ,<br />

p.A1062<br />

608 Rhinovirus-Induced Production of PGE2 by Asthmatic<br />

Bronchial Epithelial Cells: Inverse Association with Strain<br />

Pathogenicity/L. Shi, E. Roti Roti, A. Guadarrama, P. Fichtinger,<br />

L.C. Denlinger, Madison, WI, p.A1063<br />

609 Group A Streptococcus (GAS) Indudes Bronchial Asthma<br />

(BA)/T. Matsuda, Misato-shi, Saitama, Japan, p.A1064<br />

610 Bronchial Microbiome in Severe Persistent Oral<br />

Corticosteroid-Dependent Asthma/L. Millares, G. Bermudo, M.<br />

Garcia-Nunez, C. Grimau, N. Martinez-Lopez, V. Perez-Brocal, C.<br />

Domingo, E. Monso, Sabadell, Spain, p.A1065<br />

611 Effects of Recombinant Myristoylated Rhinovirus VP4 Protein<br />

on Primary Alveolar Macrophages/J.K. Bentley, S. Jaipalli, M.<br />

Han, J. Lei, M.B. Hershenson, Ann Arbor, MI, p.A1066<br />

612 Mycobiome Analysis of Lower Airway Secretions from<br />

Children with Fungal-Sensitized Severe-Persistent<br />

Asthma/E.M. St. John Sutton, A. Tsuang, S. Viswanathan, R.<br />

Burke, D.L. Goldman, A.G. Vicencio, New York, NY, p.A1067<br />

613 Gene Expression and Protein Secretion in Normal Versus<br />

Diseased Human Lung Tissue/L. Sherman, D. Mohn, K. Miner, C.<br />

Vezina, J.A. Johnston, Thousand Oaks, CA, p.A1068<br />

614 Infants with Early Wheeze Have Decreased Lung Function and<br />

Microbial Changes of Their Upper Airway at 3 Months of Age/K.<br />

Kloepfer, S. Srivatsa, J.E. Hatch, D. Nelson, S. Janga, S.D. Davis,<br />

Indianapolis, IN, p.A1069<br />

ATS 2016 • San Francisco

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