Final Program

MONDAY • MAY 16 221
502 Characterization of a Severe Asthma Patient Population with
and Without Eosinophilic Inflammation and Frequent
Exacerbations by Multiple PROs (IDEAL)/L.M. Nelsen, R. Suruki,
F. Albers, E. Bradford, N. Gunsoy, S. Cockle, J.-Y. Shin,
Collegeville, PA, p.A4330
503 Transcriptomic Fingerprints of Fixed Airflow Limitation in Adult
Severe Asthma Patients from the U-BIOPRED Cohort/P.-P.
Hekking, M. Loza, B. De Meulder, S. Pavlidis, F. Baribaud, C. Auffray,
A.H. Wagener, P. Brinkman, D. Lefaudeux, A.T. Bansal, A.R. Sousa, J.
Corfield, E.H. Bel, I. Adcock, R. Djukanovic, K.F. Chung, P.J. Sterk,
Amsterdam, Netherlands, p.A4331
504 Dipeptidyl Peptidase-4 (DPP-4) Is a Novel Predictive Biomarker for
the Investigational Anti-IL-13 Targeted Therapy Tralokinumab/ K.
Ranade, T.-H. Pham, G. Damera, P.Z. Brohawn, F. Pilataxi, M.
Kuziora, K. Streicher, S. Manetz, I. Vainshtein, M. Liang, D. She, E.
Piper, C.E. Brightling, R.J. Martin, Gaithersburg, MD, p.A4332
505 Collective Clinical and Inflammatory Phenotyping of Asthma
and COPD by Breathomics/R. De Vries, P. Brinkman, J.W.F.
Dagelet, E. Dijkers, F.H.C. De Jongh, P.J. Sterk, Amsterdam,
Netherlands, p.A4333
506 Peripheral Blood CRTH2 Positive Cells in Patients with Severe
Asthma/L. Xue, B. Hilvering, R. Shrimanker, L. Stoeger, S. Go, C.
Borg, C. Connolly, S. Thulborm, S. Pahlke, M. Bafadhel, I. Pavord,
Oxford, United Kingdom, p.A4334
507 Predictive Performance of Non-Invasive Type 2 Biomarkers for
Asthmatic Sputum Eosinophilia in BOBCAT and U-BIOPRED
Studies/D.F. Choy, F. Cai, R.G. Knowles, R. Djukanovic, D.E.
Shaw, P.J. Sterk, K.F. Chung, I. Adcock, S.-E. Dahlen, J. Harris, J.
Matthews, J. Arron, H. Scheerens, C.T.J. Holweg, South San
Francisco, CA, p.A4335
508 The Lung Microbiota in Stable Adult Asthma Differs According
to Inflammatory Phenotype, Sex, and Atopy/G.B. Rogers, L.E.
Leong, P.G. Gibson, I.A. Yang, S.J. Hodge, P.N. Reynolds, A.L.
James, J.W. Upham, C. Jenkins, M. Peters, M. Baraket, J.L.
Simpsons, Bedford Park, Australia, p.A4336
509 Paths to ACOS: Evaluation of Persistent Airflow Limitation in
an Urban Population with Asthma/K. Doo, N. Xu, Y. Shao, M.
Liu, M.-E. Fernandez-Beros, G. Schattner, S. Garafano, L. Rogers,
G. Grunig, B. Bleck, J. Reibman, New York, NY, p.A4337
510 A Blood Eosinophil Count of Greater Than 150 Cells/uL
Predicts Sputum Eosinophilia â?¥ 3% in Patients with Severe
Asthma with Other Markers of Inflammatory Lung Disease/D.
Austin, I. Pouliquen, S. Yancey, E. Bleeker, Stockley Park, United
Kingdom, p.A4338
511 Relationship Between Th2 Gene Mean Expression in Sputum
Cells, Mast Cell Infiltration of the Airway Wall, and Airway
Hyperresponsiveness in Asthma/S. Long, Y. Lai, J.D. Nolin, M.C.
Altman, C.W. Frevert, M. Larmore, M. Peters, T.S. Hallstrand,
Seattle, WA, p.A4339
512 Analysis of T Helper Cell Gene Regulation in Asthma by
Genome-Wide Chromatin Accessibility Profiling in Monozygotic
Twins/R.N. Bauer, A.T. Satpathy, K. Qu, T. Ho, R.S. Chinthrajah,
R.L. Miller, H.Y. Chang, K.C. Nadeau, Stanford, CA, p.A4340
513 Sputum Eosinophils but not Neutrophils Are Associated with a
Very Frequent Exacerbator Phenotype in Asthma/M.T.D. Opina,
A.T. Hastie, H. Li, D.A. Meyers, E.R. Bleecker, W.C. Moore,
Winston-Salem, NC, p.A4342
514 Two IL1RL1 Asthma Risk Variants Function as Expression
Quantitative Trait Loci Through Different Promoter Usage/E.
Gordon, A. Wesolowska-Andersen, C. Urbanek, M.E.
Lachowicz-Scroggins, M. Peters, J.V. Fahy, M. Seibold, San
Francisco, CA, p.A4342
515 Circulating MicroRNAs and Association with Methacholine
PC20 in the Childhood Asthma Management Program (CAMP)
Cohort/J.S. Davis, A. Kho, K. Moore, J. Sylvia, S.T. Weiss, K.
Tantisira, Boston, MA, p.A4343
516 Novel Mechanisms of Steroid Function in Airway Smooth
Muscle Defined Through ChIP-seq/A.N. Gerber, V. Kadiyala,
R.A. Panettieri, Jr., S. Sasse, Denver, CO, p.A4344
517 A Single Dose of Inhaled Budesonide Induces Expression of
Genes Involved in Cell Signaling, Migration, Proliferation and
Anti-Inflammatory Effects in the Human Airways/R. Newton,
M.M. Mostafa, C.F. Rider, E.M. King, S. Shah, C. Dumonceaux, S.
Traves, M.M. Kelly, A. Miller-Larsson, R. Leigh, Calgary, Canada,
p.A4345
518 Clinical and Molecular Characterization of the CHI3L1/YKL-40
Severe Asthma Endotypes/J.L. Gomez, G. Crisafi, C. Holm, N.N.
Jarjour, G.A. Hawkins, D.A. Meyers, E. Bleecker, J. Reibman, L.E.
Cohn, G.L. Chupp, New Haven, CT, p.A4346
519 M1 M2 Sputum Macrophage Profiles in Healthy Individuals,
Airway Disease, Tobacco Smokers and Alternative Tobacco
Users/N.E. Alexis, H.B. Wells, S. Miller, B. Goldstein, Y. Saini, S.
Donaldson, D. Peden, Chapel Hill, NC, p.A4347
520 Day-Time Variation of Periostin in Adults With and Without
Asthma/I. Braithwaite, R. Caswell-Smith, T. Cripps, T. Charles, A.
Hosking, M. Handigol, C. Holweg, J. Matthews, M. Holliday, C.
Maillot, J. Fingleton, M. Weatherall, R. Beasley, Wellington, New
Zealand, p.A4348
521 Longitudinal Study of Serum Periostin Levels in Stable Adult
Asthma/I. Braithwaite, R.A.C. Semprini, R. Caswell-Smith, J.
Fingleton, C. Holweg, J. Matthews, M. Weatherall, R. Beasley,
Wellington, New Zealand, p.A4349
522 Polymorphisms in Duffy Antigen Receptor for Chemokines Are
Associated with Clinical Severity During Treatment Adjustment
in Asthmatics/D.G. Chapman, E.B. Mougey, K. George, J.J. Lima,
C.G. Irvin, Burlington, VT, p.A4350
523 High Blood Eosinophil Concentrations and Serum Biomarkers
of Low IL-13 Pathway Activation at Baseline Predict
Exacerbation Rate Reduction by Benralizumab for Patients
with Moderate to Severe Asthma/P. Newbold, Y. Wu, V. Shih, M.
Liang, I. Vainshtein, K. Ranade, Gaithersburg, MD, p.A4351
524 Cigarette Smoke Modifies the IL-13-Induced Th2 Gene
Signature in Primary Human Bronchial Epithelial Cells/T.C.J.
Mertens, A.M. Van Der Does, D.K. Ninaber, P.S. Hiemstra, C.
Taube, Leiden, Netherlands, p.A4352
MONDAY AFTERNOON
ATS 2016 • San Francisco