Final Program

WEDNESDAY • MAY 18 381
P919
P920
Facilitator:
P921
Alternative Splicing of the Cardiac Sodium Channel in
Pulmonary Arterial Hypertension/D. Banerjee, A. Zhou, M.
Whittenhall, I. Krishnan, A. Palmisciano, J.R. Klinger, S. Dudley,
C.E. Ventetuolo, Providence, RI, p.A7290
Increased Expression of NPY1R Mediated Increased Vascular
Reactivity to NPY/S. Crnkovic, P. Jain, B. Egemnazarov, L.M.
Marsh, B. Ghanim, W. Klepetko, P. Holzer, H. Herzog, A.
Olschewski, G. Kwapiszewska, Graz, Austria, p.A7291
S.A. Predescu, PhD, Chicago, IL
16a-Hydroxyestrone Increases Oxidative Stress Through
NADPH Oxidase 4 and Nrf2 Dysfunction Specifically in Human
Pulmonary Artery Smooth Muscle Cells/K.Y. Hood, A.P. Harvey,
M. Nilsen, A.C. Montezano, R.M. Touyz, M. MacLean, United
Kingdom, p.A7292
P922 Dynamic Mapping of Lung Vascular Development/Y. Luo, W.
Shi, Los Angeles, CA, p.A7293
P923
P924
P925
P926
P927
P928
P929
P930
P931
Intrauterine Caloric Restriction Affects the Expression of
Genes Involved in Pulmonary Endothelial Function/I.N. Zelko,
J. Roman, Louisville, KY, p.A7294
FTY720 S-Phosphonate Does Not Activate GRK2-Mediated
S1PR1 Phosphorylation and Degradation/L. Wang, R. Bittman,
S.M. Dudek, Chicago, IL, p.A7295
Structure Dependent PK Profiles of Alkyl Ester Treprostinil
Prodrugs (TPD) Administrated Via Metered Dose Inhaler to
Rats/A.J. Plaunt, R.W. Chapman, M.R. Corboz, Z. Li, W.R.
Perkins, V.S. Malinin, Bridgewater, NJ, p.A7296
The Matrikine Acetylated Proline-Glycine-Proline (AcPGP)
Couples Extracellular Matrix Fragmentation to Pulmonary
Microvascular Remodeling and Pulmonary Hypertension/G.A.
Payne, L. Viera, Y. Wu, X. Xu, R.P. Patel, A. Gaggar, C.M.
McNicholas-Bevensee, J.E. Blalock, J.M. Wells, Birmingham, AL,
p.A7297
Hyperspectral Imaging Approaches Allow Real Time 3D
Measurement of cAMP Gradients in Pulmonary Microvascular
Endothelial Cells/T. Rich, N.S. Annamdevula, R. Sweat, P.
Favreau, S. Mayes, A.L. Britain, A. Arie Nakhmani, S.J. Leavesley,
Mobile, AL, p.A7298
Simultaneous, Real Time, Measurement of 3D cAMP and Ca2+
Signals Using Hyperspectral Imaging and Analysis
Approaches/T. Rich, R. Sweat, N.S. Annamdevula, P. Favreau, S.
Mayes, K. Webb, A.L. Britain, M. Townsley, A. Nakhmani, S.J.
Leavesley, Mobile, AL, p.A7299
Differential Response to Serial Microsphere Infusions During
Creation of Canine and Porcine Models of Pulmonary
Hypertension/A. Rothman, H. Restrepo, W.N. Evans, V.
Sarukhanov, D. Mann, Las Vegas, NV, p.A7300
Heme Oxygenase-1 Is Cardioprotective Against Hyperoxia/R.R.
Bartz, H. Suliman, B. Kraft, A. Cherry, K. Welty-Wolf, J. Keenan,
C.A. Piantadosi, Durham, NC, p.A7301
Sustained Activation of RhoGTPases Promote a Synthetic
Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin
Null Mice/V. Karoor, Z. Loomis, T. Sullivan, L. Hersh, D. Irwin, E.C.
Dempsey, Aurora, CO, p.A7302
P932
Facilitator:
Lymphatics in Pleura in Normal, Malignant Pleural Effusion,
and Septic Mouse Models/Y. Tsukita, T. Okazaki, M. Kobayashi,
M. Nihei, R. Komatsu, H. Sugiura, S. Ebihara, M. Ichinose, Sendai
Miyagi, Japan, p.A7303
W.M. Kuebler, MD, PhD, Toronto, Canada
P933 Bone Morphogenetic Protein 9 Enhances Toll-Like Receptor 4
Expression and Lipopolysaccharide-Induced Leukocyte
Recruitment to the Vascular Endothelium Via Activin
Receptor-Like Kinase-2/S.L. Appleby, A. Crosby, C.G. Mitrofan,
C.M. Yates, G.B. Nash, E.R. Chilvers, N.W. Morrell, Cambridge,
United Kingdom, p.A7304
P934
P935
P936
P937
P938
P939
P940
P941
P942
P943
SMAD3 Contributes to Lung Vascular Remodeling in
Pulmonary Arterial Hypertension Via MRTF Disinhibition: A
New Pathomechanism/D. Zabini, A. Kapus, W.M. Kuebler,
Toronto, Canada, p.A7305
Bortezomib Alleviates Experimental Pulmonary Hypertension
by Regulating Intracellular Calcium Homeostasis in PASMCs/J.
Zhang, E. Wang, W. Lu, J. Wang, Guangzhou, China, p.A7306
Quercetin Induce Autophagy Via FOXO1-Depentent Pathways
and Autophagy Suppression Enhances Quercetin-Induced
Apoptosis of PASMCs in Hypoxia/H. Yuanzhou, X. Li, X. Min, Y.
Xu, L. Xiansheng, Wuhan, China, p.A7307
Therapeutic Role of Serum Response Factor (SRF) Specific
shRNA in the Treatment of Hypoxic Pulmonary Hypertension/
R. Wang, G. Sun, Anhui, China, p.A7308
Fucoidan, a Natural Polysaccharidic Ligand of P-Selectin,
Obstructs Hypoxia-Induced Pulmonary Arterial Hypertension
and Acute Lung Vasoconstriction/T. Novoyatleva, B.
Kojonazarov, A. Owczarek, W. Seeger, N. Weissmann, R.T.
Schermuly, Germany, Germany, p.A7309
Adventitial Remodeling of Experimental Pulmonary
Hypertension Induces Myofibroblast-Produced Collagen V in a
Th17-Pathways-Related Manner/A.T. Fabro, J.R. Machado, W.R.
Teodoro, A.L. Dos Santos, A.A. Dos Santos, H.R. Crunivel, P.F.
Milsoni, S.D.M. Fernezlian, A.B.G. Dos Santos, R.A. Oliveira,
M.C.R. Medeiros, C.A. Rainho, V.L. Capelozzi, Botucatu, Brazil,
p.A7310
The Regulation of Hypoxia-Inducible Factors by C-Jun
N-Terminal Protein Kinases/M. Sala, C. Chen, H.C. Do, A.V.
Misharin, G.S. Budinger, J. Liu, Chicago, IL, p.A7311
The Role of Smooth Muscle Cathepsins in Pulmonary Arterial
Hypertension Associated with Systemic Lupus Erythematosus/
H.-C. Hsu, H.-H. Li, Y.-J. Lai, Tao-Yuan, Taiwan, p.A7312
LIM-Only Protein FHL2 Suppresses Pulmonary Artery Endothelial
Cell Proliferation Through Activation of BMP Signalling/K.
Kurakula, N. Rol, J. Smits, C.M. Happe, H.J. Bogaard, P. Ten Dijke,
M.-J. Goumans, Leiden, Netherlands, p.A7313
ARDS Decreases Pulmonary Artery Compliance in a Porcine
Model/A. Santos, I. Monge-Garcia, E. Gomez Penalver, J.B.
Borges, L. Lucchetta, J. Retamal, G. Tusman, G. Hedenstierna, A.
Larsson, F. Suarez-Sipmann, Uppsala, Sweden, p.A7917
WEDNESDAY MORNING
ATS 2016 • San Francisco