Final Program

SUNDAY • MAY 15 45
916 Effect of Implementation of an Acute Pulmonary Embolism
Risk Stratification Algorithm and Educational Initiative on
Physician Behaviors and Resource Utilization/K. Klipper, J.
Thiboutot, N. Siegel, T.-T. Truong, A. Dunn, H. Poor, New York,
NY, p.A1243
917 CTEPH Associated Fibrinogen Abnormalities Among Patients
with Acute PE/B. Planquette, P. Chiles, J. Marsh, O. Sanchez, T.
Morris, Paris, France, p.A1244
918 Blood Transcriptome in Patients with Chronic
Thromboembolic Pulmonary Hypertension Differs from
Patients with Pulmonary Arterial Hypertension and Healthy
Controls/D.T. Matthews, J. West, E.D. Austin, A.R. Hemnes,
Nashville, TN, p.A1245
919 Incidence, Risk Factors and Outcomes of Upper Extremity
Deep Venous Thrombosis Among Hospitalized Patients in the
United States/G.W. Williams, S. Giri, K. Siwakoti, A. Sodhi, D.
Kadaria, Memphis, TN, p.A7768
A29
POSTER DISCUSSION SESSION
INFLAMMATION AND MECHANISMS OF AIRWAY
SMOOTH MUSCLE CONTRACTION
9:00 a.m. - 11:00 a.m. MOSCONE CENTER
Room 2014 (West Building, Level 2)
Poster Viewing 9:00-9:45
Discussion 9:45-11:00
Chairing: S.J. Gunst, PhD, Indianapolis, IN
Y.S. Prakash, MD, PhD, Rochester, MN
J.E. Bourke, PhD, Clayton, Australia
501 Pharmacologic Properties of Selective GABAA Receptor
Ligands that Relax Airway Smooth Muscle/G.T. Yocum, Y.
Zhang, G. Forkuo, M. Guthrie, A. Youmans, R. Jahan, M.R.
Stephen, D. Stafford, J. Cook, L. Arnold, C. Emala, New York, NY,
p.A1246
502 Overexpression of ORMDL3 to Upregulate SERCA2b
Correlates with Increased Airway Contractility and Ca2+
Oscillations in Airway Smooth Muscle in Precision-Cut Lung
Slices/J. Chen, M. Miller, P. Rosenthal, D. Broide, M.J. Sanderson,
Worcester, MA, p.A1247
503 Polo-Like Kinase 1 Regulates Vimentin Phosphorylation and
Airway Smooth Muscle Contraction /J. Li, R. Wang, S. Jiang,
R.A. Cleary, D.D. Tang, Albany, NY, p.A1248
504 The Actin Severing and Capping Protein Gelsolin Mediates
Airway Smooth Muscle Relaxation and Modulates Intracellular
Calcium Responses/M. Mikami, J. Danielsson, Y. Zhang, E.A.
Townsend, S. Khurana, C. Emala, New York, NY, p.A1249
505 TNFa Increases Airway Smooth Muscle Force Generation
Through Changes in Actin and Myosin Remodeling/M. Dogan,
P. Delmotte, Y.-S. Han, G.C. Sieck, Rochester, MN, p.A1250
506 Comparison of the Pharmacological Profile of Long-Acting
Muscarinic Antagonists on Isolated Human Bronchi/E. Naline,
S. Grassin Delyle, H. Salvator, P. Devillier, Suresnes, France,
p.A1251
507 Inflammation Increases Mitochondria Fragmentation,
Mitochondria Volume Density and Oxygen Consumption Rate
in Human Airway Smooth Muscle/P. Delmotte, M. Dogan, Y.S.
Prakash, G.C. Sieck, Rochester, MN, p.A1252
508 Intrapulmonary Airway Smooth Muscle Contractile Properties
Are Not Intrinsically Altered in Cystic Fibrosis and Asthma/G.
Ijpma, O. Matusovsky, L. Kachmar, A. Panariti, J.G. Martin, A.-M.
Lauzon, Montreal, Canada, p.A1253
509 Naringin as Natural Fruit Product and Bitter Taste Agonist
Induces Relaxation of Airway Smooth Muscle Cells Via
Intracellular Calcium Signaling/L. Deng, Y. Lu, Y. Wang, M. Luo,
X. Shi, Y. Pan, Changzhou, China, p.A1254
510 Serelaxin Is a Novel Potent Bronchodilator in Rat Precision
Cut Lung Slices (PCLS) and Trachea/J.E. Bourke, S.G. Royce,
C. Donovan, M. Jelinic, L. Parry, C. Samuel, M. Lam, Clayton,
Australia, p.A1255
511 The Impact of Bronchial Thermoplasty on Airway Epithelial
and Smooth Muscle Cells: An In Vitro and In Silico Study/B.S.
Brook, I.L. Chernyavsky, G.E. Morris, R.M. Saunders, F.R.A.J.
Rose, O.E. Jensen, C.E. Brightling, Nottingham, United Kingdom,
p.A1256
512 Modulation of Mitochondrial Dynamics and Functions in
Human Airway Smooth Muscle Cells by Bitter Taste Receptor
Agonists/S. Pan, B. Tiegs, D.A. Deshpande, Philadelphia, PA,
p.A1257
513 Analysis of the Splicing Regulation of the Smooth Muscle
Myosin Heavy Chain Fast Contracting Isoform/M. Issouf, A.
Vargas, St-Hyacinthe, Canada, p.A1258
514 Serine Phosphorylation of Non-Muscle Myosin II Heavy Chain
Regulates the Contraction of Airway Smooth Muscle (ASM) by
Regulating the Assembly of Adhesion Junction Signaling
Complexes/W. Zhang, S.J. Gunst, Indianapolis, IN, p.A1259
515 A Narrow Spectrum Kinase Inhibitor, RV1729, Induces
Bronchodilation of Human Small Airways and Rescues
Agonist-Induced Desensitization of the b2 Adrenoreceptor
(b2AR)/C.J. Koziol-White, J. Zhang, E. Yoo, C. Charron, C.
Stevenson, R.A. Panettieri, Philadelphia, PA, p.A1260
516 Cigarette Smoke Influences Cellular Metabolic Signaling by
Deregulating Mitochondrial Morphology and Function in
Human Airway Smooth Muscle/B. Aravamudan, M.A. Thompson,
C. Pabelick, G.C. Sieck, R. Vassallo, Y.S. Prakash, Rochester, MN,
p.A1261
517 Obesity -Related Airway Hyperresponsiveness Is Regulated by
Endothelin-1 in Mice/D.I. Kasahara, N.G. Verbout, T.A. Brown, Y.
Cho, S.A. Shore, Boston, MA, p.A1262
518 Inhaled Simvastatin Concomitantly Prevents Generation of
Oxidized Phosphatidylcholine, Airway Inflammation, and
Hyperresponsiveness in Allergen-Challenged Mice/A. Jha, M.H.
Ryu, R. Chaudhry, A. Ravandi, A.J. Halayko, J. Schwartz, S. Basu,
Winnipeg, Canada, p.A1263
SUNDAY MORNING
ATS 2016 • San Francisco