Final Program

SUNDAY • MAY 15 35
9:15 Polymorphisms of Genes Involved in Extracellular Matrix
Remodeling and Bronchopulmonary Dysplasia in Extremely
Low Birth Weight Infants/U. Paudel, A. Amin, L.A. Parton,
Valhalla, NY, p.A1034
9:30 Early ‘OMIC’ Biomarkers Predict Bronchopulmonary Dysplasia
(BPD)/C.V. Lal, V. Bhandari, N. Ambalavanan, Birmingham, AL,
p.A1035
9:45 Genetic Ancestry and Genome-Wide Associations Related to
Bronchopulmonary Dysplasia in Preterm Infants Treated with
Inhaled Nitric Oxide (iNO)/D.G. Torgerson, S. Oh, R.L. Keller, S.
Huntsman, D. Hu, C. Eng, D. Black, E.G. Burchard, P.L. Ballard,
R.A. Ballard, San Francisco, CA, p.A1036
10:00 A Multi-Omics Approach to Identify Genes Associated with
Childhood Asthma Risk and Morbidity/E. Forno, Q. Yan, T.
Wang, E. Acosta-Perez, A. Colon-Semidey, M. Alvarez, N.
Boutaoui, J.F. Alcorn, G. Canino, W. Chen, J.C. Celedon,
Pittsburgh, PA, p.A1037
10:15 Gene Expression Reflective of Type 2 Inflammation in the
Upper and Lower Airways of Children with Asthma in the
Severe Asthma Research Program (SARP)/A. Coverstone, L.B.
Bacharier, M. Peters, A.M. Fitzpatrick, W.G. Teague, B. Gaston, W.
Phipatanakul, N. Ly, S. Ramratnam, J.V. Fahy, A.T. Hastie, P.G.
Woodruff, S.C. Kerr, D. Mauger, B. Phillips, S.E. Wenzel, M.
Castro, St. Louis, MO, p.A1038
10:30 Mitotic Asynchrony Induces a Pro-Inflammatory State in
Airway Epithelium/S. Alcala, A. Benton, A. Watson, E. Reeves, J.
Damsker, Z. Wang, K. Nagaraju, M.C. Rose, E.P. Hoffman, R.J.
Freishtat, Washington, DC, p.A1039
10:45 Gene Therapy for Spinal Muscular Atrophy Type 1 Improves
Survival and Stabilizes Pulmonary Outcomes in a Phase I/IIa
Safety Study/R.D. Shell, K. Kotha, S. Al-Zaidy, W.D. Arnold, L.
Rodino-Klapac, J. Kissel, S. McElroy, C. Miranda, L. Lowes, L.
Alfano, K. Berry, S. Corcoran, K. Meyer, S. Likhite, B. Kaspar, J.
Mendell, Columbus, OH, p.A1040
9:15 Potassium Channel Subfamily K Member 3 (KCNK3)
Contributes to the Development of Pulmonary Arterial
Hypertension/F. Antigny, A. Hautefort, J. Meloche, M.
Belacel-Ouary, B. Manoury, F. Potus, C. Rucker-Martin, V. Nadeau,
G. Ruffenach, E. Tremblay, A. Bourgeois, B. Ranchoux, S.
Breuil-Bonnet, P. Dorfmuller, E. Fadel, P. Jourdon, B. Girerd, D.
Montani, S. Provencher, S. Bonnet, M. Humbert, F. Perros, Le
Plessis Robinson, France, p.A1042
9:30 PPARg Controls the DNA Damage Response by Modulating
UBR5 Interaction with the MRE11-RAD50-NBS1 Complex, an
Impaired Signalling Pathway in Pulmonary Arterial
Hypertension/C.G. Li, C.S. Mahon, E. Verschueren, V. Kantamani,
N. Sweeney, I. Diebold, S. Sa, L. Wang, A. Cao, J.K. Hennigs, K.
Cimprich, M. Rabinovitch, Stanford, CA, p.A1043
9:45 Loss of Cavin-2 Contributes to Lung Caveolae Dysfunction
Enhancing Pulmonary Arterial Hypertension/B.J. Dunmore, A.
Crosby, S. Moore, J. Cheng, G. Howard, M. Southwood, B.J.
Nichols, N.W. Morrell, Cambridge, United Kingdom, p.A1044
10:00 LPS-Induced Acute Lung Inflammation, Cav-1 Degradation,
and eNOS Uncoupling Is Associated with Endothelial
Dysfunction and Pulmonary Vascular Remodeling/S.D.S.
Oliveira, M. Castellon, J.W. Chen, R.F. Machado, M.G. Bonini,
M.H. Elliot, R.D. Minshall, Chicago, IL, p.A1045
10:15 Intracellular MIF Contributes to the Abnormal
Hyper-Proliferative and Apoptosis-Resistant Phenotype in
iPAH Endothelial Cells Via a p53/PTEN Dependent
Mechanism/M. Le Hiress, L. Tu, C. Phan, R. Thuillet, A. Seferian,
E.-M. Jutant, E. Fadel, G. Simonneau, Y. Tamura, A. Huertas, M.
Humbert, C. Guignabert, Le Plessis-Robinson, France, p.A1046
10:30 BMPR2 Augmented EPC Delivery in a Rat Monocrotaline
Induced PAH Model Alters Smad Signalling Profiles/R.L. Harper,
R. Ward, C. Bonder, P.N. Reynolds, Adelaide, Australia, p.A1047
Featured Speaker
10:45 Genetics in PAH: 2016 and Beyond/N.W. Morrell, MD,
Cambridge, United Kingdom,
SUNDAY MORNING
A18
MINI SYMPOSIUM
BLINDED BY THE LIGHT: INSIGHT FROM
GENETICS IN PAH
9:00 a.m. - 11:00 a.m. MOSCONE CENTER
Room 3016/3018 (West Building, Level 3)
Chairing: M. Aldred, PhD, Cleveland, OH
N.W. Morrell, MD, Cambridge, United Kingdom
Oral Presentations
9:00 Pre-Capillary Specific Pulmonary Vascular Smooth Muscle Cell
Growth Via Altered BMP Signaling in Idiopathic Pulmonary
Arterial Hypertension (IPAH)/K. Ihida-Stansbury, H. Li, M.
Chokshi, T. Nguyen, R. Riley, S.M. Kawut, H. DeLisser,
Philadelphia, PA, p.A1041
A19
MINI SYMPOSIUM
GETTING POLARIZED: MR IMAGING IN
OBSTRUCTIVE LUNG DISEASE
9:00 a.m. - 11:00 a.m. MOSCONE CENTER
Chairing: J.C. Woods, PhD, Cincinnati, OH
S.B. Fain, PhD, Madison, WI
Oral Presentations
Room 2020/2022 (West Building, Level 2)
9:00 Characterizing the Ventilation Distribution in Healthy Normal
Subjects to Establish Robust Quantitative Analysis of 129Xe
MRI/M. He, S.H. Robertson, J.M. Wang, L.G. Que, K. Mahmood, B.
Driehuys, Y.-C. Huang, Durham, NC, p.A1048
ATS 2016 • San Francisco