Final Program

92 SUNDAY • MAY 15
P377
P378
P379
P380
Facilitator:
P381
P382
P383
P384
Attenuation of EC-SOD Gene Expression in Aging Lung
Fibroblasts: Role of Histone Acetylation/I.N. Zelko, J.D.
Ritzenthaler, S. Barve, S. Ghare, J. Roman, Louisville, KY, p.A2328
AMPK Activators Reduces Cigarette Smoke-Induced
Inflammatory Responses and Elastase-Induced Mouse
Emphysema/Y.-Y. Li, C. Huang, J. Li, H.-W. Yao, Hefei, China,
p.A2329
Targeting the mTOR Signaling Pathway to Inhibit Lung Cell
Senescence in Chronic Obstructive Pulmonary Disease
(COPD)/A. Houssaini, K. Kebe, M. Breau, E. Marcos, J. Huang, A.
Attwe, E. Bizard, S. Abid, P. Validire, B. Maitre, S. Meiners, V.
Amsellem, S. Adnot, Creteil, France, p.A2330
Mitochondrial Uncoupling Protein UCP2 Regulates
Aging-Related Experimental Lung Fibrosis/S. Rangarajan, D.
Kurundkar, A. Kurundkar, M.L. Locy, K. Bernard, J. Deshane, V.J.
Thannickal, Birmingham, AL, p.A2331
R.J. Freishtat, MD, MPH, Washington, DC
Regenerative Asynchrony Is a Driver in Chronic Inflammation
in Aging/C.E. Hoptay, S. Alcala, E.P. Hoffman, R.J. Freishtat,
Washington, DC, p.A2332
Telomerase-Dependent Modulation of Small Airway
Remodeling in Chronic Obstructive Pulmonary Disease/A.J.F.
Tiendrebeogo, M. Dagouassat, F. Schlemmer, J. Tran Van Nhieu,
P. Caramelle, A. Samb, J. Boczkowski, S. Lanone, Creteil, France,
p.A2333
Cigarette Smoke Exposure- and Aging- Impair Autophagy that
Mediates COPD-Emphysema Pathogenesis/N. Vij, P.
Chandramani, C.V. Westphal, R. Hole, T. Min, M. Bodas, Mt.
Pleasant, MI, p.A2334
The Role of ER Stress in Aging In Vitro and In Vivo Models of
Ventilator Induced Lung Injury/J.A. Herbert, M.S. Valentine, J.
Nkwocha, F.K. Gninzeko, R. Singh, P. Patel, A.A. Fowler, A.
Reynolds, R. Pidaparti, R.L. Heise, Richmond, VA, p.A2335
P385 Involvement of Lamin B1 in COPD Pathogenesis/N. Saito, J.
Araya, S. Ito, T. Kadota, M. Yoshida, N. Sato, K. Tsubouchi, Y.
Kurita, K. Kobayashi, S. Minagawa, H. Hara, H. Utsumi, H.
Yanagisawa, M. Hashimoto, H. Wakui, J. Kojima, T. Numata, Y.
Kaneko, T. Morikawa, K. Nakayama, K. Kuwano, Tokyo, Japan,
p.A2336
Facilitator:
P386
P387
P388
L.M. Schnapp, MD, Charleston, SC
Aging Is Not Enough!: Bleomycin-Induced Fibrosis in an
Accelerated Aging Mouse Model/J. Calyeca, R. Olmos, R. Jasso,
M. Gaxiola, C. Lopez-Otin, M. Selman, A. Pardo, Mexico City,
Mexico, p.A2337
Biological Aging of the Idiopathic Pulmonary Fibrosis
Lung/J.E. McDonough, D.S. Martens, S. Verleden, G.M. Verleden,
N. Kaminski, J.C. Hogg, T.S. Nawrot, B.M. Vanaudenaerde, W.
Wuyts, Leuven, Belgium, p.A2338
Analysis of the Telomerase Activity of Alveolar Cells in
COPD/M. Ueno, T. Maeno, H. Masubuchi, K. Yamaguchi, K. Hara,
M. Sato, N. Harada, Y. Shimizu, M. Motegi, T. Suga, M.
Kurabayashi, Takasaki, Gunma, Japan, p.A2339
P389
P390
A71
Telomere Shortening and Progression in Patients with Chronic
Obstructive Pulmonary Disease (COPD)/E. Cordoba-Lanus, A.
Espinoza-Jimenez, R. Baz-Davila, S. Cazorla, A.
Montejo-de-Garcini, A. Aguirre-Jaime, B. Celli, C. Casanova, Santa
Cruz de Tenerife, Spain, p.A2340
HIV Infection Promotes Lung Cellular Senescence/S.
Stephenson, Y.-H. Chow, C. Wilson, K.A. Crothers, I. Petrache,
L.M. Schnapp, Charleston, SC, p.A2341
EPIGENETICS
THEMATIC POSTER SESSION
9:00 a.m. - 4:15 p.m. MOSCONE CENTER
Viewing: Posters will be on display for entire session.
Area D, Hall D (North Building, Lower Level)
Discussion: 11:00-11:45: authors will be present for individual discussion
11:45-12:45: authors will be present for discussion with assigned facilitators
P392
P393
P394
P395
P396
P397
P398
P399
Next-Generation Sequencing Identifies DNA Methylation of the
Dhx58/LGP2 Locus as a Candidate Pathway Limiting Regulatory
T Cell-Mediated Acute Lung Injury Resolution/B.D. Singer, S.
Yegnasubramanian, F.R. D’Alessio, Chicago, IL, p.A2342
In Utero Epigenetic Programming and Asthma
Pathogenesis/W.W.-Y. Tang, N. Limjunyawong, T. Dao, B.H.-Y.
Yeung, W. Mitzner, Baltimore, MD, p.A2343
Dynamic Changes of DNA Methylation During Different Stages
of Normal Mouse Lung Development/C.R. Espinoza, D. Chhabra,
T. Nicola, N. Ambalavanan, N. Kaminski, E. Sefer, Z. Bar-Joseph,
J.S. Hagood, La Jolla, CA, p.A2344
Primary Human Bronchial Epithelial Cells (HBECs) Isolated
from Smokers Have Epigenetically Impaired Antiviral Innate
Immune Response/W. Wu, W. Zhang, J.L. Booth, X. Wang, J.P.
Metcalf, Oklahoma City, OK, p.A2345
Single Cell Sequencing Characterization of the Human Small
Airway Epithelium Club (“Clara”) Cell Transcriptome/W.-L. Zuo,
L. Sheng, P. Vijay, C. Mason, R.J. Kaner, S. O’Beirne, M. Staudt,
R.G. Crystal, New York, NY, p.A2346
Gene-Based Segregation Analysis in Whole Exome Sequencing
Studies/D. Qiao, C. Lange, J.D. Crapo, T.H. Beaty, N.M. Laird, S.
Won, E.K. Silverman, M.H. Cho, Boston, MA, p.A2347
Mining the Exome Chip for Genetic Variants Associated with
Body Mass Index (BMI) and Pectoralis Muscle Index (PMI) in
COPDGene COPD Cases and Controls/M.-L. McDonald, A.A.
Diaz, J.C. Ross, R.S.J. Estepar, B.D. Hobbs, M.M. Parker, E.S.
Wan, E.A. Regan, E. Eckbo, N. Muralidhar, C.E. Come, C.P.
Hersh, R. Casaburi, J. Hokanson, T.H. Beaty, M.H. Cho, E.K.
Silverman, G. Washko, D.L. DeMeo, Boston, MA, p.A2348
The Relationship Between Exome Chip Variants and Resting
Blood Oxygenation in COPD/M.-L. McDonald, B.D. Hobbs, M.M.
Parker, P.J. Castaldi, R. Casaburi, J.M. Wells, S.M. Lutz, E.A.
Regan, B.J. Make, J. Hokanson, J.D. Crapo, T.H. Beaty, M.H. Cho,
E.K. Silverman, C.P. Hersh, Boston, MA, p.A2349
ATS 2016 • San Francisco