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SUNDAY • MAY 15 119<br />

A97<br />

MINI SYMPOSIUM<br />

ROLE OF AGING ON THE DEVELOPMENT OF LUNG<br />

DISEASE(S)<br />

2:15 p.m. - 4:15 p.m. MOSCONE CENTER<br />

Chairing: V.J. Thannickal, MD, Birmingham, AL<br />

A.L. Mora, MD, Pittsburgh, PA<br />

C.J. Le Saux, PhD, San Antonio, TX<br />

Featured Speaker<br />

Room 2020/2022 (West Building, Level 2)<br />

2:15 Macrophage Heterogeneity in the Aging Lung/G.R.S. Budinger,<br />

MD, Chicago, IL,<br />

Oral Presentations<br />

2:30 Transcriptional Profiling Reveals an Aging Signature that<br />

Persists During Influenza Infection/P.A. Reyfman, S. Berdnikovs,<br />

A.C. Mc Quattie-Pimentel, F.J. Gonzalez-Gonzalez, M. Chi, N.<br />

Chandel, H.R. Perlman, K.M. Ridge, W.E. Balch, R.I. Morimoto, J.I.<br />

Sznajder, G.S. Budinger, A.V. Misharin, Chicago, IL, p.A2626<br />

2:45 Accelerated Lung Aging in COPD: A Lung Tissue Gene<br />

Expression Signature/M. De Vries, A. Faiz, D.S. Postma, D.D.<br />

Sin, Y. Bosse, D.C. Nickle, W. Timens, M. Van Den Berge, C.A.<br />

Brandsma, Groningen, Netherlands, p.A2627<br />

3:00 Role of p16(Ink4a) in Cigarette Smoke-Induced Lung<br />

Senescence/I.K. Sundar, C.A. Lerner, J. Gerloff, H. Yao, I.<br />

Rahman, Rochester, NY, p.A2628<br />

3:15 Altered Mitochondrial Dynamics and Function in Aged Airway<br />

Smooth Muscle/S. Pan, P. Sharma, D.A. Deshpande,<br />

Philadelphia, PA, p.A2629<br />

3:30 Nox4 Mediates Age-Associated Endothelial Barrier Dysfunction<br />

and Acute Lung Injury Severity/L. Hecker, T. Wang, T. Zhou, Y.-J.<br />

Shin, S. Palumbo, J.G.N. Garcia, Tucson, AZ, p.A2630<br />

3:45 Histone Modification H4K16 Acetylation Regulates Pro-Fibrotic<br />

Gene Expression in IPF Lung Fibroblasts and in an Aging<br />

Model of Persistent Lung Fibrosis/Y. Sanders, H. Liu, V.J.<br />

Thannickal, Birmingham, AL, p.A2631<br />

4:00 Aging and ER Stress Regulates Mitochondrial Homeostasis in<br />

Lung Epithelial Cells: ATF3 Regulates PINK1 Transcription./M.<br />

Bueno, J. Brands, R. Mallampalli, A.L. Mora, Pittsburgh, PA, p.A2632<br />

A98<br />

MINI SYMPOSIUM<br />

DOES THIS MEAN I HAVE TO WEAR THAT MASK?<br />

NON PAP THERAPIES FOR SDB<br />

2:15 p.m. - 4:15 p.m. MOSCONE CENTER<br />

Room 2006/2008 (West Building, Level 2)<br />

Chairing: R.J. Schwab, MD, Philadelphia, PA<br />

D.J. Eckert, PhD, Sydney, Australia<br />

F.R. Almeida, DDS, MSc, PhD, Vancouver, Canada<br />

Oral Presentations<br />

2:15 Comparative Efficacy of Continuous Positive Airway Pressure,<br />

Mandibular Advancement Devices, Dietary Weight Loss and<br />

Exercise Training in the Treatment of Obstructive Sleep<br />

Apnea: A Network Meta-Analysis/I.H. Iftikhar, L. Bittencourt, S.D.<br />

Youngstedt, N. Ayas, P.A. Cistulli, R.J. Schwab, M. Durkin, U.J.<br />

Magalang, Columbus, OH, p.A2633<br />

2:30 Effects of Oral Appliance Therapy on the Phenotypic Causes<br />

of Obstructive Sleep Apnea/B.A. Edwards, C. Andara, S.A.<br />

Sands, S.A. Joosten, S. Landry, R.L. Owens, D.P. White, G.<br />

Hamilton, A. Wellman, Melbourne, Australia, p.A2634<br />

2:45 Multimodal Phenotyping for Prediction of Oral Appliance<br />

Treatment Outcome in Obstructive Sleep Apnea/K. Sutherland,<br />

A. Chan, J. Ngiam, O. Dalci, A. Darendeliler, P.A. Cistulli, Sydney,<br />

Australia, p.A2635<br />

3:00 Predicting Pharyngeal Collapsibility (Pcrit) Using<br />

Polysomnographic and Anthropometric Indices/P. Genta, F.<br />

Schorr, B.A. Edwards, A. Wellman, G. Lorenzi-Filho, Sao Paulo,<br />

Brazil, p.A2636<br />

3:15 Desipramine Reduces Upper Airway Collapsibility and<br />

Improves Obstructive Sleep Apnea in Selected Patients/L.<br />

Taranto Montemurro, S.A. Sands, B.A. Edwards, M. Marques, A.<br />

Azarbarzin, D.P. White, A. Wellman, Boston, MA, p.A2637<br />

3:30 Effects of Electrode Placement on Tongue Movement in Upper<br />

Airway Stimulation Therapy/S.H.C. Wang, J. Verbraecken, J.W.<br />

De Backer, W. De Backer, P. Van De Heyning, Q. Ni, B.T. Keenan,<br />

O.M. Vanderveken, R.J. Schwab, Philadelphia, PA, p.A2638<br />

3:45 Effect of Electrical Stimulation of the Calf Muscle to Reduce<br />

Seated Leg Fluid Accumulation and Rostral Fluid Shift While<br />

Supine/D. Vena, J. Rubianto, Y. Qorashi, M.R. Popovic, A.<br />

Yadollahi, Toronto, Canada, p.A2639<br />

Featured Speaker<br />

4:00 Disentangling the Traits: Role of Phenotyping in Developing New<br />

Treatment for Sleep Apnea/D.A. Wellman, MD, PhD, Boston, MA<br />

A101<br />

POSTER DISCUSSION SESSION<br />

HOST DEFENSE, LUNG INJURY, AND FIBROSIS:<br />

INNATE MECHANISMS<br />

2:15 p.m. - 4:15 p.m. MOSCONE CENTER<br />

Room 133 (North Building, Lower Level)<br />

Poster Viewing 2:15-3:00<br />

Discussion 3:00-4:15<br />

Chairing: A. Rogers, MD, MPH, Palo Alto, CA<br />

M.T. Borchers, PhD, Cincinnati, OH<br />

C.S. Dela Cruz, MD, PhD, New Haven, CT<br />

101 Pirfenidone Exacerbates Granulomatous Inflammation and<br />

Disease Progression in Tuberculosis/W. Bishai, B.A. Ahidjo, M.<br />

Maiga, A.A. Ordonez, L.S. Cheung, S. Beck, B. Andrade, M. Klunk,<br />

S. Jain, Baltimore, MD, p.A2640<br />

SUNDAY AFTERNOON<br />

ATS 2016 • San Francisco

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