Final Program

WEDNESDAY • MAY 18 351
1011 The Role of the Bone Morphogenetic Protein 9 in Endothelial
Inflammation/C.G. Mitrofan, S. Appebly, N. Morrell, Cambridge,
United Kingdom, p.A6589
1012 The NF-kB Pathway Is Important for Phenotype and
Proliferation of Pulmonary Microvascular Endothelial Cells and
Lung Endothelial Progenitor Cells/D. Farkas, V. Kraskauskiene,
A.A. Fowler, K. Islam, R. Natarajan, L. Farkas, Richmond, VA,
p.A6590
1013 Autocrine Regulation of Interleukin 33 Expression in Human
Pulmonary Artery Endothelial Cells/T.C. Tsui, S. Boeder, E.C.
Breen, T.D. Bigby, La Jolla, CA, p.A6591
1014 TNFa Stimulates an Inflammatory Response in Human
Pulmonary Microvascular Endothelial Cells (HPMECs): The
Role of NF-kB and BET Proteins/A. Natsuki, J. Wort, F. Chung,
I.M. Adcock, S. Mumby, London, United Kingdom, p.A6592
D27
POSTER DISCUSSION SESSION
MACROPHAGES: RESOLVERS, RESPONDERS OR
BOTH?
9:00 a.m. - 11:00 a.m. MOSCONE CENTER
Room 2014 (West Building, Level 2)
Poster Viewing 9:00-9:45
Discussion 9:45-11:00
501 Requirement of IL-6 for Maximal M2 Macrophage
Accumulation, and Growth of Ectopically Delivered B16
Melanoma, in Mouse Lungs Upon Oncostatin M
Overexpression/L. Izakelian, E. Ayaub, A. Dubey, S. Wong, F.
Botelho, K. Ask, C.D. Richards, Hamilton, Canada, p.A6593
502 Tumor-Associated Macrophages Induces Activation of STAT3
on Small Cell Lung Cancer Cells/T. Iriki, K. Ohnishi, Y.
Komohara, Y. Fujiwara, M. Takeya, H. Kohrogi, Kumamoto, Japan,
p.A6594
503 Modulation of Alveolar Macrophage Immune Function by Fatty
Acid Ethyl Esters/T.W. Gauthier, X.D. Ping, L.A.S. Brown, Atlanta,
GA, p.A6595
504 Tissue-Resident Alveolar Macrophages Persist Over the
Lifespan with Minimal Input from the Bone Marrow but Are
Replaced by Monocyte-Derived Cells Upon Depletion/A.C. Mc
Quattie-Pimentel, F.J. Gonzalez, C.-I. Chen, J.M. Walter, M. Chi, S.
Soberanes, R. Piseaux, K.M. Ridge, H.R. Perlman, G.S. Budinger,
A.V. Misharin, Chicago, IL, p.A6596
505 Apoptosis Signal Regulating Kinase-1 Promotes
Inflammasome Priming in Alveolar Macrophages/J.A. Kennedy,
C.N. Immanuel, C. Luellen, B. Teng, E.A. Fitzpatrick, C.M. Waters,
Memphis, TN, p.A6597
506 Pulmonary Alveolar Proteinosis Is Driven by Reduced
GM-CSF-Dependent Cholesterol Clearance by Alveolar
Macrophages, Not an Inability to Catabolize Surfactant
Phospholipids/A. Sallese, T. Suzuki, J. Bridges, A. Filuta, D.
Black, C. Chalk, B. Carey, B.C. Trapnell, Cincinnati, OH, p.A6598
507 TGFb1 Induced Mammalian Lung Fibrosis Requires TGFBR2
Expression on Macrophages/X. Peng, R. Homer, J.A. Elias, E.
Herzog, New Haven, CT, p.A6599
508 Alveolar Macrophage Activation Pattern in Idiopathic
Pulmonary Fibrosis (IPF): Bronchoalveolar Lavage (BAL)
Transcriptome Analysis/C.M. Swaisgood, I. Arisi, F. Mariani, E.
Puxeddu, M. Amicosante, D. Giovannini, M. Pallante, G. Paone, T.
Flagg, M.L. Brantly, C. Saltini, Gainesville, FL, p.A6600
509 Macrophage Mitochondrial Calcium Content Is Required for
Pulmonary Fibrosis Development/L. Gu, A.J. Ryan, J.L.
Larson-Casey, A.B. Carter, Birmingham, AL, p.A6601
510 IL-6 Mediated Hyperpolarization of Profibrotic Macrophages Is
Dependent on Spliced XBP1/E. Ayaub, K. Tandon, P.
Parthasarathy, J. Murphy, P.S. Kolb, S. Lhotak, M.R.J. Kolb, M.D.
Inman, R.C. Austin, C.D. Richards, K. Ask, Hamilton, Canada,
p.A6602
511 A Unique Human Alveolar Macrophage Polarization Phenotype
Is Associated with Disease Progression in Idiopathic
Pulmonary Fibrosis/L.M. Nicol, M. Brittan, J.A. Marwick, A.C.
MacKinnon, R. Mills, P.A. McFarlane, W.A. Wallace, G. Stewart, J.
Simpson, A.G. Rossi, S.E. Howie, J.T. Murchison, N. Hirani,
Edinburgh, United Kingdom, p.A6603
512 Transcriptional Signatures of Alveolar Macrophages in a
Murine Model of Chronic Granulomatous Disease: Similarities
to Sarcoidosis/A. Mohan, S.A. Gharib, A. Malur, M. McPeek, B.P.
Barna, L.M. Schnapp, M.J. Thomassen, Greenville, NC, p.A6604
513 Expression of CD71 on Alveolar Macrophages Reveals Distinct
Cell Populations in Human Bronchoalveolar Lavage from
Patients with Interstitial Lung Disease/S.J. Allden, R.J. Toshner,
A.J. Byrne, C.M. Lloyd, T. Maher, Slough, United Kingdom,
p.A6605
514 Hypercapnia Increases Mortality of Influenza A Virus Infection
in Mice and Viral Replication in Macrophages by a RIG-1- and
MDA5-dependent Mechanism/M. Casalino Matsuda, A. Nair, M.
Chi, K.L. Gates, G.S. Budinger, P.H. Sporn, Chicago, IL, p.A6606
515 Mitochondrial Transfer Via Tunnelling Nanotubes (TNT) Is a
Novel Mechanism by Which Mesenchymal Stromal Cells
Enhance Macrophage Phagocytosis in In Vivo Models of Acute
Lung Injury/M.V. Jackson, T.J. Morrison, D.F. McAuley, M.
Matthay, C.M. O’Kane, A.D. Krasnodembskaya, Belfast, United
Kingdom, p.A6607
516 Monocyte-Derived Alveolar Macrophages Contribute to the
Development of Lung Fibrosis and Persist in the Lung Over
the Lifespan/A.V. Misharin, L. Morales-Nebreda, C.M. Cuda, P.A.
Reyfman, S. Berdnikovs, A.C. McQuattie-Pimentel, F.J.
Gonzalez-Gonzalez, R. Saber, C.-I. Chen, H.R. Perlman, G.S.
Budinger, Chicago, IL, p.A6608
517 Influenza A Virus Infection Leads to Excess Monocyte
Recruitment and Severe Lung Injury in Juvenile Mice/
B.M. Coates, K.L. Staricha, K.M. Ridge, Chicago, IL, p.A6609
518 Opposing Heme Oxygenase-1 Expression Pattern in
Macrophages Cause Different Cell Behaviors/C. Canetti, C.
Freitas-Oliveira, A. Brogliato, M.M. Chaves, G. Sodre, C.F.
Benjamim, R. Coutinho-Silva, Rio de Janeiro, Brazil, p.A6610
WEDNESDAY MORNING
ATS 2016 • San Francisco