Final Program

MONDAY • MAY 16 219
2:30 FK506 Reduces Right Ventricular Cardiac Fibrosis in a BMP
Dependent Manner/X. Tian, J. Kuang, D. Sudheendra, S. Reddy,
M. Zhao, D. Bernstein, E.F. Spiekerkoetter, Stanford, CA, p.A4298
2:45 Influence of Sex on Estrogenic System in the Right
Ventricle/M. MacLean, E. Wallace, M. Nilsen, D. Morales-Cano,
Glasgow, United Kingdom, p.A4299
3:00 Effects of Pharmacological Aldosterone Antagonism by
Eplerenone on Pressure Overload-Induced Right Ventricular
Dysfunction/M. Boehm, C. Lu, T. Novoyatleva, N.D. Arnold, A.T.
Braithwaite, F. Grimminger, H.A. Ghofrani, N. Weissmann, W.
Seeger, A. Lawrie, R.T. Schermuly, B. Kojonazarov, Giessen,
Germany, p.A4300
3:15 Altered Insulin Signaling in Mutant BMPR2 Cardiomyocytes
Associated with Mitochondrial Dysfunction/M. Talati, J.P.
Fessel, S. Zhu, C. Jetter, N. Penner, J. West, A.R. Hemnes,
Nashville, TN, p.A4301
3:30 A Cardioprotective Estrogen Receptor a-Apelin Axis Mediates
Salutary Effects of 17b-Estradiol (E2) on Right Ventricular
Function in Pulmonary Hypertension/A. Frump, M. Albrecht, S.
Breulis Bonnet, F. Potus, S. Provencher, S. Bonnet, M.B. Brown, T.
Lahm, Indianapolis, IN, p.A4302
3:45 Right Ventricular End-Systolic Regional Wall Stress is
Associated with Invasive Measures of Right Ventricular
Afterload/C.J. Mullin, R. Tedford, C.P. Corona-Villalobos, S.L.
Zimmerman, I.R. Kamel, T. Kolb, R.L. Damico, D.A. Kass, P.M.
Hassoun, S.C. Mathai, Baltimore, MD, p.A4303
4:00 Pulmonary Arterial Hypertension Improvement by Macitentan
is Associated with an Increase in Right Ventricle, Peripheral
Muscle and Lungs Angiogenesis/V. Nadeau, S. Bonnet, R.
Paradis, F. Potus, E. Tremblay, C. Lambert, M. Iglarz, S.
Provencher, Quebec City, Canada, p.A4304
B97
MINI SYMPOSIUM
MITOCHONDRIA DYSFUNCTION IN THE
DEVELOPMENT OF LUNG DISEASE
2:15 p.m. - 4:15 p.m. MOSCONE CENTER
Chairing: N. Chandel, PhD, Chicago, IL
R. Guzy, MD, PhD, Chicago, IL
Oral Presentations
Room 2016/2018 (West Building, Level 2)
2:15 Staphylococcus Aureus Causes Mitochondrial Injury in Lung
Alveoli/J. Hook, J. Bhattacharya, New York, NY, p.A4305
2:30 Role of Mitochondrial (Dys-)Function for Cell Death and
Immune Activation in Influenza and Pneumococcal Infection/E.
Pappe, M. Mieth, J. Ruckert, J. Neudecker, T. Bauer, M. Tonnies,
N. Suttorp, T. Wolff, S. Hippenstiel, A. Hocke, A. Nerlich, Berlin,
Germany, p.A4306
2:45 Mice Lacking the Genes for Cytochrome P450 (CYP)1A
Enzymes Display Increased Susceptibility to Hyperoxic Lung
Injury, Oxidative DNA damage, and Oxidative Stress:
Implications for ALI/ARDS in Humans/B. Moorthy, W. Jiang, L.
Wang, X. Couroucli, K. Lingappan, Houston, TX, p.A4307
3:00 Metabolomic Profiling of Acutely Injured Human Alveolar
Epithelial Type 2 Cells Reveals Key Role of Tryptophan
Metabolism/A.J. Rogers, X. Fang, M. Wu, M. Zheng, G. Peltz,
M.A. Matthay, Stanford, CA, p.A4308
3:15 Mitochondrial DNA Released Following Necroptosis
Accumulates on RBCs/J. Mei, D. Qing, M. Hotz, D.L. Siegel, N.
Sondheimer, N.S. Mangalmurti, Philadelphia, PA, p.A4309
3:30 SIRT3, The Anti-Aging Major Mitochondrial Deacetylase, Is
Important for Preventing Pulmonary Fibrosis/R.P. Jablonski,
S.-J. Kim, P. Cheresh, D. Williams, L. Morales-Nebreda, M. Chi, Y.
Cheng, A. Yeldandi, A. Pardo, M. Selman, K.M. Ridge, D. Guis,
G.S. Budinger, D. Kamp, Chicago, IL, p.A4310
3:45 SH2 Domain-Containing Phosphatase-(SHP)-2 Attenuates
Fibrotic Responses Through Regulation of Fibroblast
Mitochondrial Metabolism and Autophagy/A.E. Tzouvelekis, G.
Yu, H. Lee, J.-S. Yi, J. Herazo-Maya, T. Woolard, A. Munivar, A.
Srivastava, P. Mannam, K. Sakamoto, G. DeIuliis, F. Ahangari, A.
Bennett, N. Kaminski, New Haven, CT, p.A4311
4:00 Macrophage Mitophagy and Fibrosis Development Requires
the Mevalonate Pathway/M. Vaid, J.L.L. Casey, L. Gu, A.B.
Carter, Birmingham, AL, p.A4312
B98
MINI SYMPOSIUM
SIGNALING, REMODELING AND CONTRACTION IN
THE AIRWAY
2:15 p.m. - 4:15 p.m. MOSCONE CENTER
Chairing: C.J. Koziol-White, PhD, New Brunswick, NJ
J.K. Burgess, PhD, Groningen, Netherlands
Oral Presentations
Room 2020/2022 (West Building, Level 2)
2:15 Premature Infants Have an Intrinsic Airway Secretory
Signature Characterized by Enhanced Production of Airway
Remodeling Growth Factors/R. Megalaa, S. Huseni, K. Pancham,
G.F. Perez, C.E. Rodriguez-Martinez, S. Kilaikode, M.C. Rose, S.
Wolf, G.R. Nino, Washington, DC, p.A4313
2:30 Mast Cell Activation by Hyperosmolar Mannitol-Challenge in
Isolated Human Small Airways/J. Safholm, J. Bood, S.-E. Dahlen,
M. Adner, Stockholm, Sweden, p.A4314
2:45 Impaired Crosstalk Between Airway Epithelium and Human
Bronchial Smooth Muscle Cells in COPD/E. Ahmed, A. Fort, L.
Knabe, I. Vachier, A. Virsolvy, S. Richard, P. Chanez, A. Bourdin,
Montpellier, France, p.A4315
MONDAY AFTERNOON
ATS 2016 • San Francisco