Final Program
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198 MONDAY • MAY 16<br />
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P1523<br />
Proinflammatory Cytokines and Bronchoalveolar Lavage from<br />
Idiopathic Pulmonary Fibrosis Patients Are Promoting the<br />
Expression of Fibrogenic Factors Through the Stimulation of<br />
Subepithelial Pneumonic Myofibroblasts. A Possible Role for<br />
the Novel Fibrogenic Factor TL1A/c/E. Bouros, E. Filidou, K.<br />
Arvanitidis, D. Mikroulis, P. Steiropoulos, G. Bamias, D. Bouros, G.<br />
Kolios, Alexandroupolis, Greece, p.A4152<br />
Cadmium Induces Vimentin Phosphorylation Through Both<br />
AKT and Cdc2 Signaling in Lung Cells/F.J. Li, H. Li, R. Surolia,<br />
Z. Wang, T. Kulkarni, G. Liu, V.J. Thannickal, V.B. Antony,<br />
Birmingham, AL, p.A4153<br />
Idiopathic Pulmonary Fibrosis Fibroblasts Exhibit<br />
Matrix-Autonomous Upregulation in Non-Muscle Myosin II/<br />
B.D. Southern, L.M. Grove, R.G. Scheraga, S. Abraham, K.A.<br />
Niese, T.T. Egelhoff, M.A. Olman, Cleveland, OH, p.A4154<br />
Evidence of Mesenchymal to Epithelial Transition in Human<br />
Fibroblasts Obtained from Normal Lungs and from Idiopathic<br />
Interstitial Pneumonias/C. Becerril, M. Montano, C. Ramos, J.<br />
Cisneros, C. Mendoza-Milla, M. Checa, A. Pardo, M. Selman,<br />
Mexico City, Mexico, p.A4155<br />
Danaparoid Attenuates Bleomycin-Induced Pulmonary<br />
Fibrosis in Mice/X. Wang, Y. Tanino, T. Nikaido, M. Kikuchi, Y.<br />
Sato, N. Fukuhara, K. Misa, R. Togawa, Y. Suzuki, M. Uematsu, A.<br />
Fukuhara, S. Sato, J. Saito, H. Yokouchi, M. Munakata, Fukushima,<br />
Japan, p.A4156<br />
The Role of p22phox-Dependent NADPH Oxidases in<br />
Bleomycin-Induced Interstitial Lung Disease/B.M. Nagy, C.<br />
Nagaraj, H. Olschewski, A. Olschewski, Graz, Austria, p.A4157<br />
The Role of Bronchiolar Epithelial Cell Migration in Idiopathic<br />
Pulmonary Fibrosis (IPF)/J. Fukumoto, R. Soundararajan, R.F.<br />
Lockey, N. Kolliputi, Tampa, FL, p.A4158<br />
Alveolar Epithelial Cells Release Pro-Fibrotic Mediators in<br />
Response to Endoplasmic Reticulum Stress/K.E. Black, V.A.<br />
Pace, A.M. Tager, Boston, MA, p.A4159<br />
Whole Genome Sequencing Identifies Susceptibility Loci for<br />
DPB/Y. Jin, D. Weng, Shanghai, China, p.A4160<br />
Proteasome-Dependent Degradation of IL-33 in Primary Human<br />
Pulmonary Fibroblasts/A. Clerman, Z. Noor, I.G. Luzina, S.P.<br />
Atamas, Baltimore, MD, p.A4161<br />
P1528<br />
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P1533<br />
P1534<br />
P1535<br />
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P1537<br />
Electrophysiological and Pharmacological Characterization of<br />
Primary K+-, Cl— and Ca2+-Conductances in Human<br />
Pulmonary Fibroblasts/M. Rahman, S. Mukherjee, V. Sheng, L.<br />
Janssen, Hamilton, Canada, p.A4166<br />
Establishment of Non-Infectious Exacerbation Pulmonary<br />
Fibrosis Model in Rat/S. Chen, D. Weng, Shanghai, China,<br />
p.A4167<br />
Identification of Novel Mediators in Lung Fibrosis/J. Verneau,<br />
London, United Kingdom, p.A4168<br />
Melatonin Attenuates TGFß1-Induced Epithelial-Mesenchymal<br />
Transition in Lung Alveolar Epithelial Cells/Y. Na, J. Kang,<br />
Shenyang City, China, p.A4169<br />
Nintedanib Reduces Pulmonary Fibrosis in a Model of<br />
Rheumatoid Arthritis Associated Interstitial Lung Disease/E.F.<br />
Redente, M.A. Aguilar, L.P. Lalire, B.L. Edelman, L. Wollin, D.W.H.<br />
Riches, Denver, CO, p.A4170<br />
Involvement of PARK2-Mediated Mitophagy in Idiopathic<br />
Pulmonary Fibrosis Pathogenesis/K. Kobayashi, J. Araya, H.<br />
Hara, S. Minagawa, M. Yoshida, K. Tsubouchi, T. Kadota, N. Saito,<br />
N. Sato, Y. Kurita, S. Ito, J. Kojima, T. Numata, Y. Kaneko, H.<br />
Asano, M. Yamashita, M. Odaka, T. Morikawa, K. Nakayama, K.<br />
Kuwano, Tokyo, Japan, p.A4171<br />
Functional, Histological and Biochemical Endpoints for<br />
Assessing Antifibrotic Efficacy in a Rat Model of Pulmonary<br />
Fibrosis/H.G. Hoymann, D. Schaudien, T. Hansen, M. Niehof, A.<br />
Braun, Hannover, Germany, p.A4172<br />
Urokinase Plasminogen Activator (uPA) Is Increased in<br />
Interstitial Lung Disease (ILD): A Potential Fibrogenic Mediator<br />
and Biomarker in ILD/M. Schuliga, J. Jaffar, A. Berhan, S.<br />
Langenbach, T. Harris, G. Westall, A.G. Stewart, Parkville,<br />
Australia, p.A4173<br />
Necroptosis Is Involved in Bleomycin Induced Experimental<br />
Lung Injury/Fibrosis/S.W. Park, J.-M. Lee, M.W. Lee, H.J. Seo,<br />
J.-H. Lee, A.S. Jang, D.-J. Kim, S.T. Uh, Y.H. Kim, C.-S. Park,<br />
Bucheon, Korea, Republic of, p.A4174<br />
How Basic Science Methodology Has Changed in the Context<br />
of the Bleomycin Model of Pulmonary Fibrosis/P.S. Kolb, D.<br />
Miller, J. Lee, C. Shimbori, P.-S. Bellaye, K. Ask, M.R.J. Kolb,<br />
Hamilton, Canada, p.A4175<br />
P1524<br />
P1525<br />
Analysis of Lung Injury Models by Using Human MUC1<br />
Transgenic Mice/T. Kubota, M. Sakai, S. Akita, S. Kawase, H.<br />
Ohnishi, A. Yokoyama, Nankoku City, Japan, p.A4162<br />
Rapamycin Insensitive mTOR Signalling Promotes TGF-ß<br />
Induced Pro-Fibrotic Gene Expression in Human Lung<br />
Fibroblasts/H. Woodcock, J. Eley, S. Peace, C. Nanthakumar,<br />
T.M. Maher, P. Mercer, R. Chambers, London, United Kingdom,<br />
p.A4163<br />
P1538<br />
SFTPA1 Mutation in Familial Idiopathic Interstitial Pneumonia<br />
and Lung Cancer/N. Nathan, V. Giraud, C. Picard, H. Nunes, F.<br />
Dastot Le Moal, P. Duquesnoy, B. Copin, M. Reynaud-Gaubert, D.<br />
Valeyre, L.-J. Couderc, T. Chinet, R. Borie, B. Crestani, V. Nau, S.<br />
Tissier, L. Galeron, A. De Ligniville, N. Kuziner, M. Simansour, L.<br />
Mansour Hendili, M. Legendre, C. Kannengiesser, A. Coulomb, L.<br />
Gouya, S. Amselem, A. Clement, Paris, France, p.A7845<br />
P1526<br />
Lung Fibroblasts Derived from Patients with Idiopathic Pulmonary<br />
Fibrosis Are Resistant to Alternaria Alternata-Mediated Cell<br />
Death/J. Im, R.S. Nho, Minneapolis, MN, p.A4164<br />
P1527<br />
The Role of Histone Deacetylase 8 in Fibroblast-Myofibroblast<br />
Differentiation/S. Saito, Y. Zhuang, G. Morris, J. Lasky, New<br />
Orleans, LA, p.A4165<br />
ATS 2016 • San Francisco