Final Program
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SUNDAY • MAY 15 87<br />
P1399<br />
P1400<br />
P1401<br />
P1402<br />
Facilitator:<br />
P1403<br />
P1404<br />
P1405<br />
P1406<br />
P1407<br />
P1408<br />
P1409<br />
P1410<br />
Autocrine and Paracrine Nicotinamide<br />
Phosphoribosyltransferase (NAMPT) Activity Promote<br />
Proliferation of Human Pulmonary Artery Smooth Muscle<br />
Cells/J. Chen, S. Singla, J.R. Sysol, S. Comhair, S. Ye, S.C.<br />
Erzurum, R.F. Machado, Chicago, IL, p.A2213<br />
Contribution of Vascular Smooth Muscle ROCK1 to<br />
SUGEN5416/Hypoxia-Induced Pulmonary Hypertension in<br />
Mice/D. Toksoz, R. Warburton, S. Abualkhair, K.C. Penumatsa, I.R.<br />
Preston, U. Kayyali, N.S. Hill, B.L. Fanburg, Boston, MA, p.A2214<br />
Interplay Between IL-13 and Energy Metabolism in Pulmonary<br />
Hypertension/W.-K. Cho, M.O. Kim, C.-M. Lee, J.A. Elias, C.G.<br />
Lee, S.I.S. Rounds, Providence, RI, p.A2215<br />
Osteopontin, a Key Mediator Expressed by Senescent<br />
Pulmonary Vascular Cells and Involved in Pulmonary<br />
Hypertension/E. Marcos, M. Saker, L. Lipskaia, S. Abid, A.<br />
Parpaleix, A. Houssaini, P. Validire, H. Noureddine, L. Boyer, N.<br />
Vienney, C.J. Lesaux, B. Maitre, M. Delcroix, R. Quarck, S. Adnot,<br />
Creteil, France, p.A2216<br />
R.L. Damico, MD, PhD, Baltimore, MD<br />
Abnormal Platelet Phenotype and Function in Pulmonary<br />
Arterial Hypertension/D. Taboada, K. Downes, H. McKinney, J.A.<br />
Guerrero, M.W. Besser, W.N. Erber, K. Freson, N.W. Morrell, W.H.<br />
Ouwehand, J. Pepke-Zaba, Cambridge, United Kingdom, p.A2217<br />
Calpain-Mediated Increase in Sodium-Hydrogen Exchanger<br />
Activity Is Necessary for Pathologic Smooth Muscle<br />
Proliferation in Pulmonary Arterial Hypertension/J. Huetsch, C.<br />
Larrain, L. Shimoda, Baltimore, MD, p.A2218<br />
Genome-Wide Association Study with Interactome-Based<br />
Scoring Identifies Dok4 and Ppp2ca as Novel Candidate Genes<br />
in High-Fat Diet-Induced Pulmonary Hypertension/N. Kelly, J.<br />
Radder, J. Baust, C. Burton, B. Agostini, J. Wood, A. Gregory, A.<br />
Leme, S.D. Shapiro, Pittsburgh, PA, p.A2219<br />
A Novel, Inhaled Prostacyclin Receptor Agonist for the<br />
Treatment of Pulmonary Arterial Hypertension/D.J. Rowlands,<br />
K. Coote, O. Bonneau, K. Choy, N. Duggan, M. Thomas, C.<br />
LeBlanc, S. Charlton, M. Healy, S. Grant, R. Strieter, Cambridge,<br />
MA, p.A2220<br />
Pulmonary Plexiform Arteriopathy in a Murine Model of<br />
Pulmonary Arterial Hypertension: Incidence and Histology/C.<br />
Bardita, M. Patel, M. Pritchard, N. Jeganathan, D. Predescu, S.A.<br />
Predescu, Chicago, IL, p.A2221<br />
Krüppel-Like Factor 4 in Pulmonary Arterial Endothelial Cells<br />
Modulates Smooth Muscle Cell Phenotype/M.A. Shatat, J.<br />
Peachey, A. Hamik, Cleveland, OH, p.A2222<br />
IL-18 Induces p38 MAP Kinase Activation and Adhesion<br />
Capacities in BMPR-II Impaired Pulmonary Microvascular<br />
Endothelial Cells/L. Vengethasamy, R. Gijsbers, A. Michiels, B.<br />
Tielemans, A. Wagenaar, R. Farre Marti, C. Belge, M. Delcroix, R.<br />
Quarck, Leuven, Belgium, p.A2223<br />
A High Throughput Screening Platform Targeting PDLIM5 for<br />
Pulmonary Hypertension/G. Zhou, H. Cheng, T. Chen, M. Tor, D.<br />
Park, J. Huang, N. Khati, Q. Zhou, L. Rong, Chicago, IL, p.A2224<br />
P1411<br />
Facilitator:<br />
P1412<br />
P1413<br />
P1414<br />
P1415<br />
P1416<br />
P1417<br />
P1418<br />
P1419<br />
P1420<br />
Facilitator:<br />
P1421<br />
P1422<br />
Altered Sugar Nucleotide Levels Facilitate Changes in<br />
Glycosylation in IPAH/L. Tian, J.W. Barnes, J. Loftis, J.M. Hiznay,<br />
S.A.A. Comhair, M.E. Lauer, R. Dweik, Cleveland, OH, p.A2225<br />
M.R. Nicolls, MD, Palo Alto, CA<br />
Alpha Globin Expressed by Pulmonary Artery Endothelial Cells<br />
Inhibits NO/sGC/cGMP Signaling in Response to Hypoxia/R.A.<br />
Alvarez, M.P. Miller, S. Hahn, D.A. Goncharov, E.A. Goncharova,<br />
M.T. Gladwin, A. Straub, Pittsburgh, PA, p.A2226<br />
Mechanical Stretch Combines with Adventitial<br />
Fibroblast-Derived Signals to Promote Macrophage Activation<br />
Through Metabolic Reprogramming in Vascular Remodeling/K.<br />
EL Kasmi, C. Myers, A. Flockton, S. Riddle, B.A. McKeon, M. Frid,<br />
K. Brodsky, H. Eltzschig, K.R. Stenmark, Aurora, CO, p.A2227<br />
Administration of Exosomes from Cardiosphere-Derived Cells<br />
in an Animal Model of Pulmonary Arterial Hypertension/R.C.<br />
Middleton, M. Fournier, E. Marban, M.I. Lewis, Los Angeles, CA,<br />
p.A2228<br />
Identification of Candidate GPCRs in Pulmonary Arterial<br />
Hypertension: Role of Purinoceptor 2 (P2Y2) in Pulmonary<br />
Vascular Remodeling/G. Viswanathan, X. Tian, S. Tunaru, P.<br />
Singh, W. Seeger, S. Offermanns, R.T. Schermuly, Giessen,<br />
Germany, p.A2229<br />
Oral CAR Peptide Adjuvant Enhances Sildenafil Therapy for<br />
Pulmonary Arterial Hypertension/D. Mann, X. Yue, J. Sawada,<br />
M. Komatsu, Goleta, CA, p.A2230<br />
CAR Peptide Adjuvant Enables Effective Pulmonary<br />
Hypertension Treatment with Imatinib at Reduced Doses/D.<br />
Mann, X. Yue, J. Sawada, N. Ambalavanan, M. Komatsu, Goleta,<br />
CA, p.A2231<br />
Composition and Structure of the Vascular Basement<br />
Membrane in Pulmonary Hypertension/J. Hoffmann, B. Ghanim,<br />
W. Klepetko, G. Kovacs, H. Olschewski, A. Olschewski, G.<br />
Kwapiszewska, Graz, Austria, p.A2232<br />
Inhibition of L-Type Amino Acid Transporter 1 (LAT-1) Export<br />
of S-Nitrosothiols (SNO) Promotes Red Blood Cell Adhesion to<br />
Endothelial Cells/L.B.M. Dosier, H. Zhu, T.J. McMahon, Durham,<br />
NC, p.A2233<br />
Mas Receptor Activation Increases SOD2 Expression in<br />
Pulmonary Vessels and Decreases Endothelial<br />
Dysfunction/E.J. Carrier, A. Rathinasabapathy, S. Menon, M.R.<br />
Kaplowitz, C.D. Fike, J.D. West, Nashville, TN, p.A2234<br />
S. Bonnet, PhD, Quebec City, Canada<br />
Serotonin Augments Proliferation of Neonatal Calf Pulmonary<br />
Artery Fibroblasts/C.A. Delaney, A. Flockton, E. Nozik-Grayck,<br />
K.R. Stenmark, Aurora, CO, p.A2235<br />
Comparative Analysis of Global Gene Expression Profile in<br />
Mouse Strains After Hypoxic Challenge Either Susceptible to<br />
or Resistant to Chronic Hypoxia-Induced Pulmonary<br />
Hypertension/W. Nichols, N. Dasgupta, P. Hale, T. Le Cras, P.<br />
Pastura, M. Pauciulo, Cincinnati, OH, p.A2236<br />
SUNDAY MORNING<br />
ATS 2016 • San Francisco