Final Program

192 MONDAY • MAY 16
P1408
Enhanced Spontaneous TGFb1 Production and Defective LPS
Responses in Monocytes from Patients with Scleroderma
Related Interstitial Lung Disease/H. Pan, H. Ding, M. Gulati,
W.H. Fares, Y. Gan, D. Carrano, P. Adonteng-Boateng, X. Peng, E.
Herzog, New Haven, CT, p.A4026
P1409 Increased Expression of Plasminogen Activator Inhibitor 1
Contributes to Alveolar Type II Cell Senescence in IPF Lung/C.
Jiang, G. Liu, Q. Ding, V.B. Antony, V.J. Thannickal, R.-M. Liu,
Birmingham, AL, p.A4027
P1410
P1411
P1412
P1413
Effect of Blockade of Fibroblast Growth Factor Receptor
Signaling in Experimental Pulmonary Fibrosis in Mice/S. Sato,
H. Goto, S. Morizumi, H. Okazaki, Y. Chen, H. Kawano, Y. Toyoda,
M. Hanibuchi, M. Azuma, Y. Nishioka, Tokushima, Japan, p.A4028
Hypoxia Induces Endoplasmic Reticulum Stress in Alveolar
Epithelial Cells: Potential Implication in Idiopathic Pulmonary
Fibrosis/E. Boncoeur, A. Naguez, R. Label, A. Soumare, O.
Bernard, D. Marchant, Y. Uzunhan, T.F. Gille, C. Planes, Bobigny,
France, p.A4029
Connective Tissue Growth Factor Is Associated with
Pulmonary Hypertension Complicating Idiopathic Pulmonary
Fibrosis/A. Biswas, C. Fu, G. Brown, B. Amador, M. Wallet, S.
Wallet, E. Scott, A.J. Bryant, Gainesville, FL, p.A4030
Potential Role of Altered Clusterin Expression and
Localization in IPF to Limit Fibroproliferation/L. Peix, I.C.
Evans, D.R. Pearce, J.K. Simpson, T.M. Maher, R.J. McAnulty,
London, United Kingdom, p.A4031
P1414 Tranilast Inhibits Pulmonary Fibrosis in Mice/M. Kato, F.
Takahashi, H. Ihara, H. Baskoro, Y. Koinuma, K. Suina, T. Asao, Y.
Fujimoto, R. Kanemaru, K. Muraki, T. Sato, N. Shimada, M.
Takahashi, K. Takahashi, Tokyo, Japan, p.A4032
P1415
P1416
P1417
P1418
P1419
P1420
Adenylate Cyclase Pathway and Progression of Fibrosis/S.
Mukherjee, L. Janssen, Hamilton, Canada, p.A4033
A Synthetic Cannabinoid that Exerts a Potent Anti-Fibrotic
Effect During the Fibrogenic Phase of Bleomycin Lung/
M. Lucattelli, S. Fineschi, E. Selvi, E. Garcia Gonzalez, B.
Bartalesi, G. De Cunto, S. Lorenzini, M. Galeazzi, G. Lungarella,
Siena, Italy, p.A4034
Epitopes of Anti-Fibrotic mAbs Against Integrin adb1 Reveal
Complete Aminoacid Conservation Within Mammalian
Species/Y. Yokosaki, N. Kawashima, N. Nishimichi, Hiroshima,
Japan, p.A4035
Identification of a New Specific Auto-Antibody of Idiopathic
Pulmonary Fibrosis/M. Hikichi, Y. Gon, S. Maruoka, T. Morisawa,
K. Mizumura, T. Ooki, R. Ito, H. Hiranuma, F. Kumasawa, Y. Kozu,
E. Tsuboi, S. Hashimoto, Tokyo, Japan, p.A4036
Study on the Mechanism of Action of Polymyxin B Hemoperfusion
Therapy in Acute Exacerbation of Interstitial Pneumonias/T.
Utsunomiya, M. Yuka, T. Yamamoto, K. Aoe, K. Oishi, T. Matsumoto,
H. Ueoka, M. Yano, Y. Mimura, Ube, Japan, p.A4037
Light Chain Genotype Analysis of GM-CSF Autoantibody in
Autoimmune Pulmonary Alveolar Proteinosis by Next
Generation Sequencing/A. Hashimoto, T. Tanaka, A. Hayakawa,
Y. Itoh, T. Nei, K. Shiiya, M. Higuchi, K. Nakagaki, T. Takada, K.
Akasaka, R. Tazawa, K. Nakata, Niigata, Japan, p.A4038
P1421
P1422
P1423
P1424
P1425
P1426
P1427
P1428
P1429
P1430
P1431
P1432
P1433
Activation of Adenylyl Cyclase/cAMP Pathway Inhibits
Glycolysis and Collagen Production in Human Lung
Fibroblasts/L.J. Witt, R. Nigdelioglu, D.D.-W. Wu, A.Y. Meliton,
N.O. Dulin, R.B. Hamanaka, G.M. Mutlu, Chicago, IL, p.A4039
Revisiting Pulmonary Ossification/S.G. Ramos, L.B. Rocha,
M.R. Celes, A.C. Freitas, C. Tefe-Silva, K.M. Mata, L.G.B.V.
Santoro, M.A. Abreu, E.M. Floriano, J. Baddini-Martinez, Ribeirao
Preto, Sao Paulo, Brazil, p.A4040
OPG May Protect Bleomycin-Induced Pulmonary Fibrosis by
Inhibiting SMAD2/3 Dependent TGF-b1 Activation/D. Weng, H.
Li, Shanghai, China, p.A4041
The Palliative Effect of Amniotic Membrane Derived Cells
(AMDC) and Conditioned Media on Lung Fibrosis/A.C.
Zamora-Martinez, D.M. Hebrink, P.E. Jenson, T.J. Kottom, A.H.
Limper, Rochester, MN, p.A4042
Phosphatidylethanolamine Induces Apoptosis in Primary
Cultures of Normal Human Lung Fibroblasts/B. Tlatelpa
Romero, C. Mendoza Milla, J.M. Justo Janeiro, L.G. Vazquez De
Lara, Puebla, Mexico, p.A4043
Metformin Attenuates Pulmonary Fibrosis on the Established
Mouse Model Induced by Bleomycin/S.H. Jeong, Y.J. Kim, J.W.
Park, E.S. Son, S.Y. Kyung, S.M. Kang, Incheon, Korea, Republic
of, p.A4044
Pirfenidone Inhibits p38 Mediated Generation of Procoagulant
Microparticels by Human Alveolar Epithelial Cells/T. Neri, S.
Lombardi, F. Faita, S. Petrini, C. Balia, V. Scalise, R. Pedrinelli, P.
Paggiaro, A. Celi, Pisa, Italy, p.A4045
Influenza-Induced Collagen Deposition and Peribronchial
Fibrosis Occurs Independent of Gq/11-Mediated TGFb
Generation in the Alveolar Epithelium/A.E. John, A. Habgood,
A.L. Tatler, J. Porte, S. Offermanns, R.G. Jenkins, Nottingham,
United Kingdom, p.A7834
Characterizing the Maturation of TGF-b Induced Pulmonary
Fibrotic Scar: Quantitation of Extracellular Matrix Protein
Synthesis, Remodeling and Crosslinking Rates/M. Decaris, C.
Shimbori, S. Liu, M. Gatmaitan, E. Nyangau, K. Ask, K. Li, M.
Hellerstein, P.-S. Bellaye, J. Gauldie, S. Turner, M. Kolb,
Emeryville, CA, p.A7835
RNA Sequencing of Alveolar Epithelial Cells Derived from
Human Lung Explants/Y. Sakairi, J.A. Villalba, J.C. Osorio, S.G.
Chu, K. Tsoyi, H.J. Goldberg, S. El-Chemaly, P. Camp, G. Washko,
M.A. Perrella, I.O. Rosas, Boston, MA, p.A7836
Stearoyl CoA Desaturase-1 Activity Is Required for Resolving
Endoplasmic Reticulum Stress and Suppressing Fibrotic
Responses in the Lung/F. Romero, D. Shah, G. George, R.
Summer, Philadelphia, PA, p.A7837
Detection of CFTR Function and Modulation in Primary Human
Nasal Cell Spheres/J.J. Brewington, E. Filbrandt, C.-S. Moon, A.
Ostmann, A. Naren, J.P. Clancy, Cincinnati, OH, p.A7838
The Role of Endocannabinoid System in Regulation of
Radiation-Induced Pulmonary Fibrogenesis/E. Berdyshev, I.
Bronova, K. Erdelyi, A. Makriyannis, P. Pacher, Denver, CO, p.A7839
ATS 2016 • San Francisco