Final Program

330 TUESDAY • MAY 17
509 A Mechanistic Role for Autoantibodies in Emphysema
Development/S.E. Stephenson, A. Alawieh, S. Tomlinson, C.
Atkinson, Charleston, SC, p.A6330
510 Sputum Secretory Immunoglobulin A1 (SIgA1) from Patients
with COPD Enhances Opsonophagocytosis of Nontypeable
Haemophilus influenzae and Moraxella catarrhalis/P. Tunsupon,
M. Smith, C. Wrona, S. Sethi, Buffalo, NY, p.A6331
511 Importance of Tregs and IL-10 in COPD Progression Induced
by Cigarette Smoke Exposure/J.T. Ito, D.A.B. Cervilha, D.S.
Sales, J.D. Lourenco, J.J. Simao, C.R. Olivo, M.A. Martins,
F.D.T.Q.S. Lopes, Sao Paulo, Brazil, p.A6332
512 Effects of Statins on Innate Immune Cells in Lung Tissues of
Mild to Moderate COPD/S.F. Van Eeden, S. Miller, K. Hiraiwa, E.
Lin, D. Ng, J.C. Hogg, Vancouver, Canada, p.A6333
513 Human Beta Defensin 2 Levels Are Reduced in the Sputum of
Chronic Obstructive Pulmonary Disease (COPD) Patients and
Are Associated with the Occurrence of Exacerbations/C.
McCrae, Y. Zhou, J. Qian, J. Zheng, R. Tang, A. Nilsson, M. Zhang,
P. Bruijnzeel, J. Saltzman, O. Vaarala, R. Chen, N. Zhong, Molndal,
Sweden, p.A6334
514 Bacterial Regulation of Pathogen Recognition Receptors in
Macrophages in COPD Are Differentially Modified by
Budesonide and Fluticasone Propionate Ex Vivo/K.A. Provost,
M. Smith, A. Miller-Larsson, G.D. Gudleski, S. Sethi, Buffalo, NY,
p.A6335
515 Rhinovirus Impairs Phagocytosis of Bacteria by Monocyte
Derived Macrophages in Chronic Obstructive Pulmonary
Disease/L.J. Finney, K.B.R. Belchamber, M.R. Edwards, P. Mallia,
S.L. Johnston, L. Donnelly, J.A. Wedzicha, London, United
Kingdom, p.A6336
516 Change in Titer of Serum Antibodies Directed at the Bacterial
Surface Reflect the Frequency of Lower Airway Bacterial
Carriage and Infection in COPD/B. Mustafa, C. Wrona, T.
Murphy, S. Sethi, Buffalo, NY, p.A6337
517 IRF-3 Involved in Pathogenesis of Pulmonary Emphysema/T.
Ishii, K. Hosoki, Y. Nikura, T. Nagase, N. Yamashita, Tokyo, Japan,
p.A6338
518 Streptococcus Pneumoniae Colonization in Lower Airways
Accelerates the Progression of Cigarette Smoke-Induced
Chronic Obstructive Pulmonary Disease/X. Gou, Q. Zhang, S.
More, G. Bamunuarachchi, Y. Liang, F. Khan, C. Wang, L. Liu,
Stillwater, OK, p.A6339
519 Inefficiency of Influenza Vaccination in COPD Patients Is
Associated with Defect of B Cell Differentiation and Decrease
of IFNg CD4+ T Cells Production/A. Parpaleix, L. Boyer, A.
Wiedemann, C. Lacabaratz, A. Lino, A. Covali-Noroc, C. Chouaid,
B. Maitre, Y. Levy, L. Jean-Daniel, S. Adnot, Creteil, France,
p.A6340
520 Secretory IgA Deficiency in Individual Small Airways in COPD
Correlates with Local Activation of Adaptive Immunity/V.V.
Polosukhin, B.W. Richmond, R.-H. Du, J.M. Cates, L.B. Ware, J.W.
Lee, A.V. Kononov, T.S. Blackwell, Nashville, TN, p.A6341
521 Smoke Exposure Drives Lung Disease Progression by
Reducing Protein Tyrosine Phosphatase 1B Activity Via
Toll-Like Receptor-9 Signaling/P. Geraghty, N. Baumlin, M.
Salathe, R. Foronjy, New York, NY, p.A6342
522 Macrophages from Patients with Z Mutation in Antitrypsin
Have Increased Proteolytic Activity on Extracellular Matrix
Through Matriptase-MMP-14/K. Krotova, G.W. Marek, L. Wang,
N. Khodayari, F. Rouhani, M.L. Brantly, Gainesville, FL, p.A6343
523 Severe Reduction of Peripheral T Cells Does Not Afford
Protection Toward Emphysema and Bronchial Remodelling
Induced in Mice By Cigarette Smoke/G. Lungarella, G. De Cunto,
B. Lunghi, B. Bartalesi, E. Cavarra, S. Fineschi, C. Ulivieri, M.
Lucattelli, Siena, Italy, p.A6344
524 Active Smoking is Associated with Increased Eosinophils in
Bronchoalveolar Lavage but Not in Sputum or Peripheral Blood:
SPIROMICS Immunophenotyping Sub-Study/S.X. Li, A.J. Hirzel,
C.M. Freeman, S.W. Crudgington, V.R. Stolberg, J. Sonstein, N.E.
Alexis, P.V. Basta, E.E. Carretta, S.A. Christenson, D.J. Couper,
C.M. Doerschuk, M.K. Han, N.N. Hansel, A.T. Hastie, R.J. Kaner,
F.J. Martinez, W.K. O'Neal, R. Paine, III, S.I. Rennard, D. Shimbo,
P.G. Woodruff, M. Zeidler, J.L. Curtis, Ann Arbor, MI, p.A6345
525 M2 Macrophages Promote the Chronic Progression of
Experimental Emphysema/J.M. Craig, N. Limjunyawong, H.A.D.
Lagasse, A. Poupore, A. Scott, W. Mitzner, Baltimore, MD, p.A6346
C108
POSTER DISCUSSION SESSION
ADVANCES IN LUNG FUNCTION ASSESSMENT
2:15 p.m. - 4:15 p.m. MOSCONE CENTER
Room 2024 (West Building, Level 2)
Poster Viewing 2:15-3:00
Discussion 3:00-4:15
Chairing: C.G. Irvin, PhD, Burlington, VT
B. Oppenheimer, MD, New York, NY
601 High-Flow Nasal Cannula Offers Greater Reduction of Effort of
Breathing in Children of Lower Weight/T.W. Weiler, A.
Kamerkar, J. Hotz, P.A. Ross, C.J. Newth, R.G. Khemani, Los
Angeles, CA, p.A6347
602 Does Passive Expiratory Volume Detect Bronchodilator
Responsiveness in Infants with Bronchopulmonary
Dysplasia?/B.J. Clouse, S. Sitaram, L. Wei, S.R. Jadcherla,
Columbus, OH, p.A6348
603 Diffusion-perfusion Relationship Measured by a Rebreathing
Technique in Mice with Bleomycin Induced Lung Injury/D.M.
Dane, H. Lu, E. Wechsler, P. Ravikumar, C.C.W. Hsia, Dallas, TX,
p.A6349
604 Residual Volume and Expiratory Flow Distinguishes Interstitial
Lung Disease from Other Causes of Lung Restriction/B. Singh,
K. Raj, S.S. Dhaliwal, W. Noffsinger, Nedlands, Australia, p.A6350
ATS 2016 • San Francisco