294 TUESDAY • MAY 17 P659 P660 P661 P662 P663 P664 P665 Facilitator: P666 P667 P668 P669 P670 P671 Can Information from Cardiopulmonary Exercise Testing Predict Outcome After Pulmonary Rehabilitation in Patients with COPD?/R.J. Perez, R. ZuWallack, D. Datta, Farmington, CT, p.A5731 Comorbidities in Patients with Chronic Obstructive Pulmonary Disease and Pulmonary Rehabilitation Outcomes/P. Tunsupon, A. Lal, M.A. Khamis, M.J. Mador, Buffalo, NY, p.A5732 Short Duration Dyspnea Challenge Test to Assess Severity of Dyspnea in Patients with Chronic Obstructive Pulmonary Disease/P. Sharma, N.R. Morris, M. Sabaratnam, L. Adams, Southport, Australia, p.A5733 Chronic Obstructive Pulmonary Disease (COPD) Patients After Pulmonary Rehab: Psycho-Social Factors/M. Dekker, P. Saini, R. Priori, C. Barretto, M. Sillen, M. Spruit, Eindhoven, Netherlands, p.A5734 Clinical, Socio-Demographic and Psychological Characteristics of Participants and Non-Participants to Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease (COPD)/E.D. Rivard, V. Pepin, F. Beaucage, L. Blais, G. Moullec, RESP Team, Montreal, Canada, p.A5735 Trends of Symptom Scores in COPD Patients Followed in a Tertiary Care Pulmonology Clinic: Are Patients Feeling Better?/R. Evans, N. Menon, C.S. Tsai, S.A. Evans, D.W. Drumm, A.L. Berger, P.F. Simonelli, Danville, PA, p.A5736 Pulmonary Rehabilitation Is Associated with Improvement in Short Physical Performance Battery Scores in COPD/C. Teneback, P. Savage, Burlington, VT, p.A5737 H. Demeyer, PhD, Leuven, Belgium Postural Deviations in People with Chronic Obstructive Pulmonary Disease (COPD)/A.L. Lee, K. Zabjek, R.S. Goldstein, D. Brooks, Toronto, Canada, p.A5738 “Who Wants to Hurt?” - A Qualitative Exploration of Pain Experiences and Their Meaning in People with Chronic Obstructive Pulmonary Disease (COPD)/A.L. Lee, S.L. Harrison, R.S. Goldstein, D. Brooks, Toronto, Canada, p.A5739 Chronic Pain in Chronic Obstructive Pulmonary Disease (COPD): Prevalence, Clinical Implications and Psychological Responses/A.L. Lee, R.S. Goldstein, D. Brooks, Toronto, Canada, p.A5740 Light Intensity Physical Activity (LIPA) Is Associated with Patient Reported Outcomes in People with COPD/N.S. Cox, A.T. Burge, A. Mahal, C.J. Hill, A.L. Lee, R. Moore, C. Nicolson, A. Lahham, R. Ndongo, C.F. McDonald, A.E. Holland, Melbourne, Australia, p.A5741 The Minimal Clinically Important Difference for Daily Step Counts in Persons with COPD/M. Teylan, D. Homsy, O. Okunbur, J. Gao, E. Garshick, M.L. Moy, Boston, MA, p.A5742 Objectively Measured Sedentary Behavior in People with COPD and Assisted Living Residents/J.L. Larson, C. Vos, S. Woo, D. Fernandez, D. Buckery, Ann Arbor, MI, p.A5743 P672 P673 C67 Objectively Measured Physical Activity and Sleep Quality in Chronic Obstructive Pulmonary Disease/Z. Parwanta, A.T. Burge, V. Pepin, N.S. Cox, A.E. Holland, Montreal, Canada, p.A5744 A Screening Tool to Predict Obstructive Sleep Apnea in Patients with Chronic Obstructive Pulmonary Disease: A Pilot Study of the UCSD COPD-OSA Questionnaire/X. Soler, S.-Y. Liao, A.L. Ries, A. Malhotra, San Diego, CA, p.A5745 THEMATIC POSTER SESSION ACUTE LUNG INJURY 9:00 a.m. - 4:15 p.m. MOSCONE CENTER Viewing: Posters will be on display for entire session. Area M, Hall D (North Building, Lower Level) Discussion: 11:00-11:45: authors will be present for individual discussion 11:45-12:45: authors will be present for discussion with assigned facilitators Facilitator: P1475 P1476 P1477 P1478 P1479 Facilitator: P1480 P1481 L.G. Dobbs, MD, Oakland, CA Altered Expression of IRF1 and Its Regulatory Genes in Lipopolysaccharide-Induced Acute Lung Injury Mouse Model/J.-R. Park, H. Lee, S.-R. Yang, Chuncheon, Korea, Republic of, p.A5746 F Box Protein FBXO10 Targets the Receptor for Advanced Glycation End Products (RAGE) for Ubiquitination and Degradation in Human Bronchial Epithelial Cells/J. Evankovich, S. Dunn, A. Mckelvey, T. Lear, B.B. Chen, R. Mallampalli, Pittsburgh, PA, p.A5747 Attenuation of Lung Injury by Lung Epithelium Cell Specific Knockdown of Nampt Gene Expression/G. Bi, N.N. Nsumu, L. Zhang, D. Heruth, S. Ye, Kansas City, MO, p.A5748 Epithelial Cells Internalize Macrophage-Derived Microparticles: Mechanisms of Uptake and Modulation by the Extracellular Environment/D.J. Schneider, J.M. Speth, L.R.K. Penke, M. Peters-Golden, Ann Arbor, MI, p.A5749 Deletion of aENaC in Alveolar Type I Cells Demonstrates the Integral Role of Type I Cells in Maintaining Lung Fluid Balance/M. Johnson, S. Balan, A.M. Gillespie, L. Dobbs, San Francisco, CA, p.A5750 G.M. Mutlu, MD, Chicago, IL AKB-9785, a VE-PTP Inhibitor, Decreases Inflammation and Alters the Angiopoietin/Tie2 System Dynamic Response in a S. Aureus Sepsis Model/R.R. Bartz, T. McCord, H. Suliman, T. Orr, C.A. Piantadosi, C. Kontos, Durham, NC, p.A5751 Differential Pulmonary Gene and Protein Expression in Wild Type, Cyp1a1-Null and Cyp1a2-Null Mice in Acute Hyperoxic Lung Injury: Role of Cytochrome P450 (CYP)1A/K. Lingappan, S. Maity, W. Jiang, L. Wang, X. Couroucli, C. Coarfa, B. Moorthy, Houston, TX, p.A5752 ATS 2016 • San Francisco
TUESDAY • MAY 17 295 P1482 P1483 P1484 Facilitator: P1485 P1486 P1487 P1488 P1489 Facilitator: P1490 P1491 P1492 P1493 Peptide-Based Activation of GPR116 on Alveolar Epithelial Cells Induces G Protein-Coupled Responses and Modulates Alveolar Surfactant Pool Sizes In Vivo/J. Bridges, A. Filuta, K. Brown, K. Arora, A. Naren, M.-G. Ludwig, K. Seuwen, J. Jaros, W. Miller, Cincinnati, OH, p.A5753 KLF2 Enhances Barrier Protection by Directly Regulating RapGEF3, a GEF Which Activates Rac1/D.D.-W. Wu, R.-T. Huang, M. Jain, A.A. Birukova, J. Lloyd, K.G. Birukov, G.M. Mutlu, Y. Fang, Chicago, IL, p.A5754 G-CSF Promotes Alveolar Epithelial Repair Following Acute Lung Injury/A.J. Paris, Y. Liu, N. Dai, J. Mei, K. Hudock, G.S. Worthen, Philadelphia, PA, p.A5755 E. Roan, PhD, Memphis, TN A Novel Cytoplasmic Domain in ENaC-Alpha Mediates Activation by the Lectin-Like Domain of TNF/I. Czikora, Q. Yue, A. Alli, B.J. Duke, T.L. Thai, R. Lemmens-Gruber, B. Fischer, T. Chakraborty, W. Shabbir, D.C. Eaton, R. Lucas, Augusta, GA, p.A5756 LPS Relocates Nuclear Resided Fbxo24 into Cytoplasmic Compartment to Augment Histone Acetyltransferase GCN5L2 Medicated Transcriptional Activity in Lung Epithelial Cells/J. Li, Q. Wu, C. Zou, Pittsburgh, PA, p.A5757 Examining the Collapse-Mechanism of the Pulmonary Surfactant/M.R. Al-Saiedy, S.L. Nelson, A. Tarokh, F.H.Y. Green, M.W. Amrein, Calgary, Canada, p.A5758 The EMT Process Occurs in Early Pulmonary Fibroproliferation of LPS-Induced ARDS in Rats/P. Wang, M. Yu, M. Wang, B. Zhong, J. Li, X. Zhong, P. Zhao, Q. Zhang, J. Yuan, G. Jiao, Chengdu City, China, p.A5759 Myosin Phosphatase Protects Against LPS-Induced Pulmonary Endothelial Barrier Dysfunction/A. Kasa, B.A. Ghorshkov, K.-M. Kim, S. Kumar, S.M. Black, D. Fulton, C. Dimitopolou, J.D. Catravas, A.D. Verin, Augusta, GA, p.A5760 I. Vadasz, MD, Giessen, Germany TGF-b Promotes Ubiquitination, Endocytosis and Degradation of the Protein Transporter Megalin in Alveolar Epithelial Cells/L.C. Mazzocchi, C. Vohwinkel, W. Seeger, I. Vadasz, Giessen, Germany, p.A5761 Destabilization of Lysophosphatidic Acid Receptor 1 Reduces Cytokine Release and Protects Against Lung Injury/J. Zhao, J. Wei, D. Su, R.K. Bowser, L. Zhang, A.M. Jacko, Y. Zhao, Pittsburgh, PA, p.A5762 The O-Glycosylated Ectodomain of FXYD5 Impairs Alveolar Epithelial Integrity by Inhibiting the Intercellular Trans-Dimerization of the Na,K-ATPase/L.A. Dada, E. Tokhtaeva, P.N. Soni, K.M. Ridge, G. Sachs, J.I. Sznajder, O. Vagin, Chicago, IL, p.A5763 Tumor Necrosis Factor Alpha (TNF- a) Increases Strain Field Heterogeneity in Alveolar Epithelial Cells Leading to Monolayer Damage/J.D. Herwig, C.M. Waters, E. Roan, Memphis, TN, p.A5764 P1494 Facilitator: P1495 P1496 P1497 P1498 P1499 Facilitator: P1500 P1501 P1502 P1503 P1504 Facilitator: P1505 Hypercapnia Impairs Cell Junction Formation by Promoting Ubiquitination and Proteasomal Degradation of the Na,K-ATPase b-Subunit in Alveolar Epithelial Cells/V. Kryvenko, N.M. Gabrielli, L.A. Dada, W. Seeger, J.I. Sznajder, I. Vadasz, Giessen, Germany, p.A5765 D.W. Kamp, MD, Chicago, IL The Effect of PGC-1a on Acute Lung Injury/J. Wang, Y. Jiao, Chongqing City, China, p.A5766 AMP-Activated Protein Kinase and Extracellular Signal-Regulated Kinase 1/2 Mediate Hypercapnia-Induced Polyubiquitination and Endocytosis of ENaC in the Alveolar Epithelium/P. Gwozdzinska, B.A. Buchbinder, W. Seeger, I. Vadasz, Giessen, Germany, p.A5767 Exploring the Distinct Role of the Secreted Form of Nampt for the Regulation of Pro-Survival Mechanisms in Endothelial Cells in the Context of Acute Lung Injury/R.C. Oita, W. Ma, S. Chiang, T. Wang, S.M. Black, J. Yuan, J.G.N. Garcia, Tucson, AZ, p.A5768 GSK3b Stability Is Regulated by Its Activation State and Influences Inflammation in Lung Epithelial Cells/T. Suber, J. Cai, J. Zhao, Y. Zhao, R. Mallampalli, Pittsburgh, PA, p.A5769 The Mitochondrial Calcium Uniporter Is a Therapeutic Target in Acute Lung Injury/M.N. Islam, G.A. Gusarova, S. Das, J. Bhattacharya, New York, NY, p.A5770 I. Rahman, PhD, Rochester, NY Mitochondrial OXPHOS (Complex III) Is an Important Regulator of Fibroblast Differentiation: Implications in Bioenergetics and Cellular Senescence/W. Lei, C.A. Lerner, I. Sundar, H. Yao, I. Rahman, Rochester, NY, NY, p.A5771 An Antidotal Therapy for Carbon Monoxide Poisoning Improves Survival by Reversing Hemodynamic Collapse and Mitochondrial Dysfunction/J.J. Rose, L. Wang, Q. Xu, D. Osei-Hwedieh, E.N. Schwoegl, Q. Nguyen, C. Corey, X.Y.N. Huang, C.F. McTiernan, J. Tejero, C.P. O’Donnell, S. Shiva, M.T. Gladwin, Pittsburgh, PA, p.A5772 PBMCs from Patients with Limited Systemic Sclerosis Demonstrate Altered Mitochondrial Dynamics/S. Lenna, G.A. Farina, H.W. Farber, R. Lafyatis, M. Trojanowska, Boston, MA, p.A5773 Specificity of Metabolic Stress in the Regulation of Mitochondria Dysfunction Induced mtDNA Release in Lung Epithelial Cells/J.-S. Moon, M.J. Koo, S.W. Ryter, K. Nakahira, A.M.K. Choi, New York, NY, p.A5774 Small Molecule Inhibition of the E3 Ligase Subunit Fbxo7 Prevents Mitochondrial Damage/Y. Liu, T. Lear, B.B. Chen, R. Mallampalli, Pittsburgh, PA, p.A5775 H. Kubo, MD, PhD, Tokyo, Japan Autophagy Deficient Mesenchymal Stromal Cells Are More Susceptible to Oxidative Injury as a Result of Mitochondrial Dysfunction/S. Ghanta, K. Tsoyi, C.A. Piantadosi, A.M.K. Choi, M.A. Perrella, Boston, MA, p.A5776 TUESDAY MORNING ATS 2016 • San Francisco
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American Thoracic Society Internati
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TABLE OF CONTENTS ATS 2016 INTERNAT
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2 FRIDAY • MAY 13 PG2A CLINICAL P
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4 FRIDAY • MAY 13 Target Audience
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6 FRIDAY • MAY 13 11:15 Case Disc
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8 FRIDAY • MAY 13 Chairing: H.B.
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10 FRIDAY • MAY 13 10:25 Advanced
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12 FRIDAY • MAY 13 Objectives At
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14 SATURDAY • MAY 14 Abdominal Ul
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16 SATURDAY • MAY 14 PG17 BASIC
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18 SATURDAY • MAY 14 1:05 In What
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20 SATURDAY • MAY 14 10:30 Practi
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22 SATURDAY • MAY 14 Objectives A
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24 SATURDAY • MAY 14 10:10 Is My
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26 SUNDAY • MAY 15 Chairing: D.M.
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28 SUNDAY • MAY 15 Chronic Cough:
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30 SUNDAY • MAY 15 • understand
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32 SUNDAY • MAY 15 Target Audienc
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34 SUNDAY • MAY 15 Oral Presentat
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36 SUNDAY • MAY 15 9:15 Hyperpola
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38 SUNDAY • MAY 15 310 A Smartpho
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40 SUNDAY • MAY 15 103 Immunosupp
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42 SUNDAY • MAY 15 A26 POSTER DIS
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44 SUNDAY • MAY 15 822 Incidence
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46 SUNDAY • MAY 15 519 Maternal H
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48 SUNDAY • MAY 15 P14 P15 P16 P1
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50 SUNDAY • MAY 15 P1545 P1546 Fa
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52 SUNDAY • MAY 15 P60 P61 Facili
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54 SUNDAY • MAY 15 P149 P150 Faci
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56 SUNDAY • MAY 15 P749 P750 P751
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58 SUNDAY • MAY 15 Facilitator: P
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60 SUNDAY • MAY 15 P1243 P1244 P1
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62 SUNDAY • MAY 15 P1295 P1296 P1
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64 SUNDAY • MAY 15 P1358 P1359 P1
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66 SUNDAY • MAY 15 P91 Facilitato
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68 SUNDAY • MAY 15 P616 P617 P618
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70 SUNDAY • MAY 15 P914 P915 P916
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72 SUNDAY • MAY 15 P556 P557 P558
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74 SUNDAY • MAY 15 Facilitators:
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76 SUNDAY • MAY 15 P997 P998 P999
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78 SUNDAY • MAY 15 P256 P257 P258
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80 SUNDAY • MAY 15 A61 THEMATIC P
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82 SUNDAY • MAY 15 P824 Facilitat
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84 SUNDAY • MAY 15 P1055 P1056 P1
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86 SUNDAY • MAY 15 P1101 P1102 P1
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88 SUNDAY • MAY 15 P1423 P1424 P1
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90 SUNDAY • MAY 15 P1474 P1475 P1
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92 SUNDAY • MAY 15 P377 P378 P379
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94 SUNDAY • MAY 15 P281 P282 P283
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96 SUNDAY • MAY 15 P450 P451 A74
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98 SUNDAY • MAY 15 P1562 P1563 P1
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100 SUNDAY • MAY 15 A80-A THEMATI
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102 SUNDAY • MAY 15 Facilitator:
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104 SUNDAY • MAY 15 11:00 a.m.-12
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106 SUNDAY • MAY 15 L1 U.S. FOOD
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108 SUNDAY • MAY 15 12:15 Post-Pr
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110 SUNDAY • MAY 15 MP406 MP407 M
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112 SUNDAY • MAY 15 clinician and
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114 SUNDAY • MAY 15 A86 BASIC •
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116 SUNDAY • MAY 15 Chairing: M.J
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118 SUNDAY • MAY 15 3:30 High Pre
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120 SUNDAY • MAY 15 102 Toll-Like
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122 SUNDAY • MAY 15 A103 POSTER D
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124 SUNDAY • MAY 15 719 Lactate R
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126 SUNDAY • MAY 15 1014 Determin
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128 SUNDAY • MAY 15 611 Plasma Mi
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130 SUNDAY • MAY 15 412 Daytime S
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132 SUNDAY • MAY 15 6:30 p.m. - 8
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134 MONDAY • MAY 16 SS111 SS112 S
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136 MONDAY • MAY 16 Target Audien
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138 MONDAY • MAY 16 9:40 Empoweri
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140 MONDAY • MAY 16 9:28 Endotoxi
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142 MONDAY • MAY 16 10:15 Adaptiv
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144 MONDAY • MAY 16 Oral Presenta
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146 MONDAY • MAY 16 624 Neonatal
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148 MONDAY • MAY 16 118 Compariso
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150 MONDAY • MAY 16 912 Should Pa
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152 MONDAY • MAY 16 1015 Resverat
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154 MONDAY • MAY 16 718 Health Re
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156 MONDAY • MAY 16 P152 Facilita
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158 MONDAY • MAY 16 B35 THEMATIC
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160 MONDAY • MAY 16 P252 P253 P25
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162 MONDAY • MAY 16 P406 P407 P40
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164 MONDAY • MAY 16 P320 Bilatera
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166 MONDAY • MAY 16 B40 THEMATIC
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168 MONDAY • MAY 16 P528 P529 Fac
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170 MONDAY • MAY 16 Facilitator:
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172 MONDAY • MAY 16 B44 THEMATIC
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174 MONDAY • MAY 16 P484 P485 P48
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176 MONDAY • MAY 16 P1161 P1162 P
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178 MONDAY • MAY 16 B48 THEMATIC
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180 MONDAY • MAY 16 P1238 P1239 P
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182 MONDAY • MAY 16 P1297 P1298 P
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184 MONDAY • MAY 16 Facilitator:
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186 MONDAY • MAY 16 P15 P16 P17 P
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188 MONDAY • MAY 16 Facilitator:
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190 MONDAY • MAY 16 P114 P115 P11
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192 MONDAY • MAY 16 P1408 Enhance
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194 MONDAY • MAY 16 P1455 P1456 P
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196 MONDAY • MAY 16 P1487 P1488 P
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198 MONDAY • MAY 16 P1514 P1515 P
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200 MONDAY • MAY 16 Facilitator:
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202 MONDAY • MAY 16 P559 P560 P56
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204 MONDAY • MAY 16 WS3 CLINICAL
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206 MONDAY • MAY 16 Satellite ear
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208 MONDAY • MAY 16 Objectives At
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210 MONDAY • MAY 16 encourage tra
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212 MONDAY • MAY 16 B82 BEHAVIORA
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214 MONDAY • MAY 16 B86 BASIC •
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216 MONDAY • MAY 16 and a number
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218 MONDAY • MAY 16 2:30 Mortalit
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220 MONDAY • MAY 16 3:00 Simultan
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222 MONDAY • MAY 16 525 Clinical
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224 MONDAY • MAY 16 320 Sensitivi
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226 MONDAY • MAY 16 113 COPD Subt
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228 MONDAY • MAY 16 1004 Health C
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230 MONDAY • MAY 16 609 Skeletal
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232 MONDAY • MAY 16 5:00 p.m. - 7
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234 TUESDAY • MAY 17 Chairing: D.
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236 TUESDAY • MAY 17 CLINICAL YEA
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238 TUESDAY • MAY 17 This session
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240 TUESDAY • MAY 17 bronchiectas
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242 TUESDAY • MAY 17 Target Audie
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344 WEDNESDAY • MAY 18 10:15 Plas
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346 WEDNESDAY • MAY 18 419 A Nove
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348 WEDNESDAY • MAY 18 216 Simpli
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350 WEDNESDAY • MAY 18 815 Multip
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352 WEDNESDAY • MAY 18 D28 POSTER
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354 WEDNESDAY • MAY 18 720 Repeat
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356 WEDNESDAY • MAY 18 P389 Facil
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358 WEDNESDAY • MAY 18 P439 P440
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360 WEDNESDAY • MAY 18 P10 P11 P1
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362 WEDNESDAY • MAY 18 P52 P53 Fa
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364 WEDNESDAY • MAY 18 P95 P96 P9
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366 WEDNESDAY • MAY 18 P698 P699
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368 WEDNESDAY • MAY 18 D42 THEMAT
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370 WEDNESDAY • MAY 18 P748 Funge
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372 WEDNESDAY • MAY 18 P353 P354
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374 WEDNESDAY • MAY 18 P172 P173
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376 WEDNESDAY • MAY 18 P808 Facil
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378 WEDNESDAY • MAY 18 P526 P527
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380 WEDNESDAY • MAY 18 P579 P580
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382 WEDNESDAY • MAY 18 P944 P945
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384 WEDNESDAY • MAY 18 P991 P992
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386 WEDNESDAY • MAY 18 P1036 P103
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388 WEDNESDAY • MAY 18 P1062 P106
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390 WEDNESDAY • MAY 18 11:45 Intr
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392 WEDNESDAY • MAY 18 12:15 Upda
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394 WEDNESDAY • MAY 18 This sessi
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396 WEDNESDAY • MAY 18 1:30 The B
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398 WEDNESDAY • MAY 18 D88 BEHAVI
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400 WEDNESDAY • MAY 18 3:00 Accel
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402 WEDNESDAY • MAY 18 D96 MINI S
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404 WEDNESDAY • MAY 18 604 CARMA3
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406 WEDNESDAY • MAY 18 702 Potent
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408 WEDNESDAY • MAY 18 803 ICU Ac
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410 WEDNESDAY • MAY 18 Chairing:
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412 WEDNESDAY • MAY 18 404 Interm
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Where today’s science meets tomor