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Pediatric Informatics: Computer Applications in Child Health (Health ...

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376 M. Apkon<br />

medication vial and compare it with the medication order. Throughout the task,<br />

attention was required to ensure that the standard operat<strong>in</strong>g procedure was followed<br />

correctly.<br />

The likelihood of error or failure would be reduced if tasks could be elim<strong>in</strong>ated.<br />

One could consider the overall task of replac<strong>in</strong>g the medication cassette. Were the<br />

cassettes to hold a larger volume, the task of replacement would not be required as<br />

frequently which would reduce the likelihood of harm over the course of therapy.<br />

One could also consider the component tasks of the replacement process. If the<br />

task of choos<strong>in</strong>g, whether to wait for the patient’s medication drawer to be refilled<br />

or to override the dispens<strong>in</strong>g mach<strong>in</strong>e and choose an alternative mechanism for<br />

dispens<strong>in</strong>g, were elim<strong>in</strong>ated, there would not be an opportunity for error.<br />

The likelihood of error would also be reduced if certa<strong>in</strong> functions could be<br />

replaced. For example, the function of memory could be replaced by <strong>in</strong>formation<br />

systems that make the correct dose retrievable at the dispens<strong>in</strong>g mach<strong>in</strong>e.<br />

Alternatively, functions could be facilitated so that they would be less error prone.<br />

Electronic calculators are examples of mechanisms to facilitate the action of<br />

perform<strong>in</strong>g mathematical operations to reduce the likelihood of mistakes.<br />

Even when errors occur, harm can be prevented by detect<strong>in</strong>g abnormalities<br />

early. In the example of the patient receiv<strong>in</strong>g a narcotic <strong>in</strong>fusion, monitor<strong>in</strong>g blood<br />

oxygenation or exhaled carbon dioxide could detect respiratory depression as a<br />

consequence of an overdose before any permanent harm occurs. When abnormalities<br />

are detected and even when they are not, there may be opportunities to mitigate<br />

harm or rescue. In cont<strong>in</strong>u<strong>in</strong>g the overdose scenario, respiratory depression could<br />

be reversed us<strong>in</strong>g pharmacologic antidotes or a patient may be resuscitated with<br />

mechanical ventilation and supported until the medications are metabolized.<br />

Innovative solutions that reduce error may arise from any number of creative<br />

processes. Seek<strong>in</strong>g solutions that elim<strong>in</strong>ate tasks, replace or facilitate function,<br />

detect abnormalities, or enable rescue provide a useful framework and helps<br />

generate a broad range of countermeasures for consideration.<br />

29.6 High Reliability and <strong>Informatics</strong><br />

29.6.1 Information Technology<br />

and Error-Proof<strong>in</strong>g Strategies<br />

Information technology can be <strong>in</strong>corporated <strong>in</strong>to each of the error-proof<strong>in</strong>g strategies<br />

described above. For example, computerized physician order entry (CPOE)<br />

solutions could be used to elim<strong>in</strong>ate tasks, replace or facilitate actions, improve<br />

detection of abnormalities and help ensure rescue.<br />

Consider the order<strong>in</strong>g of methotrexate, a potent cancer chemotherapeutic agent<br />

that is adm<strong>in</strong>istered <strong>in</strong> doses based on body surface area which is calculated based<br />

on a patient’s height and weight. It is common to monitor serum methotrexate

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