Part-I - Controller General of Patents Designs and Trademarks

(12) PATENT APPLICATION PUBLICATION (21) Application No.3054/MUM/2010 A
(19) INDIA
(22) Date of filing of Application :03/11/2010 (43) Publication Date : 21/06/2013
(54) Title of the invention : A NEW PROCESS FOR PREPARING OPTICALLY PURE MILNACIPRAN AND ITS
PHARMACEUTICALLY ACCEPTABLE SALTS
(51) International classification
(31) Priority Document No :NA
(32) Priority Date :NA
(33) Name of priority country :NA
(86) International Application No
:NA
Filing Date
:NA
(87) International Publication No :N/A
(61) Patent of Addition to Application Number :NA
Filing Date
:NA
(62) Divisional to Application Number :NA
Filing Date
:NA
:C07C221/00;
C07C225/00
(71)Name of Applicant :
1)ARCH PHARMALABS LIMITED
Address of Applicant :H WING, 4TH FLOOR, TEX
CENTRE, OFF SAKI VIHAR ROAD, CHANDIVALI,
ANDHERI (EAST), MUMBAI-400 072, INDIA Maharashtra
India
(72)Name of Inventor :
1)PAI, GANESH GURPUR
2)RANBHAN, KAMLESH JAYANTILAL
3)JAGTAP, VIKRAM SARJERAO
4)PATIL, DAYAGHAN GANGADHAR
5)ZUNJARRAO, YUVRAJ KASHINATH
6)MANDAL, ARUN KANTI
(57) Abstract :
The present invention relates to an improved and commercially viable process for the resolution of racemic cis milnacipran of
formula I and its pharmaceutically acceptable salts of formula II. The present invention comprises using racemic cis milnacipran
or its pharmaceutically acceptable salts as starting material, a low cost and commercially available resolving agent of formula III
and industrially safe and economically low cost material such as water as a solvent. The said process results into optical isomers
of racemic cis milnacipran having excellent optical purity without involving multiple crystallization steps. The present invention
also comprises the concept of green chemistry as the invention works well with water as a solvent thereby minimizing the use of
any other solvent.
No. of Pages : 45 No. of Claims : 8
The Patent Office Journal 21/06/2013 13546