Part-I - Controller General of Patents Designs and Trademarks

(12) PATENT APPLICATION PUBLICATION (21) Application No.1920/CHENP/2012 A
(19) INDIA
(22) Date of filing of Application :01/03/2012 (43) Publication Date : 21/06/2013
(54 Title of the invention : FKBP52-TAU INTERACTION A A NOVEL THERAPEUTICAL TARGET FOR TREATING
THE NEUROLOGICAL DISORDERS INVOLVING TAU DYSFUNCTION•
(51) International classification :G01N 33/68
(31) Priority Document No :09305893.1
( 2) Pr ority ate :24/09/2009
(33) Name of priority country :EPO
(86) International Application No
Filing Date
(87) International Publication No : NA
(61) Patent of Addition to Application
:NA
Number
:NA
Filing Date
(62) Divisional to Application Number
Filing Date
:PCT/EP2010/064115
:24/09/2010
:NA
:NA
(71)Name of Applicant :
1)INSERM (INSTITUT NATIONAL DE LA SANT‰ ET
DE LA RECHERCHE M‰DICALE)
Address of Applicant :101 rue de Tolbiac F-75013 Paris
France
(72)Name of Inventor :
1)BAULIEU Etienne
2)CHAMBRAUD Batrice
(57) Abstract :
The invention relates generally to neuroprotection and repair in neurological disorders involving Tau dysfunction (including
Alzheimers disease). The invention describes AND INCLUDES a direct interaction between proteins FKBP52 and Tau. More
particularly the invention relates to a method for screening a drug for the prevention and treatment of neurological disorders
involving Tau dysfunction comprising the following steps: a) determining the ability of a candidate compound to modulate the
interaction between a Tau polypeptide and a FKBP52 polypeptide and b) selecting positively the candidate compound that
modulates said interaction. The present invention finally relates to diagnostic prognostic and monitoring assays of neurological
disorders involving Tau dysfunction.
No. of Pages : 59 No. of Claims : 10
The Patent Office Journal 21/06/2013 13957