Part-I - Controller General of Patents Designs and Trademarks

(12) PATENT APPLICATION PUBLICATION (21) Application No.3094/MUM/2010 A
(19) INDIA
(22) Date of filing of Application :11/11/2010 (43) Publication Date : 21/06/2013
(54) Title of the invention : A METHOD FOR PREPARING RAMIPRIL
(51) International classification
(31) Priority Document No :NA
(32) Priority Date :NA
(33) Name of priority country :NA
(86) International Application No
:NA
Filing Date
:NA
(87) International Publication No : NA
(61) Patent of Addition to Application Number :NA
Filing Date
:NA
(62) Divisional to Application Number :NA
Filing Date
:NA
:C07C231/18;
C07D209/52;
C07D233/47
(71)Name of Applicant :
1)AARTI HEALTHCARE LIMITED
Address of Applicant :AARTI HEALTHCARE LIMITED,
D-53/D-60, MIDC, PHASE II, KALYAN SHILL ROAD,
DOMBIVALI (E), DISTRICT THANE, MUMBAI - 421 204,
MAHARASHTRA, INDIA.
(72)Name of Inventor :
1)MR. PARIMAL HASMUKHLAL DESAI
2)MR. NARENDRA JAGANNATH SALVI
3)DR. BHARATKUMAR SURENDRA PATRAVALE
(57) Abstract :
Enantio-specfiic synthesis of optically pure (2S)-acetylamino-3 -(2-oxo-cyclopentyl)-propionic acid (I) comprising converting
enantiomeric mixture of (1-4C alkyl)-2-acetylamino-3-(2-oxocyc]opentyl) propionoate (II) (+ and -) under the influence of an
Alkaline serine endopeptidase is disclosed. The invention farther describes use of optically pure (2S)-acetylamino-3-(2-
oxocycIopentyl)-propionic acid (I) formed by the process of present invention, in the preparation of Ramipril.
No. of Pages : 26 No. of Claims : 20
The Patent Office Journal 21/06/2013 13564