Part-I - Controller General of Patents Designs and Trademarks

(12) PATENT APPLICATION PUBLICATION (21) Application No.1040/CHENP/2012 A
(19) INDIA
(22) Date of filing of Application :01/02/2012 (43) Publication Date : 21/06/2013
(54) Title of the invention : PERFLUORO COMPOUNDS FOR USE IN IMAGING
(51) International classification :A61K49/10
(31) Priority Document No :09166955.6
(32) Priority Date :31/07/2009
(33) Name of priority country :EPO
(86) International Application No
Filing Date
(87) International Publication No : NA
(61) Patent of Addition to Application
:NA
Number
:NA
Filing Date
(62) Divisional to Application Number
Filing Date
:PCT/IB2010/053321
:21/07/2010
:NA
:NA
(71)Name of Applicant :
1)KONINKLIJKE PHILIPS ELECTRONICS N.V.
Address of Applicant :GROENEWOUDSEWEG 1
EINDHOVEN 5621 BA NETHERLANDS
(72)Name of Inventor :
1)YILDIRIM Muhammed
2)GRUELL Holger
3)LAMERICHS Rudolf Mathias Johannes Nicolaas
(57) Abstract :
Described is the use of perfluoro-t-butyl cyclohexane in a contrast agent for molecular imaging notably 19F MRI. Particularly
the perfluoro-t-butyl cyclohexane is present in the form of an aqueous emulsion of nanoparticles comprising the perfluoro
compound as a core and an emulsifying agent such as a phospholipid as a shell. The shell can be functionalized with other
moieties that play a role in imaging notably ligands for targeted binding and/or contrast agents or labels with a view to other
imaging modalities. The latter particularly refers to 1H MRI contrast agents as well as radiolabels for SPECT.
No. of Pages : 13 No. of Claims : 13
The Patent Office Journal 21/06/2013 13705