Part-I - Controller General of Patents Designs and Trademarks

(12) PATENT APPLICATION PUBLICATION (21) Application No.1988/MUM/2013 A
(19) INDIA
(22) Date of filing of Application :11/06/2013 (43) Publication Date : 21/06/2013
(54) Title of the invention : A HIGH YIELD, HIGH PURITY ECO-FRIENDLY INDUSTRIAL PROCESS FOR THE
PREPARATION OF BUPRENORPHINE AND ITS INTERMEDIATES.
(51) International classification
(31) Priority Document No :NA
(32) Priority Date :NA
(33) Name of priority country :NA
(86) International Application No
:NA
Filing Date
:NA
(87) International Publication No : NA
(61) Patent of Addition to Application Number :NA
Filing Date
:NA
(62) Divisional to Application Number :NA
Filing Date
:NA
:C07D489/12;
C07D489/00
(71)Name of Applicant :
1)RUSAN PHARMA LIMITED
Address of Applicant :58-D, GOVERNMENT
INDUSTRIAL ESTATE, CHARKOP, KANDIVALI (WEST),
MUMBAI - 400 067, MAHARASHTRA, INDIA.
(72)Name of Inventor :
1)SAXENA, NAVIN SATYAPAL
2)SAXENA, KUNAL
3)SATA, KAUSHIK BABUBHAI
(57) Abstract :
The present invention discloses an efficient industrial process for the preparation of 21-cyclopropyl-7a-(2-hydroxy-3,3-dimethyl-
2-butyl)-6,14-endo-ethano-6,7,8,14-tetrahydro-oripavine, i.e Buprenorphine of Formula-I in high yield and purity, with enhanced
safety and eco-friendly norms. The invention further relates to an improved process for preparation of intermediates thereof in
high yield and purity.
No. of Pages : 30 No. of Claims : 11
The Patent Office Journal 21/06/2013 13443