Part-I - Controller General of Patents Designs and Trademarks

(12) PATENT APPLICATION PUBLICATION (21) Application No.3089/MUM/2010 A
(19) INDIA
(22) Date of filing of Application :10/11/2010 (43) Publication Date : 21/06/2013
(54) Title of the invention : PROCESS FOR THE PREPARATION OF 2-N-BUTYL-3-[4-(3-DI-N-BUTYLAMINO-PROPXY)
BENZOYL]-5-NITRO BENZOFURAN
(51) International classification :c07d307/87
(31) Priority Document No :NA
(32) Priority Date :NA
(33) Name of priority country :NA
(86) International Application No
:NA
Filing Date
:NA
(87) International Publication No : NA
(61) Patent of Addition to Application Number :NA
Filing Date
:NA
(62) Divisional to Application Number
:NA
Filing Date
:NA
(71)Name of Applicant :
1)WOCKHARDT LIMITED
Address of Applicant :D-4 MIDC Industrial area
Chikalthana Aurangabad - 431210 M.S. India India
(72)Name of Inventor :
1)Laxman Narkhede
2)Nitin Gupta
3)Bhatraju Srinivasa Rao
4)Keshav Deo
(57) Abstract :
The present invention provides a process for the preparation of 2-n-butyl-3-[4-(3-di-n-butylamino-propxy) benzoyl]-5-nitro
benzofuran, an intermediate for the preparation of Dronedarone HCl. The process comprises reacting 2-n-butyl-3-(4-
hydroxybenzoyl)-5-nitrobenzofuran and 1-chloro-3-di-n-butylaminopropane in the presence of a base and a solvent excepting the
ketonic solvent, methyl ethyl ketone or optionally in presence a phase transfer catalyst and water or a mixture of water to produce
2-n-butyl-3-[4-(3-di-n-butylamino-propxy) benzoyl]-5-nitro benzofuran. Reaction goes to completion in less than 12 hours with
higher yield and purity.
No. of Pages : 9 No. of Claims : 10
The Patent Office Journal 21/06/2013 13561