Part-I - Controller General of Patents Designs and Trademarks

(12) PATENT APPLICATION PUBLICATION (21) Application No.3674/DEL/2011 A
(19) INDIA
(22) Date of filing of Application :16/12/2011 (43) Publication Date : 21/06/2013
(54) Title of the invention : METHOD FOR COMPUTING PHARMACOKINETIC PARAMETERS IN MRI
(51) International classification :B23B
(31) Priority Document No :NA
(32) Priority Date :NA
(33) Name of priority country :NA
(86) International Application No
:NA
Filing Date
:NA
(87) International Publication No :NA
(61) Patent of Addition to Application Number :NA
Filing Date
:NA
(62) Divisional to Application Number
:NA
Filing Date
:NA
(71)Name of Applicant :
1)RAJIV GANDHI CANCER INSTITUTE &
RESEARCH CENTRE
Address of Applicant :SECTOR - V, ROHINI, DELHI -
110085 Delhi India
(72)Name of Inventor :
1)JENA, AMARNATH
2)MEHTA, SHASHI BHUSHAN
3)TANEJA, SANGEETA
4)SARKAR, URMI
(57) Abstract :
The present invention relates to a method of dynamic contrast magnetic resonance imaging aimed to improve characterization of
tissue image by improving accuracy of computed pharmacokinetic parameters such as Ktrans (transfer constant across capillary
membrane; a pharmacokinetic parameter of tissue perfusion) using T1W Fast DCE-MRI technique to distinguish between
malignant, benign and normal tissues. A phantom and a contrast agent are used in the proposed MRI system for computing
accurate T1 value of a tissue after the contrast is injected based on an intrinsic T10 value the tissue, wherein the intrinsic T10
value is adjusted and/or normalized to improve accuracy of the T1 value computed, which in turn is used for computation of
pharmacokinetic parameters at least one of Ktrans.
No. of Pages : 25 No. of Claims : 12
The Patent Office Journal 21/06/2013 13470