Part-I - Controller General of Patents Designs and Trademarks

(12) PATENT APPLICATION PUBLICATION (21) Application No.1780/CHE/2011 A
(19) INDIA
(22) Date of filing of Application :26/05/2011 (43) Publication Date : 21/06/2013
(54) Title of the invention : A PROCESS FOR PREPARATION OF MEROPENEM
(51) International classification :C07C
(31) Priority Document No :NA
(32) Priority Date :NA
(33) Name of priority country :NA
(86) International Application No
:NA
Filing Date
:NA
(87) International Publication No : NA
(61) Patent of Addition to Application Number :NA
Filing Date
:NA
(62) Divisional to Application Number
:NA
Filing Date
:NA
(71)Name of Applicant :
1)SEQUENT SCIENTIFIC LIMITED
Address of Applicant :STAR - II, OPP. TO INDIAN
INSTITUTE OF MANAGEMENT BANNERGHATTA ROAD,
BANGALORE - 56 076 Karnataka India
(72)Name of Inventor :
1)GNANPRAKASAM, ANDREW
2)GANAPATHY, VEERAMANI
3)SYED IBRAHIM, SHAHUL HAMEED
4)KARTHIKEYAN, MURUGESAN
5)SIVASAMY, THANGAVEL
6)SEKAR, JEYARAJ
7)ARULMOLI, THANGAVEL
(57) Abstract :
The present invention relates to a novel, cost-effective process for the preparation of Sterile Meropenem Trihydrate, which is
prepared by a) condensation of l-Azabicyclo[3.2.0]hepta-2-ene-2-carboxylic acid, 3-[(diphenoxyphosphinyl)oxy]-6-(lhydroxyethyl)-4-methyl-7-oxo-(4-nitrobenzyl)
methyl ester,[4R-[4a,5b,6b(R)]] with (2S,4S)-2-(Dimethylaminocarbonyl)-4-
mercapto-l-(p-nitrobenzyloxycarbonyl)-l-pyrrolidine to obtain diprotected Meropenem; b) deprotection and hydrogenation of
diprotected Meropenem to obtain non-sterile Meropenem Trihydrate; c) conversion of NS Meropenem Trihydrate into Sterile
Meropenem Trihydrate by using water , methanolic ammonia solution and purging carbon dioxide gas.
No. of Pages : 14 No. of Claims : 10
The Patent Office Journal 21/06/2013 13922