Part-I - Controller General of Patents Designs and Trademarks

(12) PATENT APPLICATION PUBLICATION (21) Application No.1593/CHE/2011 A
(19) INDIA
(22) Date of filing of Application :09/05/2011 (43) Publication Date : 21/06/2013
(54) Title of the invention : A PROCESS FOR PREPARATION OF DIMINAZENE DIACETURATE
(51) International classification :C07D
(31) Priority Document No :NA
(32) Priority Date :NA
(33) Name of priority country :NA
(86) International Application No
:NA
Filing Date
:NA
(87) International Publication No : NA
(61) Patent of Addition to Application Number :NA
Filing Date
:NA
(62) Divisional to Application Number
:NA
Filing Date
:NA
(71)Name of Applicant :
1)SEQUENT SCIENTIFIC LIMITED
Address of Applicant :STAR-II, OPPOSITE TO INDIAN
INSTITUTE OF MANAGEMENT, BILEKAHALLI,
BANNERGHATTA ROAD, BANGALORE - 560 076
Karnataka India
(72)Name of Inventor :
1)VERMA, SUDHAKAR
2)ARULMOLI, THANGAVEL
(57) Abstract :
The present invention discloses a novel, cost-effective process for preparation of a diazoamino benzene compound. Specifically, it
relates to the process for the preparation of diminazene diaceturate. The process comprises a) converting p-nitro benzoic acid of
formula VII into p-nitro benzamide of formula VI; b) converting p-nitro benzamide of formula VI into p-nitro benzonitrile of
formula V ; c) converting p-nitro benzonitrile of formula V into p-nitro benzamidoxime of formula IV ; d) reducing the p-nitro
benzamidoxime of formula IV to obtain p-amino benzamidine dihydrochloride of formula III ; e) diazotising p-amino
benzamidine dihydrochloride of formula III, followed by coupling of diazonium salt of p-amino benzamidine dihydrochloride
with p-amino benzamidine dihydrochloride to obtain diminazene of formula II; f) reacting diminazene of formula II obtained in
step e) with aceturic acid to form diminazene diaceturate of formula I.
No. of Pages : 11 No. of Claims : 10
The Patent Office Journal 21/06/2013 13985